Gene: LAMB4

22798
-
laminin subunit beta 4
protein-coding
7q31.1
Ensembl:ENSG00000091128 MIM:616380 Vega:OTTHUMG00000154874 UniprotKB:A4D0S4
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.398e-1 (AD)  7.417e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7794978chr7:108124785 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OTOR0.629
CPN20.586
MUC170.579
TAS2R600.559
OR7C20.556
FAM83C0.542
TAAR10.538
IL200.529
UGT2B40.524
HTR3D0.521

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSN1S1-0.227
ZNRF4-0.223
INHA-0.196
TDO2-0.182
BCKDHB-0.173
ALOX12B-0.172
LDHD-0.171
MAGEC3-0.169
GSTZ1-0.168
C5-0.164

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of LAMB4 mRNA"25614096
D001280AtrazineAtrazine results in decreased expression of LAMB4 mRNA23358194
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of LAMB4 mRNA21871943
D008628MercuryMercury results in increased expression of LAMB4 mRNA16823088
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of LAMB4 mRNA26011545

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005604basement membrane-IEA-  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05200Pathways in cancer
hsa05222Small cell lung cancer
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal