Gene: TNIK

23043
MRT54
TRAF2 and NCK interacting kinase
protein-coding
3q26.2-q26.31
Ensembl:ENSG00000154310 MIM:610005 Vega:OTTHUMG00000159036 UniprotKB:Q9UKE5
NG_054934.1
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.652e-1 (AD)  3.990e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11926949chr3:171377305 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4955765chr3:171113283 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07753510chr3:171111243TNIK2.000e-10Smoking27651444
cg10180092chr3:171002363TNIK4.000e-10Smoking27651444
cg14576319chr3:171175713TNIK1.800e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTRK20.874
EPB41L50.864
MSI20.859
DOCK70.854
ACOX10.851
NADK20.85
DAG10.848
BBS20.843
AHCYL20.84
EIF4EBP20.839

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.562
OR4F29-0.535
CETP-0.236
GAL-0.233
L1TD1-0.228
KLK8-0.225
SULT2B1-0.214
S1PR4-0.204
C17orf112-0.204
GADL1-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of TNIK mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TNIK mRNA"27291303
C0127962-butenal2-butenal results in decreased expression of TNIK mRNA20471460
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of TNIK mRNA17562736
C014949acetylhydrazineacetylhydrazine results in decreased expression of TNIK mRNA15282401
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TNIK protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of TNIK mRNA19770486
D001151ArsenicArsenic results in decreased expression of TNIK mRNA16835338
C015001arsenitearsenite results in decreased expression of TNIK mRNA23974009
C547126AZM551248AZM551248 results in decreased expression of TNIK mRNA22323515
C487081belinostatbelinostat results in increased expression of TNIK mRNA26272509|2718838
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNIK mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNIK mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNIK mRNA"20382639
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TNIK mRNA19619570
D004958EstradiolEstradiol results in increased expression of TNIK mRNA19619570|2118537
C006780bisphenol Abisphenol A results in increased expression of TNIK mRNA27685785
C006780bisphenol Abisphenol A affects the expression of TNIK mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of TNIK protein28903499
D002104CadmiumCadmium results in increased expression of TNIK mRNA23369406
D002737ChloropreneChloroprene results in increased expression of TNIK mRNA23125180
D003024ClozapineClozapine results in decreased expression of TNIK mRNA14647396
C018021cobaltous chloridecobaltous chloride results in decreased expression of TNIK mRNA19320972
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of TNIK protein20931265
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TNIK mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TNIK mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of TNIK mRNA18503570
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TNIK mRNA24535843
C118739entinostatentinostat results in increased expression of TNIK mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNIK mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of TNIK mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of TNIK mRNA23649840
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of TNIK mRNA22467014
D006220HaloperidolHaloperidol results in decreased expression of TNIK mRNA14647396
D007545IsoproterenolIsoproterenol results in increased expression of TNIK mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TNIK mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TNIK mRNA24796395
D007657Ketone BodiesKetone Bodies results in increased expression of TNIK mRNA16807920
C008261lead acetatelead acetate results in decreased expression of TNIK mRNA22641619
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of TNIK mRNA"24972896
C042720mercuric bromidemercuric bromide results in increased expression of TNIK mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TNIK mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNIK mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNIK mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNIK mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of TNIK mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of TNIK mRNA22714537
C030110oxaliplatinoxaliplatin results in increased expression of TNIK mRNA16510598
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of TNIK mRNA26272509
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TNIK mRNA26272509
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TNIK mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TNIK mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of TNIK mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of TNIK mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of TNIK mRNA23012394
C005556propionaldehydepropionaldehyde results in increased expression of TNIK mRNA26079696
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNIK mRNA19059307
C009277sodium arsenatesodium arsenate results in increased expression of TNIK mRNA21795629
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of TNIK mRNA22467014
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of TNIK mRNA19059307
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TNIK mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNIK mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNIK mRNA19933214
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of TNIK protein20931265
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TNIK mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TNIK mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of TNIK mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of TNIK mRNA17963808
D014638VanadatesVanadates results in increased expression of TNIK mRNA22714537
C025643vinclozolinvinclozolin affects the expression of TNIK mRNA19015723
C029297vinylidene chloridevinylidene chloride results in increased expression of TNIK mRNA26682919
D014810Vitamin EVitamin E results in decreased expression of TNIK mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNIK mRNA"27188386
C111237vorinostatvorinostat results in increased expression of TNIK mRNA26272509|2718838

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA22797597  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA10521462  15342639  
GO:0005515protein binding-IPI10521462  15342639  18930710  19816403  20159449  22904686  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000185activation of MAPKKK activity-IEA-  
GO:0001934positive regulation of protein phosphorylation-IMP22797597  
GO:0006468protein phosphorylation-IDA10521462  15342639  22797597  
GO:0007010cytoskeleton organization-IMP10521462  
GO:0007256activation of JNKK activity-IDA15342639  
GO:0007256activation of JNKK activity-IMP10521462  
GO:0007346regulation of mitotic cell cycle-IBA21873635  
GO:0016055Wnt signaling pathway-IEA-  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0030033microvillus assembly-IMP22797597  
GO:0031532actin cytoskeleton reorganization-IDA15342639  
GO:0032147activation of protein kinase activity-IBA21873635  
GO:0035556intracellular signal transduction-IDA10521462  
GO:0046777protein autophosphorylation-IDA10521462  15342639  
GO:0048812neuron projection morphogenesis-IBA21873635  
GO:0048814regulation of dendrite morphogenesis-IDA20159449  
GO:0072659protein localization to plasma membrane-IMP22797597  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19816403  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA15342639  19061864  
GO:0005829cytosol-IDA-  
GO:0005856cytoskeleton-IDA15342639  
GO:0016324apical plasma membrane-IDA22797597  
GO:0055037recycling endosome-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal