Gene info: ID 2241

Gene: FER

GENE ID: 2241

Synonyms: PPP1R74|TYK3|p94-Fer

Description: FER tyrosine kinase

Gene type: protein-coding

Location: 5q21.3

dbXrefs: Ensembl:ENSG00000151422 MIM:176942 Vega:OTTHUMG00000128751 UniprotKB:P16591

RefSeq: NG_011445.2

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.528e-1 (AD) 9.436e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4365877	chr5:109188915 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ASXL2	0.889
BTBD7	0.872
QSER1	0.863
MED13	0.856
PKN2	0.854
ARID2	0.852
YIPF6	0.843
SBF2	0.838
CNOT6	0.836
LRRC58	0.836

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.485
OR4F29	-0.462
NPW	-0.288
PHLDA2	-0.283
PRSS56	-0.268
LRRC26	-0.257
MUC12	-0.257
TGM3	-0.24
TNFRSF18	-0.235
CRH	-0.234

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FER mRNA	19933214
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of FER mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of FER gene	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of FER mRNA	19770486
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of FER mRNA	16483693
D001151	Arsenic	Arsenic affects the methylation of FER gene	25304211
D001241	Aspirin	Aspirin results in decreased expression of FER mRNA	15456535
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of FER mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of FER mRNA	21714911
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FER mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of FER mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FER mRNA	21715664
C006780	bisphenol A	bisphenol A results in decreased expression of FER mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of FER gene	28505145
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of FER mRNA	21457566
D002220	Carbamazepine	Carbamazepine affects the expression of FER mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of FER mRNA	17484886
D016572	Cyclosporine	Cyclosporine results in increased expression of FER mRNA	25562108
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of FER mRNA]	27941970
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of FER mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of FER mRNA	27392435
D004008	Diclofenac	Diclofenac affects the expression of FER mRNA	24752500
C000944	dicrotophos	dicrotophos results in decreased expression of FER mRNA	28302478
D004221	Disulfiram	Disulfiram results in decreased expression of FER mRNA	20530235
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FER mRNA	22079256
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of FER mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FER mRNA	17942748
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of FER mRNA	27392435
C544151	jinfukang	jinfukang results in decreased expression of FER mRNA	27392435
D007854	Lead	Lead affects the splicing of FER mRNA	28903495
D008727	Methotrexate	FER protein affects the susceptibility to Methotrexate	16217747
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of FER mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of FER mRNA	23649840
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of FER mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of FER mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of FER mRNA"	25554681
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of FER mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of FER mRNA	19710929
D010936	Plant Extracts	Plant Extracts results in increased expression of FER mRNA	23557933
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of FER mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of FER mRNA	22079256
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FER mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FER mRNA	17942748
D013849	Thimerosal	Thimerosal results in increased expression of FER mRNA	27188386
D013893	Thiram	Thiram results in decreased expression of FER mRNA	20530235
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of FER gene	27618143
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of FER mRNA	26272509
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of FER mRNA"	26179874
C057693	troglitazone	troglitazone results in decreased expression of FER mRNA	28973697
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FER mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of FER mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of FER gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of FER mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of FER gene	25560391
C025643	vinclozolin	vinclozolin results in decreased expression of FER mRNA	22570695

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004713	protein tyrosine kinase activity	-	TAS	2725517
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IBA	21873635
GO:0004715	non-membrane spanning protein tyrosine kinase activity	-	IDA	12972546 19738202
GO:0005102	signaling receptor binding	-	IBA	21873635
GO:0005154	epidermal growth factor receptor binding	-	IDA	21518868
GO:0005515	protein binding	-	IPI	15226396 25036637
GO:0005524	ATP binding	-	IEA	-
GO:0008157	protein phosphatase 1 binding	-	IEA	-
GO:0008289	lipid binding	-	IDA	19738202

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000226	microtubule cytoskeleton organization	-	IMP	12972546
GO:0000278	mitotic cell cycle	-	IMP	22223638
GO:0001932	regulation of protein phosphorylation	-	ISS	-
GO:0006468	protein phosphorylation	-	TAS	2725517
GO:0006935	chemotaxis	-	IBA	21873635
GO:0007155	cell adhesion	-	IBA	21873635
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	-	IBA	21873635
GO:0007260	tyrosine phosphorylation of STAT protein	-	IDA	19147545
GO:0008283	cell proliferation	-	IMP	22223638
GO:0008284	positive regulation of cell proliferation	-	IMP	25540073
GO:0008284	positive regulation of cell proliferation	-	TAS	20111072
GO:0010591	regulation of lamellipodium assembly	-	IDA	19738202
GO:0010762	regulation of fibroblast migration	-	IEA	-
GO:0016477	cell migration	-	IBA	21873635
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	12972546 19738202
GO:0019221	cytokine-mediated signaling pathway	-	IMP	9722593
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030335	positive regulation of cell migration	-	IMP	19738202
GO:0030838	positive regulation of actin filament polymerization	-	IMP	19738202
GO:0031532	actin cytoskeleton reorganization	-	ISS	-
GO:0032496	response to lipopolysaccharide	-	ISS	-
GO:0032869	cellular response to insulin stimulus	-	ISS	-
GO:0033007	negative regulation of mast cell activation involved in immune response	-	ISS	-
GO:0034446	substrate adhesion-dependent cell spreading	-	ISS	-
GO:0034614	cellular response to reactive oxygen species	-	ISS	-
GO:0035426	extracellular matrix-cell signaling	-	ISS	-
GO:0035556	intracellular signal transduction	-	TAS	2209086
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	-	IMP	9722593
GO:0036119	response to platelet-derived growth factor	-	ISS	-
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	-	ISS	-
GO:0038083	peptidyl-tyrosine autophosphorylation	-	IBA	21873635
GO:0038095	Fc-epsilon receptor signaling pathway	-	IBA	21873635
GO:0038095	Fc-epsilon receptor signaling pathway	-	ISS	-
GO:0038109	Kit signaling pathway	-	ISS	-
GO:0042058	regulation of epidermal growth factor receptor signaling pathway	-	IMP	21518868
GO:0042127	regulation of cell proliferation	-	IBA	21873635
GO:0043304	regulation of mast cell degranulation	-	IBA	21873635
GO:0044331	cell-cell adhesion mediated by cadherin	-	ISS	-
GO:0045087	innate immune response	-	IBA	21873635
GO:0046777	protein autophosphorylation	-	IDA	7623846
GO:0048008	platelet-derived growth factor receptor signaling pathway	-	ISS	-
GO:0048008	platelet-derived growth factor receptor signaling pathway	-	TAS	11994747
GO:0050904	diapedesis	-	ISS	-
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	IMP	21518868
GO:0070102	interleukin-6-mediated signaling pathway	-	IMP	19147545

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	colocalizes_with	IDA	1990274
GO:0005634	nucleus	-	IDA	19147545
GO:0005737	cytoplasm	-	IDA	1990274
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0005938	cell cortex	-	IEA	-
GO:0015629	actin cytoskeleton	colocalizes_with	IDA	19738202
GO:0015630	microtubule cytoskeleton	colocalizes_with	IDA	12972546
GO:0030027	lamellipodium	colocalizes_with	IDA	19738202
GO:0030054	cell junction	colocalizes_with	IDA	12972546
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IBA	21873635
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	-	IDA	19738202

KEGG ID	KEGG Term
hsa04520	Adherens junction

Reactome ID	Reactome Term	Evidence
R-HSA-1433557	Signaling by SCF-KIT	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
14578319	Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography. (2003 Nov)	Frohlich J	Clin Chem
28913946	Facial emotion recognition in schizophrenia: An exploratory study on the role of comorbid alcohol and substance use disorders and COMT Val158Met. (2017 Nov)	Carra G	Hum Psychopharmacol
23573306	FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer. (2013)	Kawakami M	Int J Clin Exp Pathol