Gene: UNC5B

219699
UNC5H2|p53RDL1
unc-5 netrin receptor B
protein-coding
10q22.1
Ensembl:ENSG00000107731 MIM:607870 Vega:OTTHUMG00000018422 UniprotKB:Q8IZJ1
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.712e-1 (AD)  5.168e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12766963chr10:71236477 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYO9B0.812
ARAP10.812
DNM20.805
TTC7A0.8
PIK3C2B0.794
NPC10.783
CRTC30.776
ATP11A0.773
MAP3K110.772
RFFL0.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.443
OR4F29-0.415
OR1E1-0.221
HMHB1-0.194
BRDT-0.189
HDC-0.189
SPANXA2-0.184
ZNF705B-0.18
PNMT-0.179
LHX9-0.174

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of UNC5B mRNA"23146750
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of UNC5B mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of UNC5B mRNA"23146750
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of UNC5B mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5B mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of UNC5B mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of UNC5B mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of UNC5B mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UNC5B mRNA23630614
D000447AldehydesAldehydes results in increased expression of UNC5B mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UNC5B mRNA16483693
D001151ArsenicArsenic affects the methylation of UNC5B gene25304211
D001280AtrazineAtrazine results in increased expression of UNC5B mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of UNC5B mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of UNC5B mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UNC5B mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of UNC5B mRNA21569818
D004958EstradiolEstradiol results in decreased expression of UNC5B mRNA19484750
C006780bisphenol Abisphenol A affects the expression of UNC5B mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of UNC5B mRNA23146750
C006780bisphenol Abisphenol A results in increased expression of UNC5B mRNA29275510
C006780bisphenol Abisphenol A affects the expression of UNC5B mRNA25181051
C006780bisphenol A[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of UNC5B mRNA25607892
C006780bisphenol Abisphenol A results in increased methylation of UNC5B gene28505145
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of UNC5B mRNA22079614
C038091butylparaben[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of UNC5B mRNA25607892
C018475butyraldehydebutyraldehyde results in increased expression of UNC5B mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of UNC5B mRNA25979313
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of UNC5B mRNA18636392
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UNC5B mRNA20938992
D002995Clofibric AcidClofibric Acid affects the expression of UNC5B mRNA17602206
D019327Copper SulfateCopper Sulfate results in increased expression of UNC5B mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of UNC5B mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of UNC5B mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of UNC5B mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UNC5B mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of UNC5B mRNA25047013
D003993Dibutyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA25607892
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of UNC5B mRNA28962523
D003633Dichlorodiphenyl Dichloroethylene[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA25607892
D004026DieldrinDieldrin affects the expression of UNC5B mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of UNC5B mRNA28085963
D004051Diethylhexyl Phthalate[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA25607892
C118739entinostatentinostat results in increased expression of UNC5B mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5B mRNA"27188386
C038939enzacamene[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of UNC5B mRNA25607892
C109476epoxiconazole[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA25607892
D000431EthanolEthanol results in increased expression of UNC5B mRNA28986285
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UNC5B mRNA17942748
D005472FluorouracilFluorouracil affects the expression of UNC5B mRNA16584549
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UNC5B mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of UNC5B mRNA27664576
C039281furanfuran results in increased expression of UNC5B mRNA25539665
D017313FenretinideFenretinide results in increased expression of UNC5B mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of UNC5B mRNA20044591
C016517indole-3-carbinolindole-3-carbinol affects the expression of UNC5B mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of UNC5B mRNA27432991
D008044Linuron[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA25607892
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UNC5B mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of UNC5B mRNA26272509
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UNC5B mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of UNC5B mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of UNC5B mRNA24810058
C500085muraglitazarmuraglitazar results in increased expression of UNC5B mRNA21515302
C028007nickel monoxidenickel monoxide results in increased expression of UNC5B mRNA19167457
D009538NicotineNicotine results in increased expression of UNC5B mRNA23825647
C118580octylmethoxycinnamate[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben] results in decreased expression of UNC5B mRNA25607892
D009966OrphenadrineOrphenadrine affects the expression of UNC5B mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of UNC5B mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of UNC5B mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of UNC5B mRNA18636392
D010126OzoneOzone results in decreased expression of UNC5B mRNA16330353
C046012pentanalpentanal results in increased expression of UNC5B mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of UNC5B mRNA19162173
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of UNC5B mRNA26678675
D010634PhenobarbitalPhenobarbital affects the expression of UNC5B mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of UNC5B mRNA19084549
C006253pirinixic acidpirinixic acid results in increased expression of UNC5B mRNA18301758|2381119
D010938Plant OilsPlant Oils results in increased expression of UNC5B mRNA23370395
C045362prochloraz[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA25607892
C035988procymidone[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA25607892
C005556propionaldehydepropionaldehyde results in increased expression of UNC5B mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of UNC5B mRNA24780913
D015474IsotretinoinIsotretinoin results in decreased expression of UNC5B mRNA20436886
C089730rosiglitazonerosiglitazone results in increased expression of UNC5B mRNA21515302
D012643SeleniumSelenium results in increased expression of UNC5B mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of UNC5B mRNA25351596
D012906SmokeSmoke results in decreased expression of UNC5B mRNA21095227
D018038Sodium SeleniteSodium Selenite results in increased expression of UNC5B mRNA24383545
C501413tesaglitazartesaglitazar results in increased expression of UNC5B mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UNC5B mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UNC5B mRNA17942748
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of UNC5B mRNA25975270
D013853ThioacetamideThioacetamide results in increased expression of UNC5B mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of UNC5B mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of UNC5B mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of UNC5B mRNA25729387
D019772TopotecanTopotecan results in increased expression of UNC5B mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased expression of UNC5B mRNA25549359
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of UNC5B mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of UNC5B mRNA28973697
C057693troglitazonetroglitazone results in increased expression of UNC5B mRNA21515302
D014520UrethaneUrethane results in increased expression of UNC5B mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of UNC5B mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of UNC5B mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of UNC5B gene25560391
C025643vinclozolin[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of UNC5B mRNA25607892
C025643vinclozolinvinclozolin affects the expression of UNC5B mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of UNC5B mRNA18042343
C025643vinclozolinvinclozolin results in increased expression of UNC5B mRNA20566332
C025643vinclozolinvinclozolin results in increased methylation of UNC5B promoter22570695
C029297vinylidene chloridevinylidene chloride results in increased expression of UNC5B mRNA26682919
C016837zinc chloridezinc chloride results in increased expression of UNC5B mRNA18947441
D019287Zinc SulfateZinc Sulfate results in increased expression of UNC5B mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005042netrin receptor activity-IEA-  
GO:0005515protein binding-IPI18469807  26235030  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IMP18469807  
GO:0033564anterior/posterior axon guidance-IEA-  
GO:0038007netrin-activated signaling pathway-IEA-  
GO:0043524negative regulation of neuron apoptotic process-IMP18469807  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IMP18469807  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0045121membrane raft-IEA-  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-373752Netrin-1 signalingIEA
R-HSA-418886Netrin mediated repulsion signalsIEA
R-HSA-418889Ligand-independent caspase activation via DCCIEA
R-HSA-422475Axon guidanceIEA
R-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathwayIEA
R-HSA-5357801Programmed Cell DeathIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal