Gene: TRAK1

22906
MILT1|OIP106
trafficking kinesin protein 1
protein-coding
3p22.1
Ensembl:ENSG00000182606 MIM:608112 Vega:OTTHUMG00000131795 UniprotKB:Q9UPV9
NC_000003.12
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.025e-1 (AD)  5.279e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1043610chr3:42224142 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3774391chr3:42223877 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs11928109chr3:42217807 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs4234445chr3:42184659 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLASP10.935
FAM168A0.931
ITSN10.927
LONP20.925
FOXO30.921
LASP10.919
ASTN10.919
SYNE10.916
WIPF20.915
CKAP50.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.67
OR4F29-0.611
CTNNA3-0.38
SH2D1A-0.376
SGMS2-0.374
TNFRSF13B-0.354
TFPI2-0.354
ANXA13-0.353
GNG8-0.346
NANOGNB-0.343

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TRAK1 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in increased expression of TRAK1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TRAK1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TRAK1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of TRAK1 mRNA24449571
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TRAK1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRAK1 mRNA22228805
C006780bisphenol Abisphenol A results in decreased methylation of TRAK1 promoter27312807
C006780bisphenol Abisphenol A affects the expression of TRAK1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of TRAK1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of TRAK1 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of TRAK1 mRNA26079696
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of TRAK1 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRAK1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of TRAK1 mRNA19376846
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TRAK1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of TRAK1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of TRAK1 mRNA27392435
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of TRAK1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of TRAK1 mRNA18042831|1946730
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of TRAK1 mRNA17555576
D005485FlutamideFlutamide results in decreased expression of TRAK1 mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRAK1 mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of TRAK1 mRNA23649840
D007538IsoniazidIsoniazid affects the expression of TRAK1 mRNA24848797
D007545IsoproterenolIsoproterenol results in decreased expression of TRAK1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of TRAK1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TRAK1 mRNA23086925
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of TRAK1 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of TRAK1 mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TRAK1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TRAK1 mRNA"20188158
C051752nefazodonenefazodone results in decreased expression of TRAK1 mRNA24136188
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TRAK1 mRNA"12756304
C025589ochratoxin Aochratoxin A results in decreased expression of TRAK1 mRNA22124623
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TRAK1 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of TRAK1 mRNA18042831
C006253pirinixic acidpirinixic acid results in decreased expression of TRAK1 mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of TRAK1 mRNA18301758
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TRAK1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of TRAK1 mRNA25895662
D013629TamoxifenTamoxifen affects the expression of TRAK1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRAK1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TRAK1 mRNA15328365
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TRAK1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of TRAK1 mRNA20488242
C057693troglitazonetroglitazone results in increased expression of TRAK1 mRNA19140230
C080163trovafloxacintrovafloxacin results in increased expression of TRAK1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of TRAK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TRAK1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of TRAK1 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRAK1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of TRAK1 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO:0005515protein binding-IPI15644324  16630562  18675823  19135897  19528298  24995978  
27705803  
GO:0017022myosin binding-IBA21873635  
GO:0030911TPR domain binding-IEA-  
GO:0050811GABA receptor binding-IBA21873635  
GO:0050811GABA receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-ISS-  
GO:0006493protein O-linked glycosylation-ISS-  
GO:0006605protein targeting-IBA21873635  
GO:0006605protein targeting-ISS-  
GO:0008089anterograde axonal transport-IBA21873635  
GO:0008104protein localization-IBA21873635  
GO:0008333endosome to lysosome transport-IBA21873635  
GO:0008333endosome to lysosome transport-IDA18675823  
GO:0022008neurogenesis-IBA21873635  
GO:0047496vesicle transport along microtubule-IBA21873635  
GO:0048311mitochondrion distribution-IBA21873635  
GO:0048813dendrite morphogenesis-IEA-  
GO:0050772positive regulation of axonogenesis-IEA-  
GO:0098957anterograde axonal transport of mitochondrion-IBA21873635  
GO:0098957anterograde axonal transport of mitochondrion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA19528298  
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA15644324  18675823  19528298  
GO:0005769early endosome-IDA18675823  
GO:0030425dendrite-IBA21873635  
GO:0030425dendrite-IEA-  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0032839dendrite cytoplasm-IBA21873635  
GO:0044295axonal growth cone-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:1904115axon cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6802952Signaling by BRAF and RAF fusionsTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal