Gene: DOK6

220164
DOK5L|HsT3226
docking protein 6
protein-coding
18q22.2
Ensembl:ENSG00000206052 MIM:611402 Vega:OTTHUMG00000178688 UniprotKB:Q6PKX4
NC_000018.10
SNP Mapped
2   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.161e-1 (AD)  8.041e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7227328chr18:69822648 (GRCh38.p7)G>A / G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs11151527chr18:69679897 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP20.919
FGF130.907
PITPNM30.906
HPCAL40.892
DLG20.888
C1orf210.88
IDS0.877
ATXN10.877
MMP240.877
SGTB0.874

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.529
FLT3LG-0.512
CDA-0.509
AGTRAP-0.502
ATOH8-0.497
A4GALT-0.495
TGIF1-0.494
PLEKHF1-0.478
ROM1-0.477
TIMP1-0.474

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DOK6 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of DOK6 mRNA"21394737
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DOK6 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DOK6 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DOK6 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DOK6 mRNA"25510870
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOK6 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOK6 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of DOK6 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of DOK6 mRNA21641981|2210060
D016604Aflatoxin B1DOK6 gene SNP affects the susceptibility to Aflatoxin B125622337
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of DOK6 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DOK6 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DOK6 mRNA"26238291
C006780bisphenol Abisphenol A affects the expression of DOK6 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of DOK6 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of DOK6 mRNA29097150
D019327Copper SulfateCopper Sulfate results in decreased expression of DOK6 mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of DOK6 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DOK6 mRNA25562108
C118739entinostatentinostat results in decreased expression of DOK6 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DOK6 mRNA29097150
D007213IndomethacinIndomethacin results in increased expression of DOK6 mRNA28201806
C051890irinotecanirinotecan results in decreased expression of DOK6 mRNA20185912
D007854LeadLead affects the expression of DOK6 mRNA28903495
C045463leflunomideleflunomide results in increased expression of DOK6 mRNA28988120
D008727MethotrexateMethotrexate results in increased expression of DOK6 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DOK6 mRNA26011545
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of DOK6 mRNA"25510870
D011441PropylthiouracilPropylthiouracil results in increased expression of DOK6 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of DOK6 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of DOK6 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DOK6 mRNA20106945|2163298
D014635Valproic AcidValproic Acid affects the expression of DOK6 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DOK6 gene29154799
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DOK6 mRNA"27188386
C111237vorinostatvorinostat results in decreased expression of DOK6 mRNA27188386
C111237vorinostatvorinostat results in increased expression of DOK6 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16273093  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0007411axon guidance-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-422475Axon guidanceTAS
R-HSA-8853659RET signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal