Gene: DENND3

22898
-
DENN domain containing 3
protein-coding
8q24.3
Ensembl:ENSG00000105339 MIM:617503 Vega:OTTHUMG00000164775 UniprotKB:A2RUS2
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.027e-1 (AD)  1.613e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs307766chr8:141141614 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MKNK10.832
MAP3K30.821
MAN2C10.816
GTPBP20.811
FNBP40.81
FKBP150.807
ASXL10.805
STAT60.796
WDR910.795
LMBR1L0.792

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.414
OR4F29-0.408
DIAPH3-0.341
LYPD1-0.299
SLC22A6-0.28
KLRC2-0.279
SLC27A6-0.278
HES5-0.268
IRX2-0.265
PLA2G5-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of DENND3 mRNA17562736
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DENND3 mRNA24449571
D001151ArsenicArsenic affects the methylation of DENND3 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DENND3 mRNA21569818|2222880
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DENND3 mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DENND3 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of DENND3 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DENND3 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of DENND3 mRNA15336504
D002922CiguatoxinsCiguatoxins affects the expression of DENND3 mRNA18353800
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DENND3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DENND3 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DENND3 mRNA28628672
D004041Dietary FatsDietary Fats results in increased expression of DENND3 mRNA25016146
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DENND3 mRNA22079256
C069837fullerene C60fullerene C60 results in increased expression of DENND3 mRNA19167457
D017313FenretinideFenretinide results in increased expression of DENND3 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DENND3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DENND3 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DENND3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of DENND3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of DENND3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of DENND3 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DENND3 mRNA23086925
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of DENND3 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DENND3 mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of DENND3 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DENND3 mRNA25729387
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of DENND3 mRNA18593933
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DENND3 mRNA19710929
D010936Plant ExtractsPlant Extracts results in increased expression of DENND3 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DENND3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DENND3 mRNA22079256|2271453
D011374ProgesteroneProgesterone results in increased expression of DENND3 mRNA23018184
D011441PropylthiouracilPropylthiouracil results in increased expression of DENND3 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of DENND3 mRNA25895662
D053260SootSoot results in increased expression of DENND3 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DENND3 mRNA22574217
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of DENND3 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DENND3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of DENND3 mRNA16054129
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DENND3 mRNA29024780
D014520UrethaneUrethane results in decreased expression of DENND3 mRNA28818685
C025643vinclozolinvinclozolin affects the expression of DENND3 mRNA19015723
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of DENND3 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017112Rab guanyl-nucleotide exchange factor activity-IDA20937701  
GO:0017112Rab guanyl-nucleotide exchange factor activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008333endosome to lysosome transport-ISS-  
GO:0044257cellular protein catabolic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8876198RAB GEFs exchange GTP for GDP on RABsTAS
R-HSA-9007101Rab regulation of traffickingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal