Gene: KDM4C

23081
GASC1|JHDM3C|JMJD2C|TDRD14C
lysine demethylase 4C
protein-coding
9p24.1
Ensembl:ENSG00000107077 MIM:605469 Vega:OTTHUMG00000187508 UniprotKB:Q9H3R0
NC_000009.12
SNP Mapped
5   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.247e-1 (AD)  3.464e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7034275chr9:7067344 (GRCh38.p7)G>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs1407862chr9:7032776 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10758821chr9:7030268 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs10975990chr9:7026716 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11998950chr9:6811507 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NVL0.874
PRPF390.864
NOM10.861
CSPP10.857
DMTF10.855
COG30.855
ZC3H11A0.854
TUBE10.854
MDN10.853
TXLNG0.851

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.481
OR4F29-0.468
TRDN-0.283
GLI1-0.254
ASB4-0.252
OR4F16-0.249
PON3-0.247
TNNT1-0.246
DIAPH3-0.242
S100A1-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0341931,2-diaminobenzene"KDM4C gene SNP affects the susceptibility to 1,2-diaminobenzene"25622337
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDM4C mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDM4C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDM4C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDM4C mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of KDM4C mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of KDM4C protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KDM4C mRNA22100608
D001280AtrazineAtrazine results in decreased expression of KDM4C mRNA22378314
C487081belinostatbelinostat results in increased expression of KDM4C mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KDM4C mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KDM4C mRNA"26238291
C018475butyraldehydebutyraldehyde results in decreased expression of KDM4C mRNA26079696
D003471CuprizoneCuprizone affects the expression of KDM4C mRNA27523638
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of KDM4C mRNA27392435
D002945CisplatinCisplatin results in decreased expression of KDM4C mRNA24280081|2759478
D002945CisplatinCisplatin results in decreased expression of KDM4C mRNA24280081
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of KDM4C mRNA26924002
D004237DiuronDiuron results in increased expression of KDM4C mRNA25152437
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KDM4C mRNA22079256
C069837fullerene C60fullerene C60 affects the expression of KDM4C mRNA19167457
C071834glycidamideglycidamide affects the expression of KDM4C protein21978862
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KDM4C mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of KDM4C mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of KDM4C mRNA24796395
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of KDM4C mRNA26378955
C517284monomethyl phthalatemonomethyl phthalate affects the expression of KDM4C mRNA26924002
D009151Mustard GasMustard Gas results in decreased expression of KDM4C mRNA26392148
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KDM4C mRNA"25554681
D009532NickelNickel affects the activity of KDM4C protein23692052
C028007nickel monoxidenickel monoxide results in decreased expression of KDM4C mRNA19167457
D009569Nitric OxideNitric Oxide results in increased expression of KDM4C mRNA23546878
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of KDM4C mRNA18593933
C046012pentanalpentanal results in decreased expression of KDM4C mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDM4C mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of KDM4C mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of KDM4C mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of KDM4C mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of KDM4C mRNA22079256
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of KDM4C mRNA26378955
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of KDM4C mRNA20189893
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of KDM4C mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KDM4C mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of KDM4C mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KDM4C mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of KDM4C mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of KDM4C mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of KDM4C gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of KDM4C mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0003682chromatin binding-IBA21873635  
GO:0003682chromatin binding-IEA-  
GO:0008270zinc ion binding-IDA21914792  
GO:0019899enzyme binding-IPI17277772  
GO:0032452histone demethylase activity-EXP18066052  
GO:0032452histone demethylase activity-IBA21873635  
GO:0032452histone demethylase activity-TAS-  
GO:0032454histone demethylase activity (H3-K9 specific)-IBA21873635  
GO:0032454histone demethylase activity (H3-K9 specific)-IDA18066052  21914792  
GO:0032454histone demethylase activity (H3-K9 specific)-IMP17277772  28262558  
GO:0035064methylated histone binding-IBA21873635  
GO:0050681androgen receptor binding-IPI17277772  
GO:0051864histone demethylase activity (H3-K36 specific)-IBA21873635  
GO:0051864histone demethylase activity (H3-K36 specific)-IDA21914792  
GO ID GO Term Qualifier Evidence PubMed
GO:0001825blastocyst formation-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IDA17277772  
GO:0008284positive regulation of cell proliferation-IMP17277772  
GO:0010628positive regulation of gene expression-IEA-  
GO:0033169histone H3-K9 demethylation-IDA18066052  21914792  
GO:0033169histone H3-K9 demethylation-IMP17277772  28262558  
GO:0045666positive regulation of neuron differentiation-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0070544histone H3-K36 demethylation-IDA21914792  
GO:1900113negative regulation of histone H3-K9 trimethylation-IEA-  
GO:2000036regulation of stem cell population maintenance-IEA-  
GO:2000736regulation of stem cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA17277772  
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-TAS-  
GO:0005721pericentric heterochromatin-IEA-  
GO:0035097histone methyltransferase complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-3214842HDMs demethylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5625740RHO GTPases activate PKNsTAS
R-HSA-5625886Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal