Gene: ALDH2

217
ALDH-E2|ALDHI|ALDM
aldehyde dehydrogenase 2 family member
protein-coding
12q24.12
Ensembl:ENSG00000111275 MIM:100650 Vega:OTTHUMG00000169603 UniprotKB:P05091
NG_012250.1
PubMed|SNP Mapped
1   ANCO-SNPs
CD|OD|ND|AD
386   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.432e-1 (AD)  6.347e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs671chr12:111803962 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLUD10.942
SRI0.912
PRDX60.911
MT30.909
FXYD10.907
HADHB0.905
NDRG20.905
CST30.897
CYB5R30.894
DCXR0.893

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.75
OR4F29-0.743
COL19A1-0.27
PROKR2-0.268
IL1RAPL2-0.262
IL12RB2-0.26
TYRP1-0.258
GABRG3-0.251
ZNF860-0.246
CLMP-0.245

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0143181-aminocyclopropanol[1-aminocyclopropanol analog results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin18272654
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of ALDH2 mRNA20566314
C0170621-benzylimidazole1-benzylimidazole inhibits the reaction [NADP promotes the reaction [Thiocarbamates analog results in decreased activity of ALDH2 protein]]9585485
C0166141-nitronaphthalene1-nitronaphthalene metabolite binds to ALDH2 protein16453347
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALDH2 mRNA"19114083
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of ALDH2 protein"27604104
C0269782,3-butylene glycol"ALDH2 protein results in increased metabolism of 2,3-butylene glycol"10064379
C0573492,4-decadienal"ALDH2 protein affects the oxidation of 2,4-decadienal"12604195
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ALDH2 mRNA"21346803
C1127842,5-dihydroxybenzaldehyde"ALDH2 protein results in increased metabolism of 2,5-dihydroxybenzaldehyde"11744614
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol inhibits the reaction [ALDH2 protein results in increased metabolism of Formaldehyde]"19822198
C0212962-ethoxyethanolALDH2 protein promotes the reaction 2-ethoxyethanol17878629
C0498262-methoxyacetaldehydeALDH2 protein results in increased oxidation of 2-methoxyacetaldehyde18940187
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ALDH2 mRNA"19692669
C0074303,4-dihydroxyphenylacetaldehyde"3,4-dihydroxyphenylacetaldehyde binds to ALDH2 protein"21238438
C0179063-dinitrobenzene3-dinitrobenzene binds to ALDH2 protein11896682
C0179063-dinitrobenzene3-dinitrobenzene results in increased metabolism of ALDH2 protein21402099
C0112753-hydroxybenzaldehydeALDH2 protein results in increased metabolism of 3-hydroxybenzaldehyde11744614
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ALDH2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
C0555064-(diethylamino)benzaldehyde4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH2 protein25512087
C0185234-dimethylaminocinnamaldehyde4-dimethylaminocinnamaldehyde binds to ALDH2 protein10609638
C0185234-dimethylaminocinnamaldehydeacetophenone inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]10609638
C0185234-dimethylaminocinnamaldehydebenzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]10609638
C0185234-dimethylaminocinnamaldehydephenacyl bromide inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]10609638
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal binds to and results in decreased activity of ALDH2 protein22339434
C0275764-hydroxy-2-nonenalALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]25263579
C0275764-hydroxy-2-nonenalALDH2 protein results in increased oxidation of 4-hydroxy-2-nonenal22339434
C0275764-hydroxy-2-nonenal[APC protein mutant form results in increased expression of ALDH2 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal21967605
C0086424-nitrophenyl acetateALDH2 protein results in increased hydrolysis of 4-nitrophenyl acetate21349255
C0086424-nitrophenyl acetatedaidzin inhibits the reaction [ALDH2 protein results in increased hydrolysis of 4-nitrophenyl acetate]21349255
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
D000079AcetaldehydeALDH2 gene polymorphism affects the oxidation of Acetaldehyde19393179
D000079AcetaldehydeALDH2 gene polymorphism affects the susceptibility to Acetaldehyde15840430
D000079AcetaldehydeALDH2 gene polymorphism results in decreased metabolism of Acetaldehyde8512495
D000079AcetaldehydeALDH2 protein polymorphism affects the metabolism of Acetaldehyde11744614
D000079AcetaldehydeALDH2 protein polymorphism results in decreased metabolism of Acetaldehyde15380331
D000079AcetaldehydeALDH2 protein results in decreased susceptibility to Acetaldehyde14722101
D000079AcetaldehydeALDH2 protein results in increased chemical synthesis of Acetaldehyde10940605
D000079AcetaldehydeALDH2 protein results in increased metabolism of Acetaldehyde10780266|1082610
D000079AcetaldehydeALDH2 protein results in increased oxidation of Acetaldehyde18940187|1939317
D000079AcetaldehydeALDH2 protein results in increased susceptibility to Acetaldehyde15840430
D000079AcetaldehydeALDH2 protein affects the susceptibility to Acetaldehyde18303182
D000079AcetaldehydeALDH2 protein mutant form results in decreased metabolism of Acetaldehyde16340452
D000079AcetaldehydeALDH2 protein results in increased metabolism of Acetaldehyde16340452
D000079Acetaldehyde[CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH2 mRNA22285649
D000079AcetaldehydeAcetaldehyde results in decreased expression of ALDH2 protein28017615
D000079AcetaldehydeALDH2 protein results in increased metabolism of Acetaldehyde11535626|1562989
D000079Acetaldehyde"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Acetaldehyde results in decreased expression of ALDH2 protein]"28017615
D000079Acetaldehyde"[N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of ALDH2 protein] which results in increased abundance of Acetaldehyde"19446252
D000079AcetaldehydeALDH2 protein results in increased metabolism of Acetaldehyde14615007
D000082AcetaminophenAcetaminophen results in decreased expression of ALDH2 mRNA25704631
D000082AcetaminophenAcetaminophen results in increased expression of ALDH2 protein21329376
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH2 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH2 mRNA]17585979
D000082AcetaminophenAcetaminophen affects the expression of ALDH2 mRNA15800402
D000082AcetaminophenAcetaminophen affects the expression of ALDH2 protein15800402|1668747
C038699acetophenoneacetophenone inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]10609638
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]17585900
D000171AcroleinAcrolein binds to and results in decreased activity of ALDH2 protein22339434
D000171AcroleinALDH2 protein results in increased oxidation of Acrolein22339434
D000171AcroleinNAD inhibits the reaction [Acrolein binds to and results in decreased activity of ALDH2 protein]22339434
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ALDH2 mRNA27153756
D000447AldehydesALDH2 gene mutant form results in decreased metabolism of and results in increased abundance of Aldehydes25155611
D000638AmiodaroneAmiodarone affects the expression of ALDH2 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ALDH2 mRNA16483693
C023650anilineaniline results in increased nitrosation of ALDH2 protein21708182
D001205Ascorbic AcidALDH2 protein affects the reaction [Ascorbic Acid deficiency results in decreased susceptibility to Nitroglycerin]23194305
D001280AtrazineAtrazine results in increased expression of ALDH2 mRNA22378314
D001542BenomylBenomyl metabolite results in decreased activity of ALDH2 protein10513990
D001542BenomylBenomyl results in decreased activity of ALDH2 protein9585485
D001542BenomylBenomyl results in decreased activity of ALDH2 protein11142365|1533176
C032175benzaldehydeALDH2 protein results in increased metabolism of benzaldehyde11744614
C032175benzaldehydebenzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]10609638
D001547BenzaldehydesBenzaldehydes results in decreased activity of ALDH2 protein22079344
D001553BenzbromaroneBenzbromarone affects the expression of ALDH2 mRNA19483382
D001554BenzeneBenzene results in decreased expression of ALDH2 mRNA20036648
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ALDH2 protein29145655
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ALDH2 mRNA19770486|2012785
C031403benzyl isothiocyanatebenzyl isothiocyanate results in increased expression of ALDH2 mRNA28821405
C031403benzyl isothiocyanatebenzyl isothiocyanate results in increased expression of ALDH2 protein28821405
C031403benzyl isothiocyanateNFE2L2 protein promotes the reaction [benzyl isothiocyanate results in increased expression of ALDH2 mRNA]28821405
C038328BEP protocolBEP protocol results in increased expression of ALDH2 mRNA18987330|2320077
D004958EstradiolEstradiol affects the expression of ALDH2 mRNA14699072
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of ALDH2 protein]25150618
D001622Betaine[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein20118189
C006780bisphenol Abisphenol A results in increased expression of ALDH2 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ALDH2 mRNA25181051
C032036bromobenzenebromobenzene metabolite binds to ALDH2 protein17305373
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ALDH2 mRNA15336504
D020122tert-ButylhydroperoxideALDH2 protein results in decreased susceptibility to tert-Butylhydroperoxide15003993
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ALDH2 mRNA14729362|1500399
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ALDH2 mRNA18804290
C018475butyraldehydeALDH2 protein polymorphism affects the metabolism of butyraldehyde11744614
C018475butyraldehydebutyraldehyde results in decreased expression of ALDH2 mRNA26079696
D002104CadmiumCadmium results in increased oxidation of ALDH2 protein24496640
D002104CadmiumCadmium results in increased expression of ALDH2 mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ALDH2 mRNA18804290
D002118CalciumALDH2 protein inhibits the reaction [Ethanol affects the abundance of Calcium]17590987
D002220CarbamazepineCarbamazepine affects the expression of ALDH2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALDH2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ALDH2 protein15650968
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ALDH2 mRNA16239168
D002273CarcinogensCarcinogens results in decreased expression of ALDH2 mRNA22269147
D002697Chloral Hydrate[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin18272654
D002697Chloral Hydrate[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde21376711
D002697Chloral Hydrate[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde21376711
D002697Chloral Hydrate[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal21334317
D002697Chloral Hydrate[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde21334317
C004656chloroacetaldehydeALDH2 protein results in increased oxidation of chloroacetaldehyde23295226
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) affects the expression of ALDH2 mRNA18804290
D002737ChloropreneChloroprene results in increased expression of ALDH2 mRNA23125180
D002794Choline[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein20118189
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH2 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH2 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ALDH2 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ALDH2 mRNA]17585979
D002994ClofibrateClofibrate affects the expression of ALDH2 mRNA19483382
D003042Cocaine[ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine20729865
D003042CocaineALDH2 protein affects the reaction [Cocaine results in increased abundance of Dopamine]20729865
D003042Cocaine[[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]20729865
D009243NADALDH2 protein binds to NAD23295226
D009243NAD[ALDH2 protein co-treated with NAD] results in increased oxidation of Retinaldehyde10559215
D009243NADNAD inhibits the reaction [Acrolein binds to and results in decreased activity of ALDH2 protein]22339434
D009243NADALDH2 gene polymorphism affects the abundance of NAD15900217
D009243NADALDH2 protein affects the abundance of NAD15900217
D009243NADALDH2 protein binds to NAD15900217
D009243NADMagnesium affects the reaction [NAD binds to ALDH2 protein]21276780
D009243NADNAD binds to ALDH2 protein15629893|2127678
D009249NADP1-benzylimidazole inhibits the reaction [NADP promotes the reaction [Thiocarbamates analog results in decreased activity of ALDH2 protein]]9585485
D009249NADPNADP promotes the reaction [Thiocarbamates analog results in decreased activity of ALDH2 protein]9585485
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of ALDH2 protein]25150618
D003300CopperCopper deficiency affects the expression of ALDH2 protein25150618
D003300CopperCopper affects the expression of ALDH2 mRNA23825565
D003300CopperCopper results in decreased expression of ALDH2 mRNA22465980
D003407CreosoteCreosote results in increased expression of ALDH2 mRNA19389177
D003471CuprizoneCuprizone results in increased expression of ALDH2 mRNA26577399
C550386CVT-10216[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline20729865
C550386CVT-10216[[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]20729865
C550386CVT-10216CVT-10216 results in decreased activity of ALDH2 protein20729865
D003484Cyanamide[Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin18272654
D003484CyanamideCyanamide results in decreased activity of ALDH2 protein14690875|1957688
D003520CyclophosphamideCyclophosphamide results in increased expression of ALDH2 mRNA17403535
D016572CyclosporineCyclosporine results in decreased expression of ALDH2 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in increased expression of ALDH2 mRNA21163907|2798913
D016572CyclosporineCyclosporine results in decreased expression of ALDH2 mRNA23830897
C013908daidzindaidzin inhibits the reaction [ALDH2 protein results in increased hydrolysis of 4-nitrophenyl acetate]21349255
C013908daidzindaidzin inhibits the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]21349255
C013908daidzindaidzin results in decreased activity of ALDH2 protein25601988
D000069439DasatinibDasatinib results in increased expression of ALDH2 mRNA20579391
C021170decanaldehydeALDH2 protein results in increased metabolism of decanaldehyde11744614
C014347decitabinedecitabine results in increased expression of ALDH2 mRNA19194470
D003907DexamethasoneDexamethasone results in increased expression of ALDH2 mRNA21041162
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ALDH2 mRNA17379624|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ALDH2 mRNA27392435
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ALDH2 protein27070252
D004041Dietary Fatsresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ALDH2 protein]27070252
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ALDH2 protein27070252
D019422Dietary Sucroseresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ALDH2 protein]27070252
C014476diethyl maleatediethyl maleate results in decreased reduction of ALDH2 protein19843705
C014476diethyl maleatediethyl maleate results in decreased expression of ALDH2 protein21161181
C014476diethyl maleatediethyl maleate results in increased expression of ALDH2 protein21161181
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ALDH2 mRNA21041162
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of ALDH2 mRNA23876855
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ALDH2 mRNA"22485181
D004221DisulfiramDisulfiram results in decreased activity of ALDH2 protein22079344
D004221DisulfiramDisulfiram metabolite results in decreased activity of ALDH2 protein10513990
D004221DisulfiramDisulfiram results in decreased activity of ALDH2 protein9585485
D004221DisulfiramDisulfiram results in decreased activity of ALDH2 protein11142365|2449663
D004221Disulfiram[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde21376711
D004221Disulfiram[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde21376711
D004221Disulfiram[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal21334317
D004221Disulfiram[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid21376711
D004221Disulfiram[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde21334317
D004221DisulfiramDisulfiram results in decreased expression of ALDH2 mRNA24496638
D004237DiuronDiuron results in decreased expression of ALDH2 mRNA21551480
D004298DopamineALDH2 protein affects the reaction [Cocaine results in increased abundance of Dopamine]20729865
D004298Dopamine[[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]20729865
D004317DoxorubicinALDH2 protein results in decreased susceptibility to Doxorubicin22079344
D004391DustDust results in decreased expression of ALDH2 mRNA17805423
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of ALDH2 mRNA24534155
C036251EPTCEPTC metabolite results in decreased activity of ALDH2 protein10513990
D000431EthanolALDH2 gene polymorphism affects the susceptibility to Ethanol15840430|2296099
D000431EthanolALDH2 protein affects the susceptibility to Ethanol10780266
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]19429258
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in decreased expression of NOL3 protein]19429258
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in decreased phosphorylation of GSK3B protein]19429258
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein]19429258
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of BAX protein]19429258
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of CASP8 protein]19429258
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of HTRA2 protein]19429258
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of XIAP protein]19429258
D000431EthanolALDH2 protein results in decreased susceptibility to Ethanol19429258
D000431EthanolALDH2 protein results in increased metabolism of Ethanol10064379|1082610
D000431EthanolALDH2 protein results in increased susceptibility to Ethanol15840430
D000431EthanolEthanol results in increased expression of ALDH2 mRNA22056336
D000431Ethanolresveratrol promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA]22056336
D000431EthanolALDH2 gene mutant form results in increased susceptibility to Ethanol25155611
D000431EthanolALDH2 protein inhibits the reaction [Ethanol affects the abundance of Calcium]17590987
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased activity of CASP3 protein]19332462
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of NCF1 protein]19332462
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased expression of PPP3CA protein]19332462
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of CREB1 protein]19332462
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GATA4 protein]19332462
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GSK3B protein]19332462
D000431EthanolALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of MAP3K5 protein]19332462
D000431Ethanol[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein20118189
D000431EthanolEthanol results in increased activity of ALDH2 protein22022451
D000431EthanolEthanol results in increased expression of ALDH2 mRNA22554647
D000431Ethanoltaraxerone promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA]22554647
D000431Ethanol[Zinc co-treated with Ethanol] results in increased expression of ALDH2 mRNA19637192
D000431EthanolALDH2 protein affects the susceptibility to Ethanol12439222
D000431EthanolEthanol inhibits the reaction [Streptozocin results in decreased expression of ALDH2]23500772
D000431EthanolEthanol results in increased activity of ALDH2 protein23500772
D000431EthanolEthanol results in increased expression of ALDH2 protein23200777
D000431Ethanol"[N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of ALDH2 protein] which results in increased susceptibility to Ethanol"19446252
D005001EthionineEthionine affects the expression of ALDH2 mRNA19483382
C098546ethyl tert-butyl etherALDH2 protein affects the susceptibility to ethyl tert-butyl ether22102104|2444883
C098546ethyl tert-butyl etherALDH2 results in decreased susceptibility to ethyl tert-butyl ether23810710
D005485FlutamideFlutamide results in increased expression of ALDH2 protein17311803
D005492Folic Acid[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein20118189
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH2 mRNA20938992
D005557Formaldehyde"2,6-dichloro-4-nitrophenol inhibits the reaction [ALDH2 protein results in increased metabolism of Formaldehyde]"19822198
D005557FormaldehydeALDH2 protein affects the metabolism of Formaldehyde19115622
D005557FormaldehydeALDH2 protein polymorphism affects the metabolism of Formaldehyde11744614
D005557FormaldehydeALDH2 protein results in increased metabolism of Formaldehyde19822198
D005557FormaldehydeALDH2 protein results in decreased susceptibility to Formaldehyde21276436
C039281furanfuran binds to ALDH2 protein22240984
C039281furanfuran results in decreased expression of ALDH2 mRNA25539665|2619464
D005839GentamicinsGentamicins results in decreased expression of ALDH2 mRNA22061828
D005839GentamicinsGentamicins results in decreased expression of ALDH2 protein22061828
D005897GlafenineGlafenine results in decreased expression of ALDH2 mRNA24136188
D005947GlucoseGlucose results in decreased expression of ALDH2 protein29128638
D005947Glucose"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ALDH2 protein]"29128638
D005985Glyceraldehyde[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde21376711
D005985Glyceraldehyde[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde21376711
C010972glycolaldehyde[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde21376711
C010972glycolaldehyde[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde21376711
D006037Glyoxal[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal21334317
D006037Glyoxal[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal21334317
D006152Cyclic GMPALDH2 protein affects the reaction [Nitroglycerin results in decreased abundance of Cyclic GMP]17585900
C412815GW 4064GW 4064 results in decreased expression of ALDH2 protein23178280
D006427HeminHemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]17541025
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of ALDH2 mRNA20566314
C031927hydroquinonehydroquinone results in increased expression of ALDH2 mRNA15452088
C012375hydroxypyruvic acid[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to hydroxypyruvic acid21376711
C492448ICG 001ICG 001 results in increased expression of ALDH2 mRNA26191083
D000068877Imatinib Mesylate[Imatinib Mesylate co-treated with tetraarsenic tetrasulfide] results in decreased expression of ALDH2 mRNA19208803
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of ALDH2 mRNA19208803
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH2 mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of ALDH2 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ALDH2 mRNA27392435
D007783LactonesLactones analog inhibits the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]25641190
D007783LactonesLactones analog results in decreased activity of ALDH2 protein25641190
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ALDH2 mRNA"11578593
C482199lipopolysaccharide, E coli O55-B5"pyrrolidine dithiocarbamic acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ALDH2 mRNA]"11578593
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ALDH2 protein"25149594
D008274MagnesiumMagnesium promotes the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]23295226
D008274MagnesiumMagnesium affects the activity of ALDH2 protein21276780
D008274MagnesiumMagnesium affects the reaction [NAD binds to ALDH2 protein]21276780
D008315MalondialdehydeALDH2 protein results in increased oxidation of Malondialdehyde22339434
C013099mancozebmancozeb results in decreased activity of ALDH2 protein17010440
D008344ManebManeb results in decreased activity of ALDH2 protein17010440
C054487menthofuranmenthofuran metabolite binds to and results in decreased activity of ALDH2 protein23106769
D008694MethamphetamineMethamphetamine results in decreased expression of ALDH2 mRNA15644446
D008715Methionine[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein20118189
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ALDH2 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ALDH2 mRNA18804290
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ALDH2 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of ALDH2 protein"19446252
D018817N-Methyl-3,4-methylenedioxyamphetamine"[N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of ALDH2 protein] which results in increased abundance of Acetaldehyde"19446252
D018817N-Methyl-3,4-methylenedioxyamphetamine"[N-Methyl-3,4-methylenedioxyamphetamine results in decreased activity of ALDH2 protein] which results in increased susceptibility to Ethanol"19446252
D008942MitoxantroneALDH2 protein affects the susceptibility to Mitoxantrone16217747
C009821molinatemolinate inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]20954713
C009821molinatemolinate metabolite binds to and results in decreased activity of ALDH2 protein20954713
C009821molinatemolinate metabolite inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]20954713
C553160molinate sulfoxidemolinate sulfoxide inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]20954713
D009153MutagensMutagens results in decreased expression of ALDH2 mRNA22269147
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased activity of ALDH2 protein"25263579
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"ALDH2 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of ALDH2 protein]"28017615
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"ALDH2 protein affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of BMP2 protein]"28017615
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Acetaldehyde results in decreased expression of ALDH2 protein]"28017615
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ALDH2 protein]"29128638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased activity of ALDH2 protein"24496638
C531525N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide"N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide results in increased expression of ALDH2 protein"28017615|2912863
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ALDH2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ALDH2 mRNA"25554681
C031721naphthalenenaphthalene metabolite binds to ALDH2 protein16453347
C031721naphthaleneCFTR gene mutant form affects the reaction [naphthalene results in decreased expression of ALDH2 protein]19438287
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of ALDH2 protein19438287
C031721naphthalenenaphthalene results in decreased expression of ALDH2 protein19438287
C031721naphthalenenaphthalene results in decreased reduction of ALDH2 protein19843705
C031721naphthalenenaphthalene results in increased reduction of ALDH2 protein19843705
C053320n-butoxyacetaldehydeALDH2 protein results in increased oxidation of n-butoxyacetaldehyde18940187
C066471NCS 382NCS 382 results in increased expression of ALDH2 mRNA28119166
C010463n-hexanalALDH2 protein polymorphism affects the metabolism of n-hexanal11744614
D009532NickelNickel results in increased expression of ALDH2 mRNA24084258
C022838nickel chloridenickel chloride affects the expression of ALDH2 mRNA21496282
D009569Nitric Oxide[ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide21156756
D009569Nitric OxideALDH2 protein results in increased abundance of Nitric Oxide21523859
D009569Nitric OxideALDH2 protein results in increased chemical synthesis of Nitric Oxide16440063|2153675
D005996Nitroglycerin[1-aminocyclopropanol analog results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin18272654
D005996NitroglycerinAcetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]17585900
D005996NitroglycerinALDH2 gene polymorphism affects the susceptibility to Nitroglycerin16440063
D005996NitroglycerinALDH2 protein affects the metabolism of Nitroglycerin18272654
D005996NitroglycerinALDH2 protein affects the reaction [Nitroglycerin results in decreased abundance of Cyclic GMP]17585900
D005996NitroglycerinALDH2 protein affects the susceptibility to Nitroglycerin17967228
D005996NitroglycerinALDH2 protein polymorphism affects the susceptibility to Nitroglycerin19576883
D005996Nitroglycerin[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin18272654
D005996Nitroglycerin[Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin18272654
D005996NitroglycerinNitroglycerin results in decreased activity of ALDH2 protein17585900
D005996NitroglycerinALDH2 protein affects the reaction [Ascorbic Acid deficiency results in decreased susceptibility to Nitroglycerin]23194305
D005996NitroglycerinALDH2 protein results in increased susceptibility to Nitroglycerin21156756
D005996NitroglycerinNitroglycerin results in decreased activity of ALDH2 protein17092343|2115675
D005996NitroglycerinALDH2 protein affects the metabolism of and results in increased activity of Nitroglycerin15331769
D005996NitroglycerinALDH2 protein affects the reaction [Nitroglycerin results in increased abundance of Reactive Oxygen Species]17493633
D005996NitroglycerinHemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]17541025
D005996NitroglycerinNitroglycerin results in decreased activity of ALDH2 protein15331769|1749363
D005996NitroglycerinNitroglycerin results in decreased expression of ALDH2 mRNA17493633
D005996NitroglycerinNitroglycerin results in decreased expression of ALDH2 protein17493633|1754102
D005996NitroglycerinALDH2 protein affects the metabolism of Nitroglycerin16051882
D005996NitroglycerinALDH2 protein results in increased metabolism of Nitroglycerin21523859
D005996NitroglycerinALDH2 protein results in increased reduction of Nitroglycerin21536753
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of ALDH2 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of ALDH2 protein19716841
D009853OmeprazoleOmeprazole affects the expression of ALDH2 mRNA19483382
D010269ParaquatParaquat results in decreased expression of ALDH2 mRNA18198484
D010417Pentaerythritol Tetranitrate[ALDH2 protein affects the metabolism of and results in increased susceptibility to Pentaerythritol Tetranitrate] which results in increased abundance of Nitric Oxide21156756
D010417Pentaerythritol TetranitrateALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate21156756
D010417Pentaerythritol Tetranitrate[ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol21156756
D010417Pentaerythritol TetranitrateALDH2 protein results in increased susceptibility to Pentaerythritol Tetranitrate21156756
D010417Pentaerythritol TetranitrateALDH2 protein affects the metabolism of and results in increased activity of Pentaerythritol Tetranitrate15331769
C100210pentrinitrol[ALDH2 protein results in increased metabolism of Pentaerythritol Tetranitrate] which results in increased chemical synthesis of pentrinitrol21156756
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of ALDH2 protein26168851
C522391perfluorododecanoic acidPPARA mRNA promotes the reaction [perfluorododecanoic acid results in decreased expression of ALDH2 protein]26168851
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ALDH2 protein26178269
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ALDH2 mRNA19162173
C011272perfosfamideALDH2 protein results in decreased susceptibility to perfosfamide22079344
C013190phenacyl bromidephenacyl bromide inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]10609638
D010634PhenobarbitalPhenobarbital affects the expression of ALDH2 mRNA23091169
D010695PhlorhizinPhlorhizin results in decreased expression of ALDH2 mRNA22538082
D010695PhlorhizinPhlorhizin results in increased expression of ALDH2 mRNA22538082
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ALDH2 mRNA15728792
C006253pirinixic acidpirinixic acid results in decreased expression of ALDH2 protein15226431
C006253pirinixic acidpirinixic acid affects the expression of ALDH2 mRNA19483382
D010936Plant ExtractsPlant Extracts results in increased expression of ALDH2 mRNA23557933
C045950propiconazolepropiconazole results in decreased expression of ALDH2 mRNA21278054
C045950propiconazolepropiconazole results in increased metabolism of ALDH2 protein19714882
C005556propionaldehydeALDH2 protein polymorphism affects the metabolism of propionaldehyde11744614
C005556propionaldehydeALDH2 protein results in increased metabolism of propionaldehyde20954713
C005556propionaldehydeALDH2 protein results in increased oxidation of propionaldehyde21349255|2329522
C005556propionaldehydedaidzin inhibits the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]21349255
C005556propionaldehydeMagnesium promotes the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]23295226
C005556propionaldehydemolinate inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]20954713
C005556propionaldehydemolinate metabolite inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]20954713
C005556propionaldehydemolinate sulfoxide inhibits the reaction [ALDH2 protein results in increased metabolism of propionaldehyde]20954713
C005556propionaldehydeLactones analog inhibits the reaction [ALDH2 protein results in increased oxidation of propionaldehyde]25641190
D011441PropylthiouracilPropylthiouracil affects the expression of ALDH2 mRNA19483382
C083295prunetinprunetin results in decreased activity of ALDH2 protein11142365
C020972pyrrolidine dithiocarbamic acid"pyrrolidine dithiocarbamic acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of ALDH2 mRNA]"11578593
D011765Pyruvaldehyde[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde21334317
D011765Pyruvaldehyde[Disulfiram results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde21334317
D011794QuercetinQuercetin results in decreased expression of ALDH2 mRNA21632981
D011794QuercetinQuercetin affects the expression of ALDH2 mRNA16455785
C502851quinocetonequinocetone results in decreased expression of ALDH2 protein27046791
C502851quinocetonequinocetone results in increased expression of ALDH2 protein27046791
D017382Reactive Oxygen SpeciesALDH2 protein affects the reaction [Nitroglycerin results in increased abundance of Reactive Oxygen Species]17493633
C059514resveratrolresveratrol promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA]22056336
C059514resveratrolresveratrol results in increased expression of ALDH2 mRNA22056336
C059514resveratrolresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ALDH2 protein]27070252
C059514resveratrolresveratrol results in increased expression of ALDH2 protein25505154
D012172Retinaldehyde[ALDH2 protein co-treated with NAD] results in increased oxidation of Retinaldehyde10559215
D012172RetinaldehydeALDH2 protein results in increased metabolism of Retinaldehyde11744614
C089730rosiglitazonerosiglitazone results in increased expression of ALDH2 mRNA15520860
D012402RotenoneALDH2 protein inhibits the reaction [Rotenone results in increased abundance of 4-hydroxy-2-nonenal]25263579
D012402RotenoneALDH2 protein inhibits the reaction [Rotenone results in increased activity of CASP3 protein]25263579
D012402RotenoneALDH2 protein inhibits the reaction [Rotenone results in increased activity of CASP9 protein]25263579
D012402RotenoneALDH2 protein inhibits the reaction [Rotenone results in increased expression of BAX protein]25263579
C079198S 1 (combination)ALDH2 protein results in increased susceptibility to S 1 (combination)16734730
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ALDH2 mRNA25895662
D012834SilverSilver results in increased expression of ALDH2 mRNA27131904
C121734S-methyl-N-butylthiocarbamate sulfoxideS-methyl-N-butylthiocarbamate sulfoxide results in decreased activity of ALDH2 protein9585485
D012906SmokeALDH2 gene polymorphism affects the susceptibility to Smoke25978981
C009277sodium arsenatesodium arsenate results in decreased expression of ALDH2 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of ALDH2 mRNA20886546|2387685
C017947sodium arsenitesodium arsenite results in decreased expression of ALDH2 mRNA18812580
D012969Sodium FluorideSodium Fluoride results in decreased expression of ALDH2 protein27548804
D013311StreptozocinEthanol inhibits the reaction [Streptozocin results in decreased expression of ALDH2]23500772
D013311StreptozocinStreptozocin results in decreased expression of ALDH2 mRNA23500772
D013311StreptozocinStreptozocin results in decreased expression of ALDH2 protein23500772
D013311StreptozocinStreptozocin results in increased expression of ALDH2 protein21136691
D016559TacrolimusTacrolimus results in decreased expression of ALDH2 mRNA25270620
C009379taraxeronetaraxerone promotes the reaction [Ethanol results in increased expression of ALDH2 mRNA]22554647
C534735tetraarsenic tetrasulfide[Imatinib Mesylate co-treated with tetraarsenic tetrasulfide] results in decreased expression of ALDH2 mRNA19208803
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ALDH2 mRNA19692669|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ALDH2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ALDH2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH2 mRNA25613284
D013765Tetrahydropapaveroline[ALDH2 protein affects the abundance of Tetrahydropapaveroline] which affects the susceptibility to Cocaine20729865
D013765Tetrahydropapaveroline[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline20729865
D013765Tetrahydropapaveroline[[CVT-10216 results in decreased activity of ALDH2 protein] which results in increased abundance of Tetrahydropapaveroline] inhibits the reaction [Cocaine results in increased abundance of and results in increased secretion of Dopamine]20729865
D013853ThioacetamideThioacetamide affects the expression of ALDH2 mRNA19483382
D013859Thiocarbamates1-benzylimidazole inhibits the reaction [NADP promotes the reaction [Thiocarbamates analog results in decreased activity of ALDH2 protein]]9585485
D013859ThiocarbamatesNADP promotes the reaction [Thiocarbamates analog results in decreased activity of ALDH2 protein]9585485
D013859ThiocarbamatesThiocarbamates analog results in decreased activity of ALDH2 protein9585485
C009495titanium dioxidetitanium dioxide results in decreased expression of ALDH2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ALDH2 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ALDH2 protein22609517|2731939
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ALDH2 protein24486158
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone results in decreased activity of ALDH2 protein11142365
D014212TretinoinTretinoin results in increased expression of ALDH2 mRNA20530235
D014212TretinoinTretinoin results in increased expression of ALDH2 mRNA16249480
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ALDH2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of ALDH2 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of ALDH2 protein18495193
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ALDH2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ALDH2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of ALDH2 mRNA20546886
D014638VanadatesVanadates results in decreased expression of ALDH2 mRNA22714537
D014640VancomycinVancomycin results in increased expression of ALDH2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ALDH2 gene25560391
C025643vinclozolinvinclozolin affects the expression of ALDH2 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of ALDH2 protein20616205
D014752Vinyl ChlorideALDH2 gene SNP results in increased susceptibility to Vinyl Chloride20100738
D014805Vitamin B 12[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein20118189
D024483Vitamin K 3Vitamin K 3 affects the expression of ALDH2 mRNA20044591
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ALDH2 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of ALDH2 mRNA26272509
D015032Zinc[Zinc co-treated with Ethanol] results in increased expression of ALDH2 mRNA19637192
D019287Zinc Sulfate[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein20118189

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004029aldehyde dehydrogenase (NAD) activity-EXP18196  4065146  
GO:0004029aldehyde dehydrogenase (NAD) activity-IBA21873635  
GO:0004029aldehyde dehydrogenase (NAD) activity-IDA4015840  
GO:0004030aldehyde dehydrogenase [NAD(P)+] activity-TAS8903321  
GO:0009055electron transfer activity-TAS8903321  
GO:0043878glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity-IEA-  
GO:0051287NAD binding-ISS12693930  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-TAS8903321  
GO:0006066alcohol metabolic process-TAS1306115  
GO:0006068ethanol catabolic process-IEA-  
GO:0006069ethanol oxidation-TAS-  
GO:0022900electron transport chain-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00040Pentose and glucuronate interconversions
hsa00053Ascorbate and aldarate metabolism
hsa00071Fatty acid degradation
hsa00280Valine, leucine and isoleucine degradation
hsa00310Lysine degradation
hsa00330Arginine and proline metabolism
hsa00340Histidine metabolism
hsa00380Tryptophan metabolism
hsa00410beta-Alanine metabolism
hsa00561Glycerolipid metabolism
hsa00620Pyruvate metabolism
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-112311Neurotransmitter clearanceTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-380612Metabolism of serotoninTAS
R-HSA-380615Serotonin clearance from the synaptic cleftTAS
R-HSA-71384Ethanol oxidationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11238183Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. (2001 Mar)Yokoyama ACarcinogenesis
23009284Factors associated with the presence of multiple Lugol-voiding lesions in patients with esophageal squamous-cell carcinoma. (2014 Jul)Katada CDis Esophagus
15112932Biological and behavioral markers of alcohol sensitivity. (2004 Feb)Fromme KAlcohol Clin Exp Res
15066702Workshop on Alcohol Use and Health Disparities 2002: a call to arms. (2004 Jan)Russo DAlcohol
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer
20626721Association of ADH4 genetic variants with alcohol dependence risk and related phenotypes: results from a larger multicenter association study. (2011 Apr)Preuss UWAddict Biol
25427912Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers. (2015)Yokoyama AAdv Exp Med Biol
14506399Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers. (2003 Sep)Yokoyama MAlcohol Clin Exp Res
16624836ALDH2 promoter polymorphism has no effect on the risk for alcoholism. (2006 Jul-Aug)Kimura MAlcohol Alcohol
26734919Ethanol metabolism, toxicity and genetic polymorphism. (1998 Jul)Iwahashi KAddict Biol
27187070Phenome-Wide Association Study for Alcohol and Nicotine Risk Alleles in 26394 Women. (2016 Oct)Polimanti RNeuropsychopharmacology
21900886Pharmacogenetics of naltrexone in asian americans: a randomized placebo-controlled laboratory study. (2012 Jan)Ray LANeuropsychopharmacology
15511718Relation of genotypes of alcohol metabolizing enzymes and mortality of liver diseases in patients with alcohol dependence. (2004 Sep-Dec)Chen CCAddict Biol
28160209Increased expression of microRNA-378a-5p in acute ethanol exposure of rat cardiomyocytes. (2017 Mar)Wang ZCell Stress Chaperones
12119207Genetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels. (2002 Sep)Nakamura YAtherosclerosis
19393179Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487Lys. (2009 Apr 15)Luo HRGene
21118274Role of GABRA2 in moderating subjective responses to alcohol. (2011 Mar)Roh SAlcohol Clin Exp Res
24201835Polymorphisms in the aldehyde dehydrogenase 2 and dopamine beta hydroxylase genes are not associated with Alzheimer's disease. (2014 Apr)Komatsu MJ Neural Transm (Vienna)
9726271Self-reported flushing and genotypes of ALDH2, ADH2, and ADH3 among Taiwanese Han. (1998 Aug)Chen WJAlcohol Clin Exp Res
10630602Alcohol metabolism and cardiovascular response in an alcoholic patient homozygous for the ALDH2*2 variant gene allele. (1999 Dec)Chen YCAlcohol Clin Exp Res
7573775CYP2E1 and ALDH2 genotypes and alcohol dependence in Japanese. (1995 Jun)Iwahashi KAlcohol Clin Exp Res
25419637No association between the ALDH2 promoter polymorphism rs886205, alcohol dependence, and risky alcohol consumption in a German population. (2015 Feb)Haschemi Nassab MPsychiatr Genet
12893989Mutations in mitochondrial aldehyde dehydrogenase (ALDH2) change cofactor affinity and segregate with voluntary alcohol consumption in rats. (2003 Aug)Sapag APharmacogenetics
17285601Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. (2007 May)Matsuo KHum Mutat
25978981Association between the aldehyde dehydrogenase 2*2 allele and smoking-related chronic airway obstruction in a Japanese general population: a pilot study. (2015 Jul 16)Morita KToxicol Lett
10971205Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (2000 Sep)Vasiliou VPharmacology
12824808Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. (2003 Jun)Lu RBAlcohol Clin Exp Res
16759795p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma. (2007 Mar 18)Yokoyama ACancer Lett
10459742Aldehyde dehydrogenase genotypes and male alcohol use disorders: a case-control study in Khon Kaen, north-east Thailand. (1999 Jun)Nanakorn SPsychiatry Clin Neurosci
17590991The determination of acetaldehyde in exhaled breath. (2007)Tardif RNovartis Found Symp
18056758Major genetic components underlying alcoholism in Korean population. (2008 Mar 15)Kim DJHum Mol Genet
27986911Aldehyde Dehydrogenase 2 Polymorphism Is a Predictor of Smoking Cessation. (2017 Sep 1)Masaoka HNicotine Tob Res
7645026Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. (1995 Aug)Kawamoto TToxicol Appl Pharmacol
23134043Identifying genetic variation for alcohol dependence. (2012)Agrawal AAlcohol Res
23296215Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism. (2013 Mar-Apr)Yokoyama AAlcohol Alcohol
8612062Candidate genes in alcoholism. (1995)Goldman DClin Neurosci
15714130Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population. (2005 Mar)Miyasaka KPancreas
19182438Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects. (2009 Feb)Kimura YJ Toxicol Sci
21848961Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism. (2011 Nov)Kimura MAlcohol Clin Exp Res
11051375Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. (2000 Oct)Chao YCAm J Gastroenterol
22102315Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. (2012 May)Li DHum Genet
25175613A Study on Polymorphism Affecting Excretion of Urinary Methylhippuric Acid due to Xylene Exposure. (2004 Nov)Kim CSJ Prev Med Public Health
10780266Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. (1999 Aug)Peng GSPharmacogenetics
8709585Investigator-observed alcohol-induced flushing but not self-report of flushing is a valid predictor of ALDH2 genotype. (1996 May)Wall TLJ Stud Alcohol
24220019Genetic influences on response to alcohol and response to pharmacotherapies for alcoholism. (2014 Aug)Enoch MAPharmacol Biochem Behav
9608230[Genetic evaluation of tolerance to alcohol]. (1998)Chrostek LPostepy Hig Med Dosw
17718394The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. (2007)Edenberg HJAlcohol Res Health
21609394mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. (2012 Mar)Ge WJ Cell Mol Med
19014920Polymorphism of ethanol-metabolism genes and alcoholism: correlation of allelic variations with the pharmacokinetic and pharmacodynamic consequences. (2009 Mar 16)Chen YCChem Biol Interact
24567230Haplotype-based study of the association of alcohol and acetaldehyde-metabolising genes with alcohol dependence (with or without comorbid anxiety symptoms) in a Cape Mixed Ancestry population. (2014 Jun)Crawford AMetab Brain Dis
28212515Combination of ALDH2 and ADH1B polymorphisms is associated with smoking initiation: A large-scale cross-sectional study in a Japanese population. (2017 Apr 1)Masaoka HDrug Alcohol Depend
19861527Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. (2009 Nov)Oze ICancer Epidemiol Biomarkers Prev
22458712A health-risk appraisal model and endoscopic mass screening for esophageal cancer in Japanese men. (2013 Feb-Mar)Yokoyama ADis Esophagus
17952709Single nucleotide polymorphisms of the ALDH2 gene in six Indian populations. (2007 Nov-Dec)Bhaskar LVAnn Hum Biol
23667679Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history. (2013)Aida JPLoS One
11956970Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. (2002 Apr)Hasegawa YJ Neural Transm (Vienna)
23243119Is aldehyde dehydrogenase 2 a credible genetic instrument for alcohol use in Mendelian randomization analysis in Southern Chinese men? (2013 Feb)Au Yeung SLInt J Epidemiol
8651462Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2. I. A comparison of the genotypes of ALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics. (1996 Feb)Nakamura KAlcohol Clin Exp Res
27087413Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men. (2016 Jun)Yokoyama AAlcohol Clin Exp Res
15041893Current concepts in alcohol metabolism. (2003 Apr-Jun)Caballeria JAnn Hepatol
192514545HTT polymorphisms are associated with job stress in Japanese workers. (2009 Apr)Katsuyama HLeg Med (Tokyo)
91188768-Hydroxydeoxyguanosine in human leukocyte DNA and daily health practice factors: effects of individual alcohol sensitivity. (1996 Dec)Nakajima MEnviron Health Perspect
28052001Genetic polymorphisms in ALDH2 are associated with drug addiction in a Chinese Han population. (2017 Jan 31)Zhang COncotarget
23990377Introduction to deep sequencing and its application to drug addiction research with a focus on rare variants. (2014 Feb)Wang SMol Neurobiol
25448285Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients. (2015 Jan 5)Morita KToxicol Lett
15542751Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders. (2004 Oct)Higuchi SAnn N Y Acad Sci
18258609A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. (2008 Jun)Zienolddiny SCarcinogenesis
28729482BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. (2017 Oct)Tacconi EMEMBO Mol Med
7779096Dopamine transporter gene polymorphism and alcoholism. (1995 Jun 6)Muramatsu TBiochem Biophys Res Commun
26848198Characterization of polymorphisms of genes ADH2, ADH3, ALDH2 and CYP2E1 and relationship to the alcoholism in a Colombian population. (2015 Dec 30)Mendez CColomb Med (Cali)
28805974Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population. (2017 Aug)Katsarou MSPharmacol Res Perspect
20025435Alcohol and aldehyde dehydrogenase polymorphisms in Chinese and Indian populations. (2010)Tan ECSubst Use Misuse
16679777Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. (2006)Nishizawa DNeuropsychobiology
12439222Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. (2002 Nov)Isse TPharmacogenetics
12138721[Relationship between ethanol patch test and problem drinkers among dental students]. (2002 Jun)Watanabe HNihon Arukoru Yakubutsu Igakkai Zasshi
24680035Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study. (2014 Jun)Ahrens WOral Oncol
29063269Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence. (2018 May)Yokoyama AJ Gastroenterol
23891816S-(N, N-diethylcarbamoyl)glutathione (carbamathione), a disulfiram metabolite and its effect on nucleus accumbens and prefrontal cortex dopamine, GABA, and glutamate: a microdialysis study. (2013 Dec)Faiman MDNeuropharmacology
11515253Association between smoking, acetaldehyde dehydrogenase-2 1-1 status, and alcohol drinking among Taiwanese polyvinyl chloride workers. (2001 Aug)Lin YPJ Occup Environ Med
21083667Haplotype-based study of the association of alcohol-metabolizing genes with alcohol dependence in four independent populations. (2011 Feb)Liu JAlcohol Clin Exp Res
28578603AAV Gene Therapy for Alcoholism: Inhibition of Mitochondrial Aldehyde Dehydrogenase Enzyme Expression in Hepatoma Cells. (2017 Sep)Sanchez ACHum Gene Ther
26033520Comorbid alcohol dependence disorder may be related to aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) in bipolar II disorder, but only to ALDH2 in bipolar I disorder, in Han Chinese. (2015 Aug)Chang YHBipolar Disord
7904979Polymorphism of alcohol and aldehyde dehydrogenase genes and alcoholic cirrhosis in Chinese patients. (1994 Feb)Chao YCHepatology
29582627ADH1B, ALDH2, GSTM1 and GSTT1 Gene Polymorphic Frequencies among Alcoholics and Controls in the Arcadian Population of Central India (2018 Mar 27)Mansoori AAAsian Pac J Cancer Prev
10954050Dipole estimation of alpha EEG during alcohol ingestion in males genotypes for ALDH2. (2000)Hara KLife Sci
21432543Effect of gene polymorphisms and ethanol consumption on micronucleus frequency in human reticulocytes: a preliminary study. (2010 May)Wu CEnviron Health Prev Med
12223435Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers. (2002 Sep)Yokoyama ACancer Epidemiol Biomarkers Prev
12495467Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China. (2002 Dec)Yu SZJpn J Cancer Res
27038040ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma. (2016 Jul)Kagemoto KCancer Med
12505800Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians. (2003 Jan)Wall TLAm J Psychiatry
28361821Candidate genes for alcohol dependence: A genetic association study from India. (2016 Nov)Malhotra SIndian J Med Res
10224678ADH and ALDH polymorphisms among Alaska Natives entering treatment for alcoholism. (1999 Jan-Mar)Segal BAlaska Med
28485404Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. (2017 Sep)Jorgenson EMol Psychiatry
22674532Risk of superficial squamous cell carcinoma developing in the head and neck region in patients with esophageal squamous cell carcinoma. (2012 Jun)Katada CLaryngoscope
17134659Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population. (2006 Jun)Montano Loza AJAlcohol
7718681Heterozygous for ALDH2 in alcohol dependence: relationship between the ALDH2 genotype and personality disorder in alcohol-dependent patients with the Flushing syndrome. (1995 Jan 15)Iwahashi KBiol Psychiatry
26599441Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry. (2015)Idewaki YPLoS One
28430929Promoter Polymorphism rs886205 Genotype Interacts With DNA Methylation of the ALDH2 Regulatory Region in Alcohol Dependence. (2017 May 1)Pathak HAlcohol Alcohol
26862830Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer on the basis of the aldehyde dehydrogenase 2 genotype and alcohol consumption in a Japanese population. (2017 Jan)Koyanagi YNEur J Cancer Prev
12949054Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic men. (2003 Nov)Yokoyama ACarcinogenesis
11398342[Classification of alcohol metabolizing enzymes and polymorphisms--specificity in Japanese]. (2001 Apr)Harada SNihon Arukoru Yakubutsu Igakkai Zasshi
24661165Effects of ALDH2 *2 on alcohol problem trajectories of Asian American college students. (2014 Feb)Luczak SEJ Abnorm Psychol
17033202ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma. (2006)Hashimoto TTumour Biol
16600530Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women. (2006 Sep 15)Lorenzo ADrug Alcohol Depend
19262484Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. (2009 Mar)Tsuchihashi-Makaya MHypertens Res
29136221Facial flushing after alcohol intake as a predictor for a high risk of synchronous or metachronous cancer of the upper gastrointestinal tract. (2017 Dec 1)Harada HJpn J Clin Oncol
15122947ALDH2 status and conduct disorder mediate the relationship between ethnicity and alcohol dependence in Chinese, Korean, and White American college students. (2004 May)Luczak SEJ Abnorm Psychol
21940907Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. (2011 Nov)Hakenewerth AMCancer Epidemiol Biomarkers Prev
12517056Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes. (2002 Nov)Peng GSJ Formos Med Assoc
19302089MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (2009 Jun)Lee SYAlcohol Clin Exp Res
20590827Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer. (2010 Jul)Miyasaka KGeriatr Gerontol Int
22703173The genetics of substance dependence. (2012)Wang JCAnnu Rev Genomics Hum Genet
15519646Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. (2004 Nov)Vidal FJ Hepatol
19429258Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex. (2009 Jun 22)Ren JToxicol Lett
25270064Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample. (2014 Dec)Peng QAm J Med Genet B Neuropsychiatr Genet
18037339Genetic polymorphisms and micronucleus formation: a review of the literature. (2008 Mar-Apr)Iarmarcovai GMutat Res
26842247Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. (2016 Feb)Wu LSAlcohol Clin Exp Res
8834237Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2. (1996 Apr)Higuchi SHum Genet
12213289Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. (2002 Dec 5)Boonyaphiphat PCancer Lett
10803776Biological markers of alcoholism with respect to genotypes of low-Km aldehyde dehydrogenase (ALDH2) in Japanese subjects. (2000 Apr)Nomura FAlcohol Clin Exp Res
10942105The ALDH2 genotype, alcohol intake, and liver-function biomarkers among Japanese male workers. (2000 Jun)Takeshita THum Genet
11744614Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. (2002 Jan)Wang RSDrug Metab Dispos
19396661Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers. (2009)Salaspuro MScand J Gastroenterol
18331377Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (2008 May)Kuo PHAlcohol Clin Exp Res
12710951The ADH3*2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men. (2003 Apr)Konishi TExp Mol Pathol
25271825Asian flushing: genetic and sociocultural factors of alcoholism among East asians. (2014 Sep-Oct)Lee HGastroenterol Nurs
11375898Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. (2001 Jun)Matsuo KCarcinogenesis
21946912Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese. (2012 Mar)Matsuo KEur J Cancer Prev
21917409Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers. (2012 Feb)Pavanello SAlcohol
8986224Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. (1996 Dec)Matsumoto MAlcohol Clin Exp Res
1306115Molecular genetics of human aldehyde dehydrogenase. (1992 Aug)Yoshida APharmacogenetics
28937693Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). (2017 Oct)Clarke TKMol Psychiatry
19403456Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. (2009 Apr)Vaswani MHum Genomics
18798003Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans. (2009 Mar)Eom SYCancer Causes Control
22214999Reduction of ethanol consumption in alcohol-preferring rats by dual expression gene transfer. (2012 Mar-Apr)Rivera-Meza MAlcohol Alcohol
11347517[Genetics of addictive disorders]. (2000 Nov)Rothhammer FRev Med Chil
16440674[Interrelationship among factors associated with drinking behaviors in dental students]. (2005 Dec)Watanabe HNihon Arukoru Yakubutsu Igakkai Zasshi
8985275Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. (1997 Jan)Chao YCHepatology
22155604The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese. (2011 Oct)Yao CTHum Genomics
19124505Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach. (2009 Jan)Boccia SCancer Epidemiol Biomarkers Prev
24105756Advances in cancer epidemiology in Japan. (2014 Feb 15)Tanaka HInt J Cancer
17590986Acetaldehyde, polymorphisms and the cardiovascular system. (2007)Yin SJNovartis Found Symp
17590988Interrelationship between alcohol, smoking, acetaldehyde and cancer. (2007)Salaspuro MNovartis Found Symp
26230553[Alcohol consumption patterns and genotypes determining alcohol tolerance in Chilean university students]. (2015 Jun)Silva CPRev Med Chil
15629893Complex I regulates mutant mitochondrial aldehyde dehydrogenase activity and voluntary ethanol consumption in rats. (2005 Jan)Quintanilla MEFASEB J
24797321Effect of the allelic variant of alcohol dehydrogenase ADH1B*2 on ethanol metabolism. (2014 Jun)Kang GAlcohol Clin Exp Res
7726757[Association between alcoholics and the genotypes of ALDH2, ADH2, ADH3 as well as P-4502E1]. (1995 Feb)Nakamura KArukoru Kenkyuto Yakubutsu Ison
16269918Mean corpuscular volume, alcohol flushing, and the predicted risk of squamous cell carcinoma of the esophagus in cancer-free Japanese men. (2005 Oct)Yokoyama AAlcohol Clin Exp Res
18616675Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. (2008 Sep)Yokoyama AAlcohol Clin Exp Res
25759460East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome. (2015 May 12)Mizuno YCirculation
8727242Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese. (1996 May)Higuchi SAlcohol Clin Exp Res
28384229Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. (2017)Yokoyama APLoS One
19348159Use of acetaldehyde and methanol as markers of alcohol abuse and their measurement. (2009 Feb)Tominaga YNihon Arukoru Yakubutsu Igakkai Zasshi
19164089Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. (2009 Jan)Peng GSHum Genomics
20731752Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK. (2011 Aug)Ge WJ Cell Mol Med
9224501Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic liver disease. (1995)Crabb DWProg Liver Dis
22320931Interactions of alcohol and tobacco in gastrointestinal cancer. (2012 Mar)Salaspuro MJ Gastroenterol Hepatol
21270382Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (2011 Apr)Baik IAm J Clin Nutr
19456322Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. (2009 May)Li HAnn Hum Genet
26284938Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men. (2015)Yokoyama APLoS One
16309369Rapid, accurate genotyping of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 based on the use of denaturing HPLC. (2005)Li LClin Chem Lab Med
9066994Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines. (1997 Mar 15)Chen WJBiol Psychiatry
1492799[ALDH phenotype in eating disorders with and without alcoholism]. (1992 Dec)Suzuki KArukoru Kenkyuto Yakubutsu Ison
12884000Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. (2003 Sep)Mulligan CJHum Genet
20598484Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 *7B genotypes in Turkish population. (2010 Aug)Kayaalti ZAlcohol
1733836Distribution of ADH2 and ALDH2 genotypes in different populations. (1992 Jan)Goedde HWHum Genet
9195888Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion. (1997 May 15)Steinmetz CGStructure
28098394Review: Use of Asian samples in genetic research of alcohol use disorders: Genetic variation of alcohol metabolizing enzymes and the effects of acetaldehyde. (2017 Aug)Matsushita SAm J Addict
23712313Genetics and alcoholism. (2013 Aug)Edenberg HJNat Rev Gastroenterol Hepatol
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample. (2014 Mar)Quillen EEAm J Med Genet B Neuropsychiatr Genet
11401907Individual differences in urinary cotinine levels in Japanese smokers: relation to genetic polymorphism of drug-metabolizing enzymes. (2001 Jun)Yang MCancer Epidemiol Biomarkers Prev
15991278Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (2005 Jul 7)Nan HMWorld J Gastroenterol
12705718Polymorphisms for vinyl chloride metabolism in French vinyl chloride workers. (2003)Li YInt J Occup Med Environ Health
14506613Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome. (2003 Sep)Murata CMetabolism
23969552Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes. (2014 Jan-Feb)Yokoyama AAlcohol Alcohol
20166940Primate-accelerated evolutionary genes: novel routes to drug discovery in psychiatric disorders. (2010)Moalic JMCurr Med Chem
8135667[Relationship between alcoholism and genotypes of acetaldehyde-metabolizing enzymes]. (1994 Feb)Iwahashi KArukoru Kenkyuto Yakubutsu Ison
23504072Association of VMAT2 gene polymorphisms with alcohol dependence. (2013 Aug)Fehr CJ Neural Transm (Vienna)
14691070Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. (2004 Jan-Feb)Miyasaka KAlcohol Alcohol
8689400Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. (1996 Feb)Stewart MJJ Investig Med
14568296Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers. (2003 Nov 10)Ishikawa HMutat Res
12211622Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem drinking behavior in middle-aged Japanese men. (2002 Jul)Sun FBehav Genet
11545539ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. (2001 Mar)Shea SHBehav Genet
12519453Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes and male alcohol use disorders in Khon Kaen, north-east Thailand. (2003 Feb)Osaka RPsychiatry Clin Neurosci
9838066Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers. (1998 Dec 3)Wong RHMutat Res
21070510Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not co-morbid with alcoholism. (2012 Sep)Lu RBAddict Biol
28540979Alcohol Consumption, Aldehyde Dehydrogenase 2 Gene Polymorphisms, and Cardiovascular Health in Korea. (2017 Jul)Shin MJYonsei Med J
12759156Aldehyde dehydrogenase 2 genotypes, alcohol flushing symptoms and drinking patterns in Thai men. (2003 May 1)Assanangkornchai SPsychiatry Res
9118563Genetic markers of alcohol abuse. (1997 Jan 17)Ferguson RAClin Chim Acta
10470282Genotype difference of aldehyde dehydrogenase 2 gene in alcohol drinkers influences the incidence of Japanese colorectal cancer patients. (1999 Jul)Murata MJpn J Cancer Res
19584771Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. (2009 Aug)Chen YCPharmacogenet Genomics
29779728Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease. (2018 Mar 20)Chang BAm J Med Sci
16685648Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (2006 Jun)Luo XAm J Hum Genet
27742538Targeting acetaldehyde dehydrogenase 2 (ALDH2) in heart failure-Recent insights and perspectives. (2017 Aug)Pang JBiochim Biophys Acta
27404720Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat. (2016 Jul 12)Sapag AMol Ther Nucleic Acids
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