Gene: VWA3B

200403
SCAR22
von Willebrand factor A domain containing 3B
protein-coding
2q11.2
Ensembl:ENSG00000168658 MIM:614884 Vega:OTTHUMG00000153104 UniprotKB:Q502W6
NG_054753.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.464e-1 (AD)  3.369e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4608580chr2:98244594 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08026735chr2:98703888VWA3B2.360e-10Maternal smoking in pregnancy27040690
cg08026735chr2:98703888VWA3B9.110e-10Maternal smoking in pregnancy27040690
cg08026735chr2:98703888VWA3B4.320e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GDPD20.675
PLEKHA70.653
C10orf1050.652
ENTPD20.651
LCTL0.649
IGDCC40.635
SLC16A90.63
PLCD10.623
HOGA10.619
TBL1X0.619

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BDNF-0.372
GABRG3-0.367
FAM160A1-0.363
GPR68-0.361
OSBPL10-0.36
PCSK1-0.359
KCNK9-0.358
MCHR1-0.355
DUSP27-0.355
TRABD2A-0.347

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of VWA3B gene27153756
D001151ArsenicArsenic affects the methylation of VWA3B gene25304211
C547126AZM551248AZM551248 results in decreased expression of VWA3B mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of VWA3B mRNA28159858
C006780bisphenol Abisphenol A affects the expression of VWA3B mRNA25181051
D003300CopperCopper deficiency results in increased expression of VWA3B mRNA26033743
D019327Copper SulfateCopper Sulfate affects the expression of VWA3B mRNA19549813
D003471CuprizoneCuprizone results in increased expression of VWA3B mRNA26577399
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of VWA3B mRNA"25908611
D004041Dietary FatsDietary Fats results in decreased expression of VWA3B mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of VWA3B mRNA26033743
C008261lead acetatelead acetate affects the expression of VWA3B mRNA21864555
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of VWA3B mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of VWA3B mRNA"25620056
C006253pirinixic acidpirinixic acid results in increased expression of VWA3B mRNA23811191
D011441PropylthiouracilPropylthiouracil results in increased expression of VWA3B mRNA24780913
D053260SootSoot results in decreased expression of VWA3B mRNA26551751
C009495titanium dioxidetitanium dioxide affects the expression of VWA3B mRNA23557971
C088658zoledronic acidzoledronic acid results in increased expression of VWA3B mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal