Gene: FGF14

2259
FGF-14|FHF-4|FHF4|SCA27
fibroblast growth factor 14
protein-coding
13q33.1
Ensembl:ENSG00000102466 MIM:601515 Vega:OTTHUMG00000017303 UniprotKB:Q92915
NG_008317.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.739e-2 (AD)  9.412e-3 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7322577chr13:102184424 (GRCh38.p7)T>A / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7324177chr13:101975249 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04561389chr13:103052468FGF148.930e-23Alcohol consumption per day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRB30.971
SCN2A0.965
FGF120.963
FRRS1L0.963
PAK30.962
KCNIP40.961
GABRG20.958
FAXC0.957
MAL20.956
MYT1L0.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.547
HEY2-0.526
RAI14-0.525
SYDE1-0.524
REST-0.52
CNN2-0.518
MYL3-0.511
RUNX3-0.509
CHST14-0.506
FZD10-0.498

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF14 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF14 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF14 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF14 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF14 mRNA"25510870
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN2A protein]"26917740
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole inhibits the reaction [FGF14 protein binds to SCN8A protein]"26917740
C4053544,5,6,7-tetrabromobenzotriazole"4,5,6,7-tetrabromobenzotriazole results in decreased expression of and affects the localization of FGF14 protein"26917740
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF14 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF14 mRNA"27188386
C014949acetylhydrazineacetylhydrazine results in decreased expression of FGF14 mRNA15282401
D020106AcrylamideAcrylamide results in decreased expression of FGF14 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of FGF14 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FGF14 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FGF14 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of FGF14 mRNA26705709
C006780bisphenol Abisphenol A results in decreased expression of FGF14 mRNA25181051
D003471CuprizoneCuprizone results in decreased expression of FGF14 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of FGF14 mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of FGF14 mRNA23640034
D003976DiazinonDiazinon affects the expression of FGF14 mRNA17589599
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of FGF14 mRNA29097150
C039281furanfuran results in decreased expression of FGF14 mRNA25539665
D007657Ketone BodiesKetone Bodies results in decreased expression of FGF14 mRNA16807920
D007854LeadLead affects the expression of FGF14 mRNA28903495
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of FGF14 mRNA12057914
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of FGF14 mRNA"20188158
D009532NickelNickel results in decreased expression of FGF14 mRNA25583101
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of FGF14 mRNA"21673326
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of FGF14 mRNA]"21673326
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of FGF14 mRNA"25510870
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of FGF14 mRNA26705709
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of FGF14 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of FGF14 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of FGF14 mRNA23608068
C402769tipifarnibtipifarnib results in increased expression of FGF14 mRNA16403772
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of FGF14 mRNA18087596
D014212TretinoinTretinoin results in decreased expression of FGF14 protein11241832
D014635Valproic AcidValproic Acid affects the expression of FGF14 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of FGF14 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of FGF14 mRNA28001369
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FGF14 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI26900580  
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS8790420  
GO:0007267cell-cell signaling-TAS8790420  
GO:0007399nervous system development-IEA-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0048167regulation of synaptic plasticity-IEA-  
GO:0060078regulation of postsynaptic membrane potential-IEA-  
GO:1901843positive regulation of high voltage-gated calcium channel activity-IEA-  
GO:1903421regulation of synaptic vesicle recycling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-5576891Cardiac conductionTAS
R-HSA-5576892Phase 0 - rapid depolarisationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal