Gene: ARSG

22901
-
arylsulfatase G
protein-coding
17q24.2
Ensembl:ENSG00000141337 MIM:610008 Vega:OTTHUMG00000179810 UniprotKB:Q96EG1
NG_032814.2
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.184e-1 (AD)  2.340e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6501422chr17:68393505 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRAPPC110.841
RINT10.833
GON4L0.831
PMS20.83
MED140.825
LMLN0.825
NFATC2IP0.824
CSTF20.817
DOPEY10.816
CEP680.814

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC102A-0.359
OR4F5-0.354
MTRNR2L9-0.342
HEY2-0.341
KLRC2-0.337
MTRNR2L6-0.33
OR4F29-0.329
MDFI-0.327
FOXJ1-0.321
BCL7C-0.32

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of ARSG mRNA"26377693
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARSG mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARSG mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARSG mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARSG mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of ARSG mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ARSG mRNA19770486
D000452AldrinAldrin results in increased expression of ARSG mRNA18579281
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of ARSG mRNA"22863853
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARSG mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARSG mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ARSG mRNA27195522
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ARSG mRNA22300585
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ARSG mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ARSG mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARSG mRNA28628672
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARSG mRNA20938992
D019327Copper SulfateCopper Sulfate results in decreased expression of ARSG mRNA19549813
D019327Copper SulfateCopper Sulfate results in increased expression of ARSG mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of ARSG mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of ARSG mRNA21632981
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ARSG mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARSG mRNA28628672
D004041Dietary FatsDietary Fats affects the expression of ARSG mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of ARSG mRNA18457598
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of ARSG mRNA21852083
D000431EthanolEthanol results in increased expression of ARSG mRNA28986285
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARSG mRNA20938992
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA19695318
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ARSG mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARSG mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARSG mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ARSG mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ARSG mRNA28628672
C544151jinfukangjinfukang results in increased expression of ARSG mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ARSG mRNA23086925
C410337K 7174K 7174 results in decreased expression of ARSG mRNA24086573
C045463leflunomideleflunomide results in increased expression of ARSG mRNA28988120
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ARSG mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ARSG mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ARSG mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ARSG mRNA"25620056
D000073878Palm OilPalm Oil affects the expression of ARSG mRNA19680557
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ARSG mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of ARSG mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of ARSG mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARSG mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ARSG mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of ARSG mRNA17426115
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA19695318
C005556propionaldehydepropionaldehyde results in increased expression of ARSG mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of ARSG mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ARSG mRNA21632981
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of ARSG mRNA21852083
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARSG mRNA"18579281
C013698tallowtallow affects the expression of ARSG mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ARSG mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ARSG mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of ARSG mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARSG gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ARSG mRNA28213091|2892240
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ARSG mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ARSG mRNA25613284
C012589trichostatin Atrichostatin A results in decreased expression of ARSG mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ARSG mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ARSG mRNA29024780
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARSG mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of ARSG mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in decreased methylation of ARSG gene29154799
D014635Valproic AcidValproic Acid affects the expression of ARSG mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ARSG gene25560391
D014752Vinyl ChlorideVinyl Chloride results in increased expression of ARSG mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004065arylsulfatase activity-IDA18283100  
GO:0004065arylsulfatase activityNOTIDA12461688  
GO:0004065arylsulfatase activity-TAS16174644  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006790sulfur compound metabolic process-IDA18283100  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA18283100  
GO:0005764lysosome-IDA18283100  
GO:0005783endoplasmic reticulum-IDA12461688  
GO:0005788endoplasmic reticulum lumen-TAS-  
KEGG ID KEGG Term
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activationTAS
R-HSA-1660662Glycosphingolipid metabolismTAS
R-HSA-1663150The activation of arylsulfatasesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-428157Sphingolipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal