Gene: TSNARE1

203062
-
t-SNARE domain containing 1
protein-coding
8q24.3
Ensembl:ENSG00000171045 Vega:OTTHUMG00000164867 UniprotKB:Q96NA8
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.249e-1 (AD)  4.847e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6583607chr8:142243038 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PKD10.889
MAP3K120.889
DPH10.886
IFT1720.882
CHRD0.881
TUBGCP60.878
KIAA0895L0.877
GGT70.872
ABCC100.871
MAPKBP10.87

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.474
OR4F29-0.449
ZNF114-0.442
PHEX-0.429
CLEC2B-0.424
FAM89A-0.42
MTRNR2L9-0.419
KIAA0040-0.411
MTRNR2L6-0.41
EGFLAM-0.407

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of TSNARE1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TSNARE1 mRNA22100608
D001151ArsenicArsenic affects the methylation of TSNARE1 gene25304211
C547126AZM551248AZM551248 results in decreased expression of TSNARE1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TSNARE1 mRNA26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TSNARE1 mRNA"26238291
D003976DiazinonDiazinon results in increased methylation of TSNARE1 gene22964155
D004121Dimethyl SulfoxideDimethyl Sulfoxide affects the expression of TSNARE1 mRNA24834073
C544151jinfukangjinfukang results in increased expression of TSNARE1 mRNA27392435
D014635Valproic AcidValproic Acid results in increased methylation of TSNARE1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0005484SNAP receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006886intracellular protein transport-IBA21873635  
GO:0006906vesicle fusion-IBA21873635  
GO:0048278vesicle docking-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0012505endomembrane system-IBA21873635  
GO:0016021integral component of membrane-IBA21873635  
GO:0031201SNARE complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal