Gene: ZNF365

22891
Su48|UAN|ZNF365D
zinc finger protein 365
protein-coding
10q21.2
Ensembl:ENSG00000138311 MIM:607818 Vega:OTTHUMG00000018302 UniprotKB:Q70YC4
NG_021209.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.714e-1 (AD)  8.404e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2138564chr10:62547558 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRG20.958
NELL20.958
NLK0.956
PDP10.955
RBFOX10.955
SH3GL20.954
AMPH0.954
GLS0.954
PAK10.952
ADAM220.951

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.51
CSAG1-0.503
RNF135-0.503
RUNX3-0.482
LRAT-0.479
MYL3-0.478
RHOD-0.475
EVC2-0.471
MDFI-0.471
ARHGEF5-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000447AldehydesAldehydes results in increased expression of ZNF365 mRNA25014914
D001151ArsenicArsenic affects the methylation of ZNF365 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of ZNF365 mRNA"25351596
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ZNF365 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ZNF365 mRNA19619570
C006780bisphenol Abisphenol A affects the expression of ZNF365 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of ZNF365 mRNA26079696
D016572CyclosporineCyclosporine results in increased expression of ZNF365 mRNA27989131
D004397FonofosFonofos results in increased methylation of ZNF365 promoter22847954
C492448ICG 001ICG 001 results in decreased expression of ZNF365 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ZNF365 mRNA25307878
D007854LeadLead affects the expression of ZNF365 mRNA28903495
D010278ParathionParathion results in increased methylation of ZNF365 promoter22847954
C046012pentanalpentanal results in increased expression of ZNF365 mRNA26079696
C005556propionaldehydepropionaldehyde results in increased expression of ZNF365 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ZNF365 mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of ZNF365 gene28589171
C012568terbufosterbufos results in increased methylation of ZNF365 promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ZNF365 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZNF365 mRNA19619570
C012589trichostatin Atrichostatin A results in increased expression of ZNF365 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of ZNF365 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ZNF365 mRNA19101580|2317975
D014638VanadatesVanadates results in increased expression of ZNF365 mRNA22714537
C111237vorinostatvorinostat results in increased expression of ZNF365 mRNA27188386
C088658zoledronic acidzoledronic acid results in decreased expression of ZNF365 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16682949  17389905  23966166  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IMP23776040  
GO:0010569regulation of double-strand break repair via homologous recombination-IMP23966166  
GO:0010977negative regulation of neuron projection development-IDA17389905  
GO:0021687cerebellar molecular layer morphogenesis-ISS-  
GO:0048714positive regulation of oligodendrocyte differentiation-ISS-  
GO:0060997dendritic spine morphogenesis-ISS-  
GO:0110026regulation of DNA strand resection involved in replication fork processing-IMP23966166  
GO:0140059dendrite arborization-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005815microtubule organizing center-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal