Gene: CEP152

22995
MCPH4|MCPH9|SCKL5
centrosomal protein 152
protein-coding
15q21.1
Ensembl:ENSG00000103995 MIM:613529 Vega:OTTHUMG00000172219 UniprotKB:O94986
NG_027518.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.547e-1 (AD)  2.705e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11631496chr15:48783721 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2413913chr15:48718852 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AFF10.743
PKN20.715
ZNF5580.707
ZNF7610.7
SMAD40.695
ATF70.694
TBC1D2B0.692
DCLRE1C0.685
KIAA15510.682
NFATC30.68

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.505
ZSCAN1-0.458
VGF-0.443
SST-0.397
MYCNOS-0.375
GSG1-0.374
SPATA2L-0.358
PNOC-0.353
GGN-0.35
CYP1A1-0.342

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of CEP152 mRNA28522335
D000082AcetaminophenAcetaminophen results in increased expression of CEP152 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CEP152 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of CEP152 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CEP152 mRNA28522335
D001379AzathioprineAzathioprine results in decreased expression of CEP152 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of CEP152 mRNA22323515
D004958EstradiolEstradiol results in increased expression of CEP152 mRNA19167446
C006780bisphenol Abisphenol A affects the expression of CEP152 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of CEP152 mRNA29275510
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of CEP152 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of CEP152 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CEP152 mRNA26079696
C018021cobaltous chloridecobaltous chloride results in increased expression of CEP152 mRNA24386269
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of CEP152 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of CEP152 mRNA19167446
C029892cupric chloridecupric chloride results in decreased expression of CEP152 mRNA24650576
D016572CyclosporineCyclosporine results in increased expression of CEP152 mRNA25562108
D000069439DasatinibDasatinib results in decreased expression of CEP152 mRNA20579391
C000944dicrotophosdicrotophos results in decreased expression of CEP152 mRNA28302478
D002117CalcitriolCalcitriol results in decreased expression of CEP152 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of CEP152 mRNA21592394
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CEP152 mRNA23649840
C039281furanfuran results in increased expression of CEP152 mRNA26194646
D007213IndomethacinIndomethacin results in decreased expression of CEP152 mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CEP152 mRNA25613284
D007854LeadLead results in decreased expression of CEP152 mRNA19921347
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CEP152 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of CEP152 mRNA"26251327
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CEP152 mRNA19710929
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of CEP152 mRNA21334430
D011794QuercetinQuercetin affects the expression of CEP152 mRNA21632981
D011794QuercetinQuercetin results in increased expression of CEP152 protein14750173
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of CEP152 mRNA19167446
C059514resveratrolresveratrol results in increased expression of CEP152 mRNA19167446
D012402RotenoneRotenone results in increased expression of CEP152 mRNA19013527
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of CEP152 mRNA"26680231
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of CEP152 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of CEP152 mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of CEP152 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CEP152 mRNA21724226
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of CEP152 mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of CEP152 mRNA"26743178
D014635Valproic AcidValproic Acid results in decreased expression of CEP152 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20852615  21059844  21131973  24997597  26297806  26496610  
26638075  
GO:0019901protein kinase binding-IPI20852615  21059844  
GO ID GO Term Qualifier Evidence PubMed
GO:0000086G2/M transition of mitotic cell cycle-TAS-  
GO:0007099centriole replication-IBA21873635  
GO:0007099centriole replication-ISS-  
GO:0010389regulation of G2/M transition of mitotic cell cycle-TAS-  
GO:0051298centrosome duplication-IMP20852615  
GO:0097711ciliary basal body-plasma membrane docking-TAS-  
GO:0098535de novo centriole assembly involved in multi-ciliated epithelial cell differentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000242pericentriolar material-IDA26337392  
GO:0005654nucleoplasm-IDA-  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA21131973  21399614  
GO:0005814centriole-IDA22020124  26337392  
GO:0005829cytosol-TAS-  
GO:0098536deuterosome-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1640170Cell CycleTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionTAS
R-HSA-380259Loss of Nlp from mitotic centrosomesTAS
R-HSA-380270Recruitment of mitotic centrosome proteins and complexesTAS
R-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeTAS
R-HSA-380287Centrosome maturationTAS
R-HSA-380320Recruitment of NuMA to mitotic centrosomesTAS
R-HSA-453274Mitotic G2-G2/M phasesTAS
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5620912Anchoring of the basal body to the plasma membraneTAS
R-HSA-68877Mitotic PrometaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69275G2/M TransitionTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-8854518AURKA Activation by TPX2TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal