Gene: ZHX3

23051
TIX1
zinc fingers and homeoboxes 3
protein-coding
20q12
Ensembl:ENSG00000174306 MIM:609598 Vega:OTTHUMG00000032481 UniprotKB:Q9H4I2
NG_046923.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.092e-1 (AD)  3.561e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6129784chr20:41256889 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADCYAP1R10.87
TBC1D160.867
ABLIM10.862
BBS20.858
TPCN10.856
SALL20.854
PC0.842
DAG10.84
LRRC8A0.839
CDH200.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.639
OR4F29-0.609
GALR1-0.365
C9orf135-0.355
GADL1-0.354
GZMA-0.352
CD8B-0.348
CLEC6A-0.346
KRTAP1-1-0.343
CD3G-0.336

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ZHX3 mRNA"28903501
C0127962-butenal2-butenal results in decreased expression of ZHX3 mRNA20471460
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ZHX3 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ZHX3 protein]26598702
D000452AldrinAldrin results in decreased expression of ZHX3 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ZHX3 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ZHX3 mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ZHX3 protein]26598702
D001280AtrazineAtrazine results in increased expression of ZHX3 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZHX3 mRNA20064835|2623829
C006780bisphenol Abisphenol A results in decreased expression of ZHX3 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of ZHX3 mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ZHX3 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of ZHX3 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of ZHX3 mRNA21932408
C006780bisphenol Abisphenol A results in decreased expression of ZHX3 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of ZHX3 mRNA26191083
D002994ClofibrateClofibrate results in decreased expression of ZHX3 mRNA23811191
D003042CocaineCocaine affects the expression of ZHX3 mRNA20187946
D003300Copper[Disulfiram binds to Copper] which results in increased expression of ZHX3 mRNA24690739
D003520CyclophosphamideCyclophosphamide results in decreased expression of ZHX3 mRNA27281708
D016572CyclosporineCyclosporine results in decreased expression of ZHX3 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ZHX3 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of ZHX3 mRNA22733784
C000944dicrotophosdicrotophos results in increased expression of ZHX3 mRNA28302478
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of ZHX3 mRNA24690739
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZHX3 mRNA22079256
C492448ICG 001ICG 001 results in increased expression of ZHX3 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ZHX3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ZHX3 mRNA28628672
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of ZHX3 mRNA22563483
D008727MethotrexateMethotrexate results in increased expression of ZHX3 mRNA17400583
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ZHX3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ZHX3 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of ZHX3 mRNA19167457
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of ZHX3 mRNA22563483
D010269ParaquatParaquat results in increased expression of ZHX3 mRNA22563483
D010938Plant OilsPlant Oils results in decreased expression of ZHX3 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZHX3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ZHX3 mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of ZHX3 mRNA20726854
C045950propiconazolepropiconazole results in decreased expression of ZHX3 mRNA21278054
C428725pyridabenpyridaben results in increased expression of ZHX3 mRNA22563483
C017947sodium arsenitesodium arsenite results in increased expression of ZHX3 mRNA28595984
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZHX3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZHX3 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZHX3 mRNA24058054
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ZHX3 mRNA28065790
C057693troglitazonetroglitazone results in decreased expression of ZHX3 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of ZHX3 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ZHX3 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of ZHX3 mRNA17292431
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of ZHX3 mRNA18579281

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IDA12659632  
GO:0003714transcription corepressor activity-IBA21873635  
GO:0005515protein binding-IPI12659632  21516116  25416956  
GO:0042803protein homodimerization activity-IDA12659632  
GO:0046872metal ion binding-IEA-  
GO:0046982protein heterodimerization activity-IDA12659632  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0030154cell differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IMP21174497  
GO:0045892negative regulation of transcription, DNA-templated-IDA12659632  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA12659632  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal