Gene: FER

2241
PPP1R74|TYK3|p94-Fer
FER tyrosine kinase
protein-coding
5q21.3
Ensembl:ENSG00000151422 MIM:176942 Vega:OTTHUMG00000128751 UniprotKB:P16591
NG_011445.2
PubMed|SNP Mapped
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.528e-1 (AD)  9.436e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4365877chr5:109188915 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASXL20.889
BTBD70.872
QSER10.863
MED130.856
PKN20.854
ARID20.852
YIPF60.843
SBF20.838
CNOT60.836
LRRC580.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.485
OR4F29-0.462
NPW-0.288
PHLDA2-0.283
PRSS56-0.268
LRRC26-0.257
MUC12-0.257
TGM3-0.24
TNFRSF18-0.235
CRH-0.234

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FER mRNA19933214
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FER mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FER gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of FER mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FER mRNA16483693
D001151ArsenicArsenic affects the methylation of FER gene25304211
D001241AspirinAspirin results in decreased expression of FER mRNA15456535
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of FER mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of FER mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FER mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of FER mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FER mRNA21715664
C006780bisphenol Abisphenol A results in decreased expression of FER mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FER gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of FER mRNA21457566
D002220CarbamazepineCarbamazepine affects the expression of FER mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of FER mRNA17484886
D016572CyclosporineCyclosporine results in increased expression of FER mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FER mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of FER mRNA27392435
D002945CisplatinCisplatin results in decreased expression of FER mRNA27392435
D004008DiclofenacDiclofenac affects the expression of FER mRNA24752500
C000944dicrotophosdicrotophos results in decreased expression of FER mRNA28302478
D004221DisulfiramDisulfiram results in decreased expression of FER mRNA20530235
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FER mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FER mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FER mRNA17942748
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of FER mRNA27392435
C544151jinfukangjinfukang results in decreased expression of FER mRNA27392435
D007854LeadLead affects the splicing of FER mRNA28903495
D008727MethotrexateFER protein affects the susceptibility to Methotrexate16217747
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FER mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of FER mRNA23649840
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FER mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of FER mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FER mRNA"25554681
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FER mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FER mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of FER mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FER mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of FER mRNA22079256
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FER mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FER mRNA17942748
D013849ThimerosalThimerosal results in increased expression of FER mRNA27188386
D013893ThiramThiram results in decreased expression of FER mRNA20530235
D014241TrichloroethyleneTrichloroethylene results in increased methylation of FER gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of FER mRNA26272509
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FER mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of FER mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FER mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of FER gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FER mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of FER gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FER mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004713protein tyrosine kinase activity-TAS2725517  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IBA21873635  
GO:0004715non-membrane spanning protein tyrosine kinase activity-IDA12972546  19738202  
GO:0005102signaling receptor binding-IBA21873635  
GO:0005154epidermal growth factor receptor binding-IDA21518868  
GO:0005515protein binding-IPI15226396  25036637  
GO:0005524ATP binding-IEA-  
GO:0008157protein phosphatase 1 binding-IEA-  
GO:0008289lipid binding-IDA19738202  
GO ID GO Term Qualifier Evidence PubMed
GO:0000226microtubule cytoskeleton organization-IMP12972546  
GO:0000278mitotic cell cycle-IMP22223638  
GO:0001932regulation of protein phosphorylation-ISS-  
GO:0006468protein phosphorylation-TAS2725517  
GO:0006935chemotaxis-IBA21873635  
GO:0007155cell adhesion-IBA21873635  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-IBA21873635  
GO:0007260tyrosine phosphorylation of STAT protein-IDA19147545  
GO:0008283cell proliferation-IMP22223638  
GO:0008284positive regulation of cell proliferation-IMP25540073  
GO:0008284positive regulation of cell proliferation-TAS20111072  
GO:0010591regulation of lamellipodium assembly-IDA19738202  
GO:0010762regulation of fibroblast migration-IEA-  
GO:0016477cell migration-IBA21873635  
GO:0018108peptidyl-tyrosine phosphorylation-IDA12972546  19738202  
GO:0019221cytokine-mediated signaling pathway-IMP9722593  
GO:0030154cell differentiation-IBA21873635  
GO:0030335positive regulation of cell migration-IMP19738202  
GO:0030838positive regulation of actin filament polymerization-IMP19738202  
GO:0031532actin cytoskeleton reorganization-ISS-  
GO:0032496response to lipopolysaccharide-ISS-  
GO:0032869cellular response to insulin stimulus-ISS-  
GO:0033007negative regulation of mast cell activation involved in immune response-ISS-  
GO:0034446substrate adhesion-dependent cell spreading-ISS-  
GO:0034614cellular response to reactive oxygen species-ISS-  
GO:0035426extracellular matrix-cell signaling-ISS-  
GO:0035556intracellular signal transduction-TAS2209086  
GO:0036006cellular response to macrophage colony-stimulating factor stimulus-IMP9722593  
GO:0036119response to platelet-derived growth factor-ISS-  
GO:0038028insulin receptor signaling pathway via phosphatidylinositol 3-kinase-ISS-  
GO:0038083peptidyl-tyrosine autophosphorylation-IBA21873635  
GO:0038095Fc-epsilon receptor signaling pathway-IBA21873635  
GO:0038095Fc-epsilon receptor signaling pathway-ISS-  
GO:0038109Kit signaling pathway-ISS-  
GO:0042058regulation of epidermal growth factor receptor signaling pathway-IMP21518868  
GO:0042127regulation of cell proliferation-IBA21873635  
GO:0043304regulation of mast cell degranulation-IBA21873635  
GO:0044331cell-cell adhesion mediated by cadherin-ISS-  
GO:0045087innate immune response-IBA21873635  
GO:0046777protein autophosphorylation-IDA7623846  
GO:0048008platelet-derived growth factor receptor signaling pathway-ISS-  
GO:0048008platelet-derived growth factor receptor signaling pathway-TAS11994747  
GO:0050904diapedesis-ISS-  
GO:0051092positive regulation of NF-kappaB transcription factor activity-IMP21518868  
GO:0070102interleukin-6-mediated signaling pathway-IMP19147545  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatincolocalizes_withIDA1990274  
GO:0005634nucleus-IDA19147545  
GO:0005737cytoplasm-IDA1990274  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005938cell cortex-IEA-  
GO:0015629actin cytoskeletoncolocalizes_withIDA19738202  
GO:0015630microtubule cytoskeletoncolocalizes_withIDA12972546  
GO:0030027lamellipodiumcolocalizes_withIDA19738202  
GO:0030054cell junctioncolocalizes_withIDA12972546  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IBA21873635  
GO:0031234extrinsic component of cytoplasmic side of plasma membrane-IDA19738202  
KEGG ID KEGG Term
hsa04520Adherens junction
Reactome ID Reactome Term Evidence
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-162582Signal TransductionTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14578319Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography. (2003 Nov)Frohlich JClin Chem
28913946Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met. (2017 Nov)Carra GHum Psychopharmacol
23573306FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer. (2013)Kawakami MInt J Clin Exp Pathol