Gene: ZHX2

22882
AFR1|RAF
zinc fingers and homeoboxes 2
protein-coding
8q24.13
Ensembl:ENSG00000178764 MIM:609185 Vega:OTTHUMG00000165077 UniprotKB:Q9Y6X8
NG_046951.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.297e-1 (AD)  9.735e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4871326chr8:122930907 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs6470120chr8:122868979 (GRCh38.p7)G>Aalcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1orf1980.871
NFIA0.87
FGFR20.868
DDR10.864
QKI0.859
EFHD10.857
MTMR100.856
FBXL70.853
PMP220.851
SGK30.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RTP1-0.571
MCHR1-0.57
PRSS12-0.552
KCNH5-0.551
AGMAT-0.545
FBLN7-0.544
TPBG-0.544
SERTM1-0.543
CNTN5-0.534
MYOZ3-0.532

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ZHX2 mRNA19933214
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ZHX2 mRNA"21346803
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of ZHX2 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ZHX2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ZHX2 protein20106945
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ZHX2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZHX2 mRNA24449571
D001151ArsenicArsenic affects the methylation of ZHX2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZHX2 mRNA20106945|2163298
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ZHX2 mRNA]22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ZHX2 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of ZHX2 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ZHX2 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of ZHX2 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of ZHX2 gene22576693
C006780bisphenol Abisphenol A affects the methylation of ZHX2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ZHX2 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZHX2 gene20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of ZHX2 mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ZHX2 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of ZHX2 mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of ZHX2 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ZHX2 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of ZHX2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of ZHX2 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of ZHX2 mRNA28302478
C118739entinostatentinostat results in increased expression of ZHX2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ZHX2 protein23301498
D005485FlutamideFlutamide results in decreased expression of ZHX2 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZHX2 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of ZHX2 mRNA20655997|2364984
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of ZHX2 mRNA20846436
C069837fullerene C60fullerene C60 results in decreased expression of ZHX2 mRNA19167457
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of ZHX2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZHX2 mRNA23086925|2479639
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ZHX2 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ZHX2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ZHX2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ZHX2 mRNA"20188158
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of ZHX2 mRNA29162477
C028007nickel monoxidenickel monoxide results in decreased expression of ZHX2 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ZHX2 mRNA20971185
D011794QuercetinQuercetin results in decreased expression of ZHX2 mRNA21632981
C059514resveratrolresveratrol results in decreased expression of ZHX2 mRNA25905778
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZHX2 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZHX2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZHX2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZHX2 mRNA21215274
D019284ThapsigarginThapsigargin results in increased expression of ZHX2 mRNA22378314
D013893ThiramThiram results in decreased expression of ZHX2 mRNA20530235
D014212TretinoinTretinoin results in decreased expression of ZHX2 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in decreased expression of ZHX2 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ZHX2 mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZHX2 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of ZHX2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of ZHX2 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ZHX2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ZHX2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of ZHX2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ZHX2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZHX2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of ZHX2 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003677DNA binding-IEA-  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA12741956  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0003714transcription corepressor activity-IDA12741956  
GO:0005515protein binding-IPI12741956  26496610  
GO:0042802identical protein binding-IPI12741956  
GO:0042803protein homodimerization activity-IDA12741956  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IDA12741956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-IDA12741956  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006402mRNA catabolic process-IEA-  
GO:0035019somatic stem cell population maintenance-IEA-  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA12741956  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12741956  17056598  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25746325Genetic association and gene-smoking interaction study of carotid intima-media thickness at five GWAS-indicated genes: the Bogalusa Heart Study. (2015 May 15)Li CGene