Gene: ZNF609

23060
-
zinc finger protein 609
protein-coding
15q22.31
Ensembl:ENSG00000180357 MIM:617474 Vega:OTTHUMG00000172370 UniprotKB:O15014
NC_000015.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.563e-1 (AD)  2.270e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2899699chr15:64620720 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PEAK10.89
NSD10.887
SPEN0.878
HUWE10.875
EP3000.862
ANKRD170.857
ZNF4450.852
MCM3AP0.85
MDN10.85
CDC42BPA0.848

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.522
OR4F5-0.506
ODAM-0.28
GSDMC-0.277
UTS2-0.276
IRX5-0.275
SIM1-0.264
RPE65-0.262
S100A14-0.262
IL20RA-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ZNF609 mRNA22100608
D001151ArsenicArsenic affects the methylation of ZNF609 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ZNF609 mRNA20064835
C006780bisphenol Abisphenol A affects the expression of ZNF609 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ZNF609 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ZNF609 mRNA26079696
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ZNF609 mRNA24317228
D002945CisplatinCisplatin results in decreased expression of ZNF609 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of ZNF609 mRNA28302478
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ZNF609 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZNF609 mRNA22079256
D007854LeadLead results in decreased expression of ZNF609 mRNA19921347
C045463leflunomideleflunomide results in increased expression of ZNF609 mRNA28988120
C005219methyl cellosolvemethyl cellosolve results in decreased expression of ZNF609 mRNA21061450
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of ZNF609 mRNA23948077
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ZNF609 mRNA21061450
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ZNF609 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ZNF609 mRNA22079256
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ZNF609 mRNA"26179874
D014520UrethaneUrethane results in increased expression of ZNF609 mRNA28818685

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-ISS-  
GO:0007517muscle organ development-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:2000291regulation of myoblast proliferation-IDA28344082  
GO:2001224positive regulation of neuron migration-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA28344082  
GO:0005654nucleoplasm-IDA-  
GO:0032039integrator complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal