Gene: MRAS

22808
M-RAs|R-RAS3|RRAS3
muscle RAS oncogene homolog
protein-coding
3q22.3
Ensembl:ENSG00000158186 MIM:608435 Vega:OTTHUMG00000159888 UniprotKB:O14807
NC_000003.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.842e-1 (AD)  4.482e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1199335chr3:138370982 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAPKAP10.876
TSPAN70.876
CPE0.874
ENO10.865
ABAT0.862
GPM6A0.862
THRA0.856
FAM213A0.855
UNC119B0.855
LDHB0.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.805
OR4F29-0.765
CLEC6A-0.294
GADL1-0.289
FCRL1-0.281
C2orf83-0.28
TFPI2-0.279
TRPV5-0.277
TBX21-0.277
SLC9A4-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of MRAS mRNA23792671
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MRAS mRNA"21703328
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of MRAS mRNA16788091
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [EGF protein results in increased activity of MRAS protein]"11943669
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [sodium arsenite results in increased activity of MRAS protein]"11943669
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [vanadyl sulfate results in increased activity of MRAS protein]"11943669
C0888604-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc Sulfate results in increased activity of MRAS protein]"11943669
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MRAS mRNA"18648102
C0415944-nonylphenol4-nonylphenol results in increased expression of MRAS mRNA19000778
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of MRAS mRNA19000778
D000082AcetaminophenAcetaminophen affects the expression of MRAS mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MRAS gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MRAS mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MRAS mRNA16483693
D001151ArsenicArsenic affects the expression of MRAS mRNA18414638
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MRAS mRNA"17331233
C547126AZM551248AZM551248 results in increased expression of MRAS mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MRAS mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MRAS mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MRAS mRNA19770486
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of MRAS mRNA20660070
D004958EstradiolEstradiol results in increased expression of MRAS mRNA19000778
C006780bisphenol Abisphenol A results in increased expression of MRAS mRNA19000778
C006780bisphenol Abisphenol A results in increased expression of MRAS mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MRAS mRNA22079614
D002220CarbamazepineCarbamazepine affects the expression of MRAS mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MRAS mRNA17805973
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of MRAS mRNA19395590
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of MRAS mRNA23650126
D003042CocaineCocaine affects the expression of MRAS mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of MRAS mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MRAS mRNA21266533
D002945CisplatinCisplatin results in increased expression of MRAS mRNA27392435
D004008DiclofenacDiclofenac affects the expression of MRAS mRNA24752500
D004041Dietary FatsDietary Fats results in increased expression of MRAS mRNA25016146
D004041Dietary FatsDietary Fats results in decreased expression of MRAS mRNA21852083
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MRAS mRNA26464624
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRAS mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MRAS mRNA15212814
D005047EtoposideEtoposide results in decreased expression of MRAS mRNA25270620
C082360fipronilfipronil results in increased expression of MRAS mRNA23962444
D005472FluorouracilFluorouracil affects the expression of MRAS mRNA16584549
C069837fullerene C60fullerene C60 results in decreased expression of MRAS mRNA19167457
C039281furanfuran results in decreased expression of MRAS mRNA26194646
D005947GlucoseGlucose results in increased activity of MRAS protein18569938
D005947Glucosemanumycin inhibits the reaction [Glucose results in increased activity of MRAS protein]18569938
D005947GlucoseSimvastatin inhibits the reaction [Glucose results in increased activity of MRAS protein]18569938
C016517indole-3-carbinolindole-3-carbinol affects the expression of MRAS mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MRAS mRNA26752646
D007649KetamineKetamine results in increased expression of MRAS mRNA20080153
C045463leflunomideleflunomide results in increased expression of MRAS mRNA28988120
D008095Lithocholic AcidLithocholic Acid binds to MRAS protein18641422
C054474manumycinmanumycin inhibits the reaction [Glucose results in increased activity of MRAS protein]18569938
D008731MethoxychlorMethoxychlor affects the expression of MRAS mRNA20829426
D008731MethoxychlorMethoxychlor results in decreased expression of MRAS mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride affects the expression of MRAS protein27012723
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of MRAS mRNA20965277
D009151Mustard GasMustard Gas results in increased expression of MRAS mRNA15674844
D009532NickelNickel results in decreased expression of MRAS mRNA25583101
D009966OrphenadrineOrphenadrine affects the expression of MRAS mRNA23665939
D052638Particulate MatterParticulate Matter results in increased expression of MRAS mRNA17987463
C410127PCB 180PCB 180 affects the expression of MRAS mRNA21703328
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MRAS mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of MRAS mRNA19482888
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of MRAS mRNA21334430
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of MRAS mRNA20660070
D019821SimvastatinSimvastatin inhibits the reaction [Glucose results in increased activity of MRAS protein]18569938
D019821SimvastatinSimvastatin inhibits the reaction [Smoke analog results in increased activity of MRAS protein]19299917
D012906SmokeSimvastatin inhibits the reaction [Smoke analog results in increased activity of MRAS protein]19299917
D012906SmokeSmoke analog results in increased activity of MRAS protein19299917
C017947sodium arsenite"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [sodium arsenite results in increased activity of MRAS protein]"11943669
C017947sodium arseniteMRAS mutant form inhibits the reaction [sodium arsenite results in increased phosphorylation of MAP2K1 protein]11943669
C017947sodium arseniteMRAS mutant form inhibits the reaction [sodium arsenite results in increased phosphorylation of MAP2K2 protein]11943669
C017947sodium arseniteMRAS mutant form inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]11943669
C017947sodium arseniteMRAS mutant form inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]11943669
C017947sodium arsenitesodium arsenite results in increased activity of MRAS protein11943669
D010042OuabainOuabain results in decreased expression of MRAS mRNA28795476
C025462sulindac sulfidesulindac sulfide results in increased expression of MRAS mRNA16184548
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MRAS mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MRAS mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRAS mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MRAS mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MRAS mRNA27913140
C402769tipifarnibtipifarnib results in increased expression of MRAS mRNA16403772
C483909torcetrapibtorcetrapib results in increased expression of MRAS mRNA23228038
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MRAS mRNA"26179874
D014520UrethaneUrethane results in decreased expression of MRAS mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of MRAS gene29154799
C034028vanadyl sulfate"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [vanadyl sulfate results in increased activity of MRAS protein]"11943669
C034028vanadyl sulfateMRAS mutant form inhibits the reaction [vanadyl sulfate results in increased activity of and affects the localization of [RELA protein binds to NFKB1 protein]]11943669
C034028vanadyl sulfateMRAS mutant form inhibits the reaction [vanadyl sulfate results in increased degradation of NFKBIA protein]11943669
C034028vanadyl sulfateMRAS mutant form inhibits the reaction [vanadyl sulfate results in increased phosphorylation of MAP2K1 protein]11943669
C034028vanadyl sulfateMRAS mutant form inhibits the reaction [vanadyl sulfate results in increased phosphorylation of MAP2K2 protein]11943669
C034028vanadyl sulfateMRAS mutant form inhibits the reaction [vanadyl sulfate results in increased phosphorylation of MAPK1 protein]11943669
C034028vanadyl sulfateMRAS mutant form inhibits the reaction [vanadyl sulfate results in increased phosphorylation of MAPK3 protein]11943669
C034028vanadyl sulfatevanadyl sulfate results in increased activity of MRAS protein11943669
D001335Vehicle EmissionsVehicle Emissions results in increased expression of MRAS mRNA17987463
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MRAS gene25560391
D015032ZincZinc results in increased expression of MRAS mRNA15984569
D019287Zinc Sulfate"4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Zinc Sulfate results in increased activity of MRAS protein]"11943669
D019287Zinc SulfateMRAS mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAP2K1 protein]11943669
D019287Zinc SulfateMRAS mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAP2K2 protein]11943669
D019287Zinc SulfateMRAS mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]11943669
D019287Zinc SulfateMRAS mutant form inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]11943669
D019287Zinc SulfateZinc Sulfate results in increased activity of MRAS protein11943669

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IEA-  
GO:0005515protein binding-IPI10446149  25137548  
GO:0005525GTP binding-IEA-  
GO:0030742GTP-dependent protein binding-IPI10934204  
GO ID GO Term Qualifier Evidence PubMed
GO:0007265Ras protein signal transduction-TAS10446149  
GO:0007275multicellular organism development-TAS10446149  
GO:0007517muscle organ development-TAS9395237  
GO:0030036actin cytoskeleton organization-TAS9395237  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IEA-  
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28167353Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants. (2017 Mar)Shahid SUAtherosclerosis
28737528Genetic variants of increased waist circumference in psychosis. (2017 Dec)Hukic DSPsychiatr Genet
27263109A Single-Nucleotide Polymorphism in C12orf43 Region is Associated with the Risk of Coronary Artery Disease in a Pakistani Cohort. (2016 Oct)Shahzadi SBiochem Genet