Gene: ZBTB7C

201501
APM-1|APM1|ZBTB36|ZNF857C
zinc finger and BTB domain containing 7C
protein-coding
18q21.1
Ensembl:ENSG00000184828 MIM:616591 Vega:OTTHUMG00000180322 UniprotKB:A1YPR0
NC_000018.10
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.689e-1 (AD)  9.549e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9957779chr18:48291377 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6507820chr18:48167910 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4939747chr18:48162470 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HPCAL10.797
HS6ST10.776
TMEM1080.758
PRDM110.754
ASB20.753
MAN1C10.753
CDC60.739
MBOAT70.738
RND10.735
KCNK120.729

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA3-0.457
SLCO1A2-0.45
ZFP57-0.426
C5orf64-0.422
UACA-0.405
SEPT10-0.387
OR4F5-0.383
P2RX1-0.382
OPALIN-0.381
VRK2-0.381

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ZBTB7C mRNA19933214
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of ZBTB7C mRNA19191707
C006780bisphenol Abisphenol A results in increased expression of ZBTB7C mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of ZBTB7C mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ZBTB7C gene28505145
D003471CuprizoneCuprizone results in increased expression of ZBTB7C mRNA26577399
D003907DexamethasoneDexamethasone results in decreased expression of ZBTB7C mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ZBTB7C mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ZBTB7C mRNA22023808
D004041Dietary FatsDietary Fats results in increased expression of ZBTB7C mRNA25016146
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ZBTB7C mRNA18936297
C039281furanfuran results in increased expression of ZBTB7C mRNA27387713
D007854LeadLead affects the expression of ZBTB7C mRNA28903495
C006253pirinixic acidpirinixic acid results in decreased expression of ZBTB7C mRNA23811191
D011374ProgesteroneProgesterone results in decreased expression of ZBTB7C mRNA23012394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZBTB7C mRNA28922406
C009495titanium dioxidetitanium dioxide results in decreased expression of ZBTB7C mRNA23409001
D014635Valproic AcidValproic Acid affects the expression of ZBTB7C mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of ZBTB7C gene29154799
D014635Valproic AcidValproic Acid affects the expression of ZBTB7C mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003674molecular_function-ND-  
GO:0003676nucleic acid binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008285negative regulation of cell proliferation-IDA9427755  
GO:0045600positive regulation of fat cell differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:1903025regulation of RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal