Gene: GRAMD4

23151
DIP|dA59H18.1|dJ439F8.1
GRAM domain containing 4
protein-coding
22q13.31
Ensembl:ENSG00000075240 MIM:613691 Vega:OTTHUMG00000150402 UniprotKB:Q6IC98
NC_000022.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.699e-1 (AD)  2.849e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs875778chr22:46588409 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABR0.922
SIRPA0.907
KNDC10.905
PTPRS0.901
CHST100.899
GRIK50.898
PTPRF0.897
LRRC140.895
RPTOR0.895
MEGF80.895

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.617
OR4F29-0.551
TFPI2-0.463
IGF2BP2-0.446
CLEC2B-0.44
CD48-0.44
IL18RAP-0.439
PROK2-0.43
DTHD1-0.428
SH2D1A-0.426

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GRAMD4 mRNA28329830
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRAMD4 mRNA"19114083
D001151ArsenicArsenic affects the methylation of GRAMD4 gene25304211
D001280AtrazineAtrazine results in decreased expression of GRAMD4 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of GRAMD4 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRAMD4 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRAMD4 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GRAMD4 mRNA"26238291
C044887beta-methylcholinebeta-methylcholine affects the expression of GRAMD4 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of GRAMD4 mRNA25047013|2927551
C006780bisphenol Abisphenol A results in decreased expression of GRAMD4 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of GRAMD4 mRNA23798566
C006780bisphenol Abisphenol A results in decreased expression of GRAMD4 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of GRAMD4 mRNA26079696
D002945CisplatinCisplatin promotes the reaction [jinfukang results in increased expression of GRAMD4 mRNA]27392435
D002945CisplatinCisplatin promotes the reaction [[TP73 protein binds to GRAMD4 promoter] which results in increased expression of GRAMD4 mRNA]21127500|2112750
D002945CisplatinCisplatin results in decreased expression of GRAMD4 mRNA27594783
D002945CisplatinCisplatin results in increased expression of GRAMD4 mRNA27392435
D002945Cisplatinjinfukang promotes the reaction [Cisplatin results in increased expression of GRAMD4 mRNA]27392435
D002945CisplatinTP73 protein promotes the reaction [Cisplatin results in increased expression of GRAMD4 mRNA]21127500
D002117CalcitriolCalcitriol results in increased expression of GRAMD4 mRNA16002434
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of GRAMD4 mRNA28329830
C007738fluoranthenefluoranthene results in increased expression of GRAMD4 mRNA28329830
D005472FluorouracilFluorouracil results in increased expression of GRAMD4 mRNA21127500
D005472FluorouracilTP73 protein promotes the reaction [Fluorouracil results in increased expression of GRAMD4 mRNA]21127500
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRAMD4 mRNA25613284
C544151jinfukangCisplatin promotes the reaction [jinfukang results in increased expression of GRAMD4 mRNA]27392435
C544151jinfukangjinfukang promotes the reaction [Cisplatin results in increased expression of GRAMD4 mRNA]27392435
C544151jinfukangjinfukang results in increased expression of GRAMD4 mRNA27392435
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of GRAMD4 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GRAMD4 mRNA"25554681
C006253pirinixic acidpirinixic acid results in increased expression of GRAMD4 mRNA23811191
D011441PropylthiouracilPropylthiouracil results in increased expression of GRAMD4 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GRAMD4 mRNA25895662
D018038Sodium SeleniteSodium Selenite results in decreased expression of GRAMD4 mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GRAMD4 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of GRAMD4 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GRAMD4 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GRAMD4 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of GRAMD4 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of GRAMD4 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of GRAMD4 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of GRAMD4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GRAMD4 mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of GRAMD4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of GRAMD4 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006915apoptotic process-IEA-  
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process-IMP15565177  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IDA15565177  
GO:0016021integral component of membrane-IEA-  
GO:0031966mitochondrial membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal