Gene: FRMD4B

23150
6030440G05Rik|GRSP1
FERM domain containing 4B
protein-coding
3p14.1
Ensembl:ENSG00000114541 MIM:617467 Vega:OTTHUMG00000158772 UniprotKB:Q9Y2L6
NG_034059.1
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.307e-1 (AD)  5.246e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs112196420chr3:69450652 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs13066342chr3:69320145 (GRCh38.p7)C>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ST180.935
PLD10.929
C21orf910.927
SH3TC20.919
TMCC30.919
PRR5L0.915
FOLH10.914
C10orf900.912
ASPA0.911
EVI2A0.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.497
PCDH8-0.452
NEUROD1-0.444
CHRNA2-0.439
CALB2-0.435
CDH22-0.425
LTK-0.424
PRTN3-0.423
SHISA8-0.419
CNGB1-0.417

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of FRMD4B mRNA"18648102
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased phosphorylation of FRMD4B protein"2147426
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"N-(2-aminoethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased phosphorylation of FRMD4B protein]"2147426
C0159298-((4-chlorophenyl)thio)cyclic-3',5'-AMP"staurosporine aglycone inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased phosphorylation of FRMD4B protein]"2147426
D000082AcetaminophenAcetaminophen affects the expression of FRMD4B mRNA17562736
D000452AldrinAldrin results in increased expression of FRMD4B mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FRMD4B mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of FRMD4B mRNA24449571
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FRMD4B mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FRMD4B mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FRMD4B mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FRMD4B mRNA27858113
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FRMD4B mRNA19619570
D004958EstradiolEstradiol results in increased expression of FRMD4B mRNA19619570
D004958EstradiolEstradiol results in increased expression of FRMD4B mRNA19484750
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of FRMD4B mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of FRMD4B mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of FRMD4B mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of FRMD4B mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FRMD4B mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of FRMD4B mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of FRMD4B mRNA23811191
D003471CuprizoneCuprizone results in decreased expression of FRMD4B mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of FRMD4B mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of FRMD4B mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of FRMD4B mRNA23625948
D004041Dietary FatsDietary Fats affects the expression of FRMD4B mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of FRMD4B mRNA18042831|2501614
D004041Dietary FatsDietary Fats results in increased expression of FRMD4B mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in increased expression of FRMD4B mRNA]19030233
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of FRMD4B mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of FRMD4B mRNA17942748
C069837fullerene C60fullerene C60 results in decreased expression of FRMD4B mRNA19167457
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FRMD4B mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of FRMD4B mRNA24796395
C008261lead acetatelead acetate results in decreased expression of FRMD4B mRNA22609695
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FRMD4B mRNA21641980
D008558MelphalanMelphalan results in decreased expression of FRMD4B mRNA22363485
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of FRMD4B mRNA23179753|2800136
C500085muraglitazarmuraglitazar results in decreased expression of FRMD4B mRNA21515302
C044388N-(2-aminoethyl)-5-isoquinolinesulfonamide"N-(2-aminoethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased phosphorylation of FRMD4B protein]"2147426
C044388N-(2-aminoethyl)-5-isoquinolinesulfonamideN-(2-aminoethyl)-5-isoquinolinesulfonamide inhibits the reaction [Okadaic Acid results in increased phosphorylation of FRMD4B protein]2147426
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FRMD4B mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FRMD4B mRNA"25554681|2562005
D019319Okadaic AcidN-(2-aminoethyl)-5-isoquinolinesulfonamide inhibits the reaction [Okadaic Acid results in increased phosphorylation of FRMD4B protein]2147426
D019319Okadaic AcidOkadaic Acid results in increased phosphorylation of FRMD4B protein2147426
D019319Okadaic Acidstaurosporine aglycone inhibits the reaction [Okadaic Acid results in increased phosphorylation of FRMD4B protein]2147426
D000073878Palm OilPalm Oil affects the expression of FRMD4B mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of FRMD4B mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of FRMD4B mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of FRMD4B mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of FRMD4B mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of FRMD4B mRNA18445702
C005556propionaldehydepropionaldehyde results in decreased expression of FRMD4B mRNA26079696
D011794QuercetinQuercetin results in decreased expression of FRMD4B mRNA21632981
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in increased expression of FRMD4B mRNA]19030233
C089730rosiglitazonerosiglitazone results in decreased expression of FRMD4B mRNA21515302
D012822Silicon DioxideSilicon Dioxide results in decreased expression of FRMD4B mRNA19073995
D012906SmokeSmoke results in decreased expression of FRMD4B mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of FRMD4B mRNA21795629
C049985staurosporine aglycone"staurosporine aglycone inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased phosphorylation of FRMD4B protein]"2147426
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [Okadaic Acid results in increased phosphorylation of FRMD4B protein]2147426
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of FRMD4B mRNA21641980
C013698tallowtallow affects the expression of FRMD4B mRNA19680557
C501413tesaglitazartesaglitazar results in decreased expression of FRMD4B mRNA21515302
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of FRMD4B mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FRMD4B mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FRMD4B mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FRMD4B mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of FRMD4B protein27818348
D014212TretinoinTretinoin results in increased expression of FRMD4B mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of FRMD4B mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of FRMD4B mRNA28973697
C057693troglitazonetroglitazone results in decreased expression of FRMD4B mRNA21515302
D014520UrethaneUrethane results in increased expression of FRMD4B mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of FRMD4B mRNA24935251
D001335Vehicle EmissionsVehicle Emissions affects the methylation of FRMD4B gene25560391
C025643vinclozolinvinclozolin results in decreased expression of FRMD4B mRNA23034163
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of FRMD4B mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0090162establishment of epithelial cell polarity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001726ruffle-IEA-  
GO:0005615extracellular space-HDA23580065  
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0005912adherens junction-IEA-  
GO:0005923bicellular tight junction-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal