Gene: FDXR

2232
ADXR|ANOA
ferredoxin reductase
protein-coding
17q25.1
Ensembl:ENSG00000161513 MIM:103270 Vega:OTTHUMG00000179026 UniprotKB:P22570
NC_000017.11
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.401e-2 (AD)  7.311e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs690307chr17:74863587 (GRCh38.p7)A>C / A>Talcohol dependenceSNV(Single Nucleotide Variation)
rs690371chr17:74862956 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YIF1A0.735
RNH10.727
COMT0.725
SLC25A10.722
SLC27A10.713
RFXANK0.713
H2AFX0.709
NME30.707
APBA30.707
RBCK10.706

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.459
OR4F29-0.436
FER1L6-0.392
ZC3H11B-0.36
GADL1-0.327
OR52M1-0.325
HMCN1-0.325
BMP5-0.323
MXRA5-0.316
DNASE1L3-0.31

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04678311,12-epoxy-5,8,14-eicosatrienoic acid"[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased abundance of 11,12-epoxy-5,8,14-eicosatrienoic acid"25160618
C04678214,15-epoxy-5,8,11-eicosatrienoic acid"[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid"25160618
C05598720-hydroxy-5,8,11,14-eicosatetraenoic acid"[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased abundance of 20-hydroxy-5,8,11,14-eicosatetraenoic acid"25160618
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of FDXR mRNA]"19414516
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of FDXR mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of FDXR mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of FDXR mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of FDXR mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FDXR mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of FDXR mRNA"19561079
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of FDXR mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FDXR mRNA"27188386
C0507158,9-epoxyeicosatrienoic acid"[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased abundance of 8,9-epoxyeicosatrienoic acid"25160618
D000082AcetaminophenAcetaminophen results in increased expression of FDXR mRNA22230336|2570463
D000082AcetaminophenAcetaminophen affects the expression of FDXR mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of FDXR protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FDXR mRNA21632981|2164198
D016604Aflatoxin B1TP53 protein affects the reaction [Aflatoxin B1 results in increased expression of FDXR mRNA]22100608
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of FDXR protein26072098
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FDXR mRNA16483693
D016718Arachidonic Acid[CYP2C8 protein modified form co-treated with FDX1 protein co-treated with FDXR protein] results in increased metabolism of Arachidonic Acid25160618
D001151ArsenicArsenic affects the methylation of FDXR gene25304211
D001205Ascorbic AcidAscorbic Acid results in increased expression of FDXR mRNA15372504
D001280AtrazineAtrazine results in increased expression of FDXR mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FDXR mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FDXR mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of FDXR mRNA"20382639|2623829
C006780bisphenol Abisphenol A results in increased expression of FDXR mRNA29275510
C006780bisphenol Abisphenol A results in decreased methylation of FDXR promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of FDXR mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of FDXR protein28903499
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FDXR protein24740604
D0151248-Bromo Cyclic Adenosine Monophosphate"Hydrocarbons, Chlorinated inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FDXR protein]"24740604
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of FDXR mRNA12414654|2750901
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FDXR protein24527689
D002166CamptothecinCamptothecin results in increased expression of FDXR mRNA17374387
D002220CarbamazepineCarbamazepine affects the expression of FDXR mRNA25979313
D002994ClofibrateClofibrate results in decreased expression of FDXR mRNA23811191
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of FDXR mRNA18078969|2305219
C018021cobaltous chloridecobaltous chloride results in increased expression of FDXR mRNA19376846
D003078ColchicineColchicine results in decreased expression of FDXR mRNA24211769
D016572CyclosporineCyclosporine results in decreased expression of FDXR mRNA20106945|2163298
D003630DaunorubicinDaunorubicin results in increased expression of FDXR mRNA17374387
D003703DemecolcineDemecolcine results in increased expression of FDXR mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FDXR mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FDXR mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of FDXR mRNA17379624|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of FDXR mRNA27392435
D002945CisplatinCisplatin results in increased expression of FDXR mRNA19561079|2153299
D002945Cisplatin[Piroxicam co-treated with Cisplatin] results in decreased expression of FDXR mRNA21858171
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of FDXR mRNA18313992
D004317DoxorubicinDoxorubicin results in increased expression of FDXR mRNA15205334
C118739entinostatentinostat results in increased expression of FDXR mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FDXR mRNA"27188386
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FDXR mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FDXR mRNA12655037|1755790
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of FDXR mRNA23649840
D005047EtoposideEtoposide results in increased expression of FDXR mRNA17374387
D005419FlavonoidsFlavonoids results in increased expression of FDXR mRNA18035473
D005472FluorouracilFluorouracil results in increased expression of FDXR mRNA15205334|1655759
D005472FluorouracilFluorouracil results in increased expression of FDXR mRNA alternative form22966307
D005472FluorouracilFluorouracil results in increased expression of FDXR protein14665630|2296630
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of FDXR mRNA]15016801
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of FDXR mRNA]17982676|2296630
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of FDXR protein]22966307
D005485FlutamideFlutamide results in increased expression of FDXR mRNA19299419
D005557FormaldehydeFormaldehyde results in increased expression of FDXR mRNA23649840
D005897GlafenineGlafenine results in decreased expression of FDXR mRNA24136188
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FDXR protein]"24740604
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FDXR protein18951874
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of FDXR mRNA12414654
C013038hydroxyhydroquinonehydroxyhydroquinone results in increased expression of FDXR mRNA17572062
D007213IndomethacinIndomethacin results in increased expression of FDXR mRNA18299717
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of FDXR mRNA27392435
C410337K 7174K 7174 results in decreased expression of FDXR mRNA24086573
D008748MethylcholanthreneMethylcholanthrene results in increased expression of FDXR mRNA22100608
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FDXR mRNA22100608|2364984
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of FDXR mRNA22776087
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of FDXR mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FDXR mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of FDXR mRNA15674844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FDXR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FDXR mRNA"25620056
D010126OzoneOzone results in decreased expression of FDXR mRNA28623178
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of FDXR mRNA17097637
D010795Phthalic AcidsPhthalic Acids results in decreased expression of FDXR mRNA15728792|2106145
C121565pifithrinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FDXR mRNA]20064835
D010894Piroxicam[Piroxicam co-treated with Cisplatin] results in decreased expression of FDXR mRNA21858171
D059808PolyphenolsPolyphenols results in decreased expression of FDXR mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of FDXR protein23718831
C005556propionaldehydepropionaldehyde results in increased expression of FDXR mRNA26079696
D011794QuercetinQuercetin results in increased expression of FDXR mRNA21632981
C059514resveratrolresveratrol results in increased expression of FDXR mRNA25888808
D012969Sodium FluorideSodium Fluoride results in increased expression of FDXR mRNA21340527
D018038Sodium SeleniteSodium Selenite results in increased expression of FDXR mRNA24383545
D013749Tetrachlorodibenzodioxinpifithrin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FDXR mRNA]20064835
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FDXR mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FDXR mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FDXR mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of FDXR mRNA28973375
D019284ThapsigarginThapsigargin results in increased expression of FDXR mRNA22378314
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of FDXR protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FDXR mRNA28065790
D014118Toxins, Biological"Toxins, Biological affects the expression of FDXR mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in increased methylation of FDXR gene27618143
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of FDXR mRNA18078969|2305219
D014415TunicamycinTunicamycin results in increased expression of FDXR mRNA22378314
D014520UrethaneUrethane results in decreased expression of FDXR mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of FDXR gene29154799
C025643vinclozolinvinclozolin results in increased expression of FDXR mRNA22570695
D000225AdenineAdenine results in decreased expression of FDXR mRNA24211769
D024483Vitamin K 3Vitamin K 3 affects the expression of FDXR mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in increased expression of FDXR mRNA12414654
C111237vorinostatvorinostat results in increased expression of FDXR mRNA27188386
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of FDXR mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004324ferredoxin-NADP+ reductase activity-TAS2845396  
GO:0015039NADPH-adrenodoxin reductase activity-IBA21873635  
GO:0016491oxidoreductase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006091generation of precursor metabolites and energy-TAS2845396  
GO:0006694steroid biosynthetic process-TAS1863359  
GO:0006700C21-steroid hormone biosynthetic process-TAS-  
GO:0006744ubiquinone biosynthetic process-IBA21873635  
GO:0008203cholesterol metabolic process-IEA-  
GO:0016125sterol metabolic process-TAS-  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005743mitochondrial inner membrane-IEA-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1362409Mitochondrial iron-sulfur cluster biogenesisTAS
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-196071Metabolism of steroid hormonesTAS
R-HSA-196108Pregnenolone biosynthesisTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211976Endogenous sterolsTAS
R-HSA-2395516Electron transport from NADPH to FerredoxinTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5579026Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)TAS
R-HSA-5579029Metabolic disorders of biological oxidation enzymesTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-8957322Metabolism of steroidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23144912DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood. (2012)Budworth HPLoS One
28191342Dose-Response Curves of the FDXR and RAD51 Genes with 6 and 18 MV Beam Energies in Human Peripheral Blood Lymphocytes. (2016 Nov)Saberi AIran Red Crescent Med J