Gene: FLT1

2321
FLT|FLT-1|VEGFR-1|VEGFR1
fms related tyrosine kinase 1
protein-coding
13q12.3
Ensembl:ENSG00000102755 MIM:165070 Vega:OTTHUMG00000016648 UniprotKB:P17948
NG_012003.1
PubMed|SNP Mapped
ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.579e-1 (AD)  4.959e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7981680chr13:28319733 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PODXL0.87
TGFBR20.858
TGM20.856
MMRN20.843
ABCB10.835
ESAM0.834
LEF10.829
MYCT10.827
MECOM0.823
AFAP1L10.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.403
ZSCAN1-0.388
C1orf53-0.367
CDT1-0.362
SMIM18-0.36
CORT-0.35
MYCNOS-0.347
CPLX3-0.347
NKX2-8-0.346
SP9-0.346

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00398SorafenibSmall Molecule284461-73-0Approved|InvestigationalTarget
DB01268SunitinibSmall Molecule557795-19-4Approved|InvestigationalTarget
DB04879VatalanibSmall Molecule212141-54-3InvestigationalTarget
DB05075TG-100801Small MoleculeInvestigationalTarget
DB05913OSI-930Small MoleculeInvestigationalTarget
DB05932DenibulinSmall Molecule284019-34-7InvestigationalTarget
DB06080ABT-869Small Molecule-InvestigationalTarget
DB06101IMC-1C11BiotechDrug-InvestigationalTarget
DB06589PazopanibSmall Molecule444731-52-6ApprovedTarget
DB06626AxitinibSmall Molecule319460-85-0Approved|InvestigationalTarget
DB07288N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamideSmall MoleculeExperimentalTarget
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
DB09078LenvatinibSmall Molecule417716-92-8Approved|InvestigationalTarget
DB09079NintedanibSmall Molecule656247-17-5ApprovedTarget
DB09221PolaprezincSmall Molecule107667-60-7Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of FLT1 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLT1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLT1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLT1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLT1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLT1 mRNA"25510870
C4874042-furoyl-LIGRLO-amide2-furoyl-LIGRLO-amide results in increased expression of FLT1 mRNA26933402
C4874042-furoyl-LIGRLO-amideresveratrol inhibits the reaction [2-furoyl-LIGRLO-amide results in increased expression of FLT1 mRNA]26933402
C4874042-furoyl-LIGRLO-amideresveratrol inhibits the reaction [2-furoyl-LIGRLO-amide results in increased secretion of FLT1 protein]26933402
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of FLT1 mRNA"23196670
C4776393-(5-methyl-2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acid"3-(5-methyl-2-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)propionic acid results in decreased activity of FLT1 protein"12766257
C575425(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline"(4-(4'-chloro-2'-fluoro)phenylamino)-6,7-dimethylquinazoline results in decreased activity of FLT1 protein"22573732
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C5610525H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of FLT1 protein"21608528
C0528535-hydroxydecanoic acid5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid results in decreased expression of FLT1 protein"17992120
C1217077,3'-dihydroxy-4'-methoxyisoflavone"7,3'-dihydroxy-4'-methoxyisoflavone results in increased expression of FLT1 mRNA"20686605
D000082AcetaminophenAcetaminophen results in decreased expression of FLT1 mRNA27761495
D000082AcetaminophenAcetaminophen results in increased expression of FLT1 mRNA27761495|2906747
D000082AcetaminophenAcetaminophen affects the expression of FLT1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of FLT1 mRNA21135413
D000082AcetaminophenAcetaminophen results in increased expression of FLT1 protein16565415
D000082AcetaminophenFLT1 protein affects the reaction [Acetaminophen results in decreased expression of IL6 mRNA]21135413
D000082AcetaminophenFLT1 protein affects the reaction [Acetaminophen results in increased expression of FGF2 mRNA]21135413
D000082AcetaminophenFLT1 protein affects the reaction [Acetaminophen results in increased expression of HGF mRNA]21135413
D000082AcetaminophenFLT1 protein affects the reaction [Acetaminophen results in increased expression of MMP9 mRNA]21135413
D000082AcetaminophenFLT1 protein affects the reaction [Acetaminophen results in increased expression of MMP9 protein]21135413
D000082AcetaminophenFLT1 protein affects the reaction [Acetaminophen results in increased expression of PECAM1 mRNA]21135413
D000082AcetaminophenFLT1 protein affects the reaction [Acetaminophen results in increased expression of TNF mRNA]21135413
D000111AcetylcysteineAcetylcysteine results in increased expression of FLT1 protein17992120
C096064acteinactein results in increased expression of FLT1 mRNA19527300
C016601afimoxifeneafimoxifene results in decreased secretion of FLT1 protein19828145
D000537Aluminum OxideAluminum Oxide results in increased expression of FLT1 mRNA19464052
D000643Ammonium ChlorideAmmonium Chloride affects the expression of FLT1 mRNA16483693
C030419andrographolideandrographolide results in decreased expression of FLT1 mRNA28651835
C006632arsenic trioxidearsenic trioxide results in decreased expression of FLT118161919
C006632arsenic trioxidearsenic trioxide results in increased expression of FLT1 mRNA15073043
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased secretion of FLT1 protein"21762757
D017638Asbestos, Crocidolite"tyrphostin AG 1478 inhibits the reaction [Asbestos, Crocidolite results in increased secretion of FLT1 protein]"21762757
D001205Ascorbic AcidAscorbic Acid results in decreased expression of FLT1 mRNA21919647
C503983axitinibaxitinib results in decreased activity of FLT119652060
D001372Aza CompoundsAza Compounds results in decreased expression of FLT1 mRNA20521778
C487081belinostatbelinostat results in increased expression of FLT1 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene affects the reaction [AHR protein binds to FLT1 promoter]19654925
D004958EstradiolEstradiol results in decreased expression of FLT1 mRNA19828145
D004958EstradiolEstradiol results in decreased secretion of FLT1 protein19828145
D001663BilirubinBilirubin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]25371888
C006780bisphenol Abisphenol A affects the expression of FLT1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of FLT1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of FLT1 mRNA25181051
C099813bromochloroacetic acidbromochloroacetic acid results in decreased expression of FLT1 protein21296659
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of FLT1 mRNA15878706
D002104CadmiumCadmium results in increased expression of FLT1 mRNA23256528
D002104CadmiumCadmium results in increased activity of FLT1 protein25343777
C031293calcium silicatecalcium silicate results in increased secretion of FLT1 protein21762757
C031293calcium silicatetyrphostin AG 1478 inhibits the reaction [calcium silicate results in increased secretion of FLT1 protein]21762757
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of FLT1 protein23845850
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]23845850
D002737ChloropreneChloroprene results in increased expression of FLT1 mRNA23125180
D002784CholesterolCholesterol results in increased expression of FLT1 mRNA26296894
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FLT1 gene20938992
D003008CloprostenolCloprostenol results in decreased expression of FLT1 mRNA14991729
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]25371888
C018021cobaltous chloridecobaltous chloride results in decreased expression of FLT1 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in increased expression of FLT1 mRNA24840734
C018021cobaltous chloridecobaltous chloride results in increased expression of FLT1 protein24840734
C018021cobaltous chloridephenylmethylpyrazolone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 mRNA]24840734
C018021cobaltous chloridephenylmethylpyrazolone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 protein]24840734
C000511cornin iridoidFLT1 protein alternative form inhibits the reaction [cornin iridoid results in increased expression of VEGFA protein]23702325
C000511cornin iridoidFLT1 protein alternative form results in decreased susceptibility to cornin iridoid23702325
D003345CorticosteroneCorticosterone results in increased expression of FLT1 mRNA15755911
D003474CurcuminCurcumin results in decreased expression of FLT1 protein18593936
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of FLT1 protein]23845850
D016572CyclosporineCyclosporine results in increased expression of FLT1 mRNA12110003
D016572Cyclosporine[Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]12110003
D016572Cyclosporinenilvadipine inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]12110003
D003703DemecolcineDemecolcine results in decreased expression of FLT1 mRNA23649840
D003907DexamethasoneDexamethasone results in increased expression of FLT1 mRNA19853017
D003981Diazoxide5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D003981DiazoxideDiazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]25371888
D003981DiazoxideHMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D003981Diazoxidezinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D002945CisplatinCisplatin results in increased expression of FLT1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of FLT121975929
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of FLT1 mRNA26924002
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of FLT1 mRNA20360939
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of FLT1 mRNA11981751|1987480
D004052Diethylnitrosaminelanreotide inhibits the reaction [Diethylnitrosamine results in increased expression of FLT1 mRNA]19874807
D002117CalcitriolCalcitriol results in increased expression of FLT1 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of FLT1 mRNA"21294050
D0151279,10-Dimethyl-1,2-benzanthracene"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FLT1 mRNA]"21294050
C024629dimethyl phthalatedimethyl phthalate affects the expression of FLT1 mRNA26924002
D004237DiuronDiuron results in increased expression of FLT1 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of FLT1 mRNA19277126
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased activity of FLT1 protein"25856345
C118739entinostatentinostat results in increased expression of FLT1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of FLT1 mRNA12655031
D000431EthanolEthanol results in increased expression of FLT1 mRNA22198099
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FLT1 mRNA17942748
C560274ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate"ethyl 8-oxo-8H-acenaphtho(1,2-b)pyrrole-9-carboxylate results in decreased activity of FLT1 protein"21517068
D005054EugenolEugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA]20434464
C069346fascaplysinefascaplysine analog results in decreased expression of FLT1 protein28756150
D005419FlavonoidsFlavonoids results in decreased expression of FLT1 mRNA18035473
D005472FluorouracilFluorouracil results in decreased expression of FLT1 protein18157009
D005472FluorouracilIFNA1 protein promotes the reaction [Fluorouracil results in decreased expression of FLT1 protein]18157009
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FLT1 gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of FLT1 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of FLT1 mRNA19167457
D005665FurosemideFurosemide results in increased expression of FLT1 mRNA16526316
C546771gardiquimodgardiquimod results in increased expression of FLT1 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FLT1 mRNA]28003376
C001277geldanamycingeldanamycin results in increased expression of FLT1 mRNA26705709
D005839GentamicinsGentamicins results in decreased expression of FLT1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of FLT1 mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]12110003
D006852Hydrochlorothiazide[Hydralazine co-treated with Hydrochlorothiazide] inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]12110003
C519562imetelstatimetelstat binds to and results in decreased activity of FLT1 protein21559248
D007211IndolesIndoles results in decreased expression of FLT1 mRNA20521778
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FLT1 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of FLT1 mRNA20003209
C060347lanreotidelanreotide inhibits the reaction [Diethylnitrosamine results in increased expression of FLT1 mRNA]19874807
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FLT1 protein"21843347
C440499lipopolysaccharide, Escherichia coli O111 B4"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FLT1 protein]"21843347
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of FLT1 mRNA25613284
D019808LosartanLosartan results in decreased expression of FLT1 mRNA19771429
D019808LosartanLosartan results in decreased expression of FLT1 protein19771429
C025340manganese chloridemanganese chloride results in increased expression of FLT1 mRNA17467022
C042720mercuric bromidemercuric bromide results in increased expression of FLT1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of FLT1 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of FLT1 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of FLT1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of FLT1 mRNA24213003
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of FLT1 protein24213003
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of FLT1 mRNA23649840
D008769MethylnitronitrosoguanidineEugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of FLT1 mRNA]20434464
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of FLT1 mRNA20434464
D015735MifepristoneMifepristone results in decreased expression of FLT1 mRNA25972201
C517284monomethyl phthalatemonomethyl phthalate affects the expression of FLT1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of FLT1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of FLT1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of FLT1 mRNA19812364
D009532NickelNickel results in increased expression of FLT1 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of FLT1 mRNA22714537
C035100nilvadipinenilvadipine inhibits the reaction [Cyclosporine results in increased expression of FLT1 mRNA]12110003
C419410N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester"N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FLT1 protein]"21843347
C086491NS 1619NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]25371888
C086491NS 1619paxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D009966OrphenadrineOrphenadrine affects the expression of FLT1 mRNA23665939
C030110oxaliplatinoxaliplatin results in increased expression of FLT1 protein18790786
D010100Oxygen5-hydroxydecanoic acid inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D010100OxygenBilirubin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]25371888
D010100Oxygencobaltiprotoporphyrin inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]25371888
D010100OxygenDiazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]25371888
D010100OxygenHMOX1 protein affects the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D010100OxygenNS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]25371888
D010100OxygenOxygen deficiency results in increased expression of FLT1 mRNA18679377|2537188
D010100OxygenOxygen deficiency results in increased expression of FLT1 protein25371888
D010100Oxygenpaxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D010100Oxygenzinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D010100OxygenOxygen deficiency results in increased expression of FLT1 mRNA10613739|1198175
D017239PaclitaxelPaclitaxel results in increased expression of FLT121975929
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of FLT1 mRNA26272509
C048220paxillinepaxilline inhibits the reaction [NS 1619 inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
C516667pazopanibpazopanib results in decreased activity of FLT1 protein19956806|2061637
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of FLT1 mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased activity of FLT1 protein21251949
D010634PhenobarbitalPhenobarbital results in increased expression of FLT1 mRNA12832660|1916217
D010656PhenylephrineFLT1 protein promotes the reaction [Phenylephrine results in increased activity of PRKG1 protein]19542178
D010656PhenylephrinePhenylephrine results in increased expression of FLT1 protein24903162
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of FLT1 mRNA26272509
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 mRNA]24840734
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [cobaltous chloride results in increased expression of FLT1 protein]24840734
D010705PhosgenePhosgene affects the expression of FLT1 protein15256155
D010705PhosgenePhosgene results in decreased expression of FLT1 mRNA18645720
D010705PhosgenePhosgene results in decreased expression of FLT1 protein18645720
C545373ponatinibponatinib analog results in decreased activity of FLT1 protein21561767
C545373ponatinibponatinib results in decreased activity of FLT1 protein19878872
D011192Potassium DichromatePotassium Dichromate results in increased expression of FLT1 mRNA23608068
D011192Potassium DichromateThioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA]23608068
D011374ProgesteroneProgesterone affects the expression of FLT1 mRNA17251523
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of FLT1 mRNA]28003376
D011692Puromycin AminonucleosidePuromycin Aminonucleoside affects the expression of FLT1 mRNA11744811
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of FLT1 protein14752241
D011794Quercetin"Quercetin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of FLT1 mRNA]"21294050
C059514resveratrolresveratrol inhibits the reaction [2-furoyl-LIGRLO-amide results in increased expression of FLT1 mRNA]26933402
C059514resveratrolresveratrol inhibits the reaction [2-furoyl-LIGRLO-amide results in increased secretion of FLT1 protein]26933402
C059514resveratrolresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of FLT1 protein]22197494
C059514resveratrolresveratrol results in decreased expression of FLT1 mRNA26933402
C059514resveratrolresveratrol results in decreased expression of FLT1 protein17992120
C059514resveratrolresveratrol results in decreased secretion of FLT1 protein22197494|2693340
C059514resveratrol[FLT1 protein results in decreased activity of VEGFA protein] inhibits the reaction [resveratrol results in increased expression of KDR protein modified form]22314268
C059514resveratrol[FLT1 protein results in decreased activity of VEGFA protein] inhibits the reaction [resveratrol results in increased secretion of MMP2 protein]22314268
C059514resveratrol[FLT1 protein results in decreased activity of VEGFA protein] inhibits the reaction [resveratrol results in increased secretion of MMP9 protein]22314268
C059514resveratrol[FLT1 protein results in decreased activity of VEGFA protein] which results in decreased susceptibility to resveratrol22314268
C059514resveratrolresveratrol inhibits the reaction [AGT protein modified form results in increased secretion of FLT1 protein]22197494
C059514resveratrolresveratrol inhibits the reaction [IFNG protein results in increased secretion of FLT1 protein]22197494
C059514resveratrolresveratrol inhibits the reaction [TNF protein results in increased secretion of FLT1 protein]22197494
C059514resveratrolresveratrol inhibits the reaction [VEGFA protein results in increased secretion of FLT1 protein]22197494
D012402RotenoneRotenone results in increased expression of FLT1 mRNA19013527
D012643SeleniumSelenium affects the expression of FLT1 mRNA19933425
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of FLT1 mRNA"16251409
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of FLT1 mRNA23806026
D012834SilverSilver results in decreased expression of FLT1 mRNA27131904
D019821SimvastatinSimvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA]20821229
D019821SimvastatinSimvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein]20821229
D019821SimvastatinSimvastatin results in increased expression of FLT1 mRNA19109527
C059295sinensetinsinensetin results in decreased expression of FLT1 mRNA22707269
C017947sodium arsenitesodium arsenite results in decreased expression of FLT1 mRNA12634122
D018038Sodium SeleniteSodium Selenite results in decreased expression of FLT1 mRNA18175754
C471405sorafenibsorafenib results in decreased activity of FLT1 protein20616376
D013311StreptozocinStreptozocin results in increased expression of FLT1 mRNA26073000
D013311StreptozocinSimvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA]20821229
D013311StreptozocinSimvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein]20821229
D013311StreptozocinStreptozocin results in increased expression of FLT1 mRNA20821229
D013311StreptozocinStreptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein20821229
C473478sunitinibsunitinib results in decreased activity of FLT1 protein20616376
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FLT1 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of FLT1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to FLT1 promoter]19654925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of FLT1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FLT1 mRNA19933214|2629044
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of FLT1 mRNA16495355
D013755Tetradecanoylphorbol AcetateATP7A protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FLT1 mRNA]19205902
D013755Tetradecanoylphorbol Acetateresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of FLT1 protein]22197494
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of FLT1 mRNA19205902
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of FLT1 protein22197494
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of FLT1 mRNA25613284
D013853ThioacetamideThioacetamide results in increased secretion of FLT1 protein27605418
D008063Thioctic AcidThioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FLT1 mRNA]23608068
D013893ThiramThiram results in decreased expression of FLT1 mRNA17954590
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of FLT1 gene26756918
D014050TolueneToluene results in increased expression of FLT1 mRNA22967744
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of FLT1 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of FLT1 mRNA28973697
C057693troglitazonetroglitazone results in increased expression of FLT1 mRNA17569031
C057693troglitazone[Urethane co-treated with troglitazone] results in increased expression of FLT1 mRNA18465119
D014415TunicamycinTunicamycin results in decreased expression of FLT1 mRNA24370435
C101044tyrphostin AG 1478"tyrphostin AG 1478 inhibits the reaction [Asbestos, Crocidolite results in increased secretion of FLT1 protein]"21762757
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [calcium silicate results in increased secretion of FLT1 protein]21762757
D014520Urethane[Urethane co-treated with troglitazone] results in increased expression of FLT1 mRNA18465119
D014520UrethaneUrethane results in increased expression of FLT1 mRNA18465119
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of FLT1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of FLT1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of FLT1 gene29154799
D014638VanadatesVanadates results in decreased expression of FLT1 mRNA22714537
C025643vinclozolinvinclozolin affects the expression of FLT1 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of FLT1 mRNA23034163
D014750VincristineVincristine results in decreased expression of FLT1 mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of FLT1 mRNA26682919
D014801Vitamin AVitamin A results in decreased expression of FLT1 mRNA17426644
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FLT1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of FLT1 mRNA26272509
D015032ZincZinc deficiency results in decreased expression of FLT1 mRNA18356318
D015032ZincZinc results in increased expression of FLT1 mRNA17074742
D015034Zinc OxideZinc Oxide analog results in decreased expression of FLT1 mRNA27215404
C017803zinc protoporphyrinzinc protoporphyrin inhibits the reaction [Diazoxide inhibits the reaction [Oxygen deficiency results in increased expression of FLT1 protein]]25371888
D019287Zinc SulfateZinc Sulfate results in increased expression of FLT1 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-TAS8248162  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005021vascular endothelial growth factor-activated receptor activity-IDA1312256  9299537  
GO:0005021vascular endothelial growth factor-activated receptor activity-IMP11312102  
GO:0005515protein binding-IPI1312256  7657594  9393862  10543948  12771128  14684734  
16893970  18273061  20660291  23397142  
GO:0005524ATP binding-IEA-  
GO:0019838growth factor binding-IPI1312256  10471394  11513746  12366396  16109918  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0036326VEGF-A-activated receptor activity-IDA8605350  
GO:0036327VEGF-B-activated receptor activity-IDA15952180  
GO:0036332placental growth factor-activated receptor activity-IDA12796773  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0002548monocyte chemotaxis-IDA8605350  18079407  
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway-TAS2158038  
GO:0007275multicellular organism development-IBA21873635  
GO:0008284positive regulation of cell proliferation-TAS10748050  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010863positive regulation of phospholipase C activity-IMP11312102  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IMP14633857  
GO:0016477cell migration-IMP8605350  
GO:0018108peptidyl-tyrosine phosphorylation-IDA9299537  11513746  
GO:0030154cell differentiation-IBA21873635  
GO:0030154cell differentiation-IEA-  
GO:0030335positive regulation of cell migration-IDA8605350  
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway-IDA1312256  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IDA8605350  
GO:0036323vascular endothelial growth factor receptor-1 signaling pathway-IDA15952180  
GO:0038084vascular endothelial growth factor signaling pathway-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043406positive regulation of MAP kinase activity-IDA9299537  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IDA9299537  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IMP11312102  
GO:0045766positive regulation of angiogenesis-IMP14633857  28637396  
GO:0046777protein autophosphorylation-IDA9299537  11513746  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IDA9299537  
GO:0048010vascular endothelial growth factor receptor signaling pathway-IMP11312102  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048514blood vessel morphogenesis-ISS-  
GO:0048598embryonic morphogenesis-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:1905563negative regulation of vascular endothelial cell proliferation-IGI22955733  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-TAS8248162  
GO:0005737cytoplasm-IBA21873635  
GO:0005768endosome-IEA-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA11513746  
GO:0005925focal adhesion-HDA21423176  
GO:0015629actin cytoskeleton-IDA-  
GO:0043235receptor complex-IBA21873635  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa04510Focal adhesion
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194306Neurophilin interactions with VEGF and VEGFRTAS
R-HSA-194313VEGF ligand-receptor interactionsTAS
R-HSA-195399VEGF binds to VEGFR leading to receptor dimerizationTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22373537Using LASSO regression to detect predictive aggregate effects in genetic studies. (2011 Nov 29)Fontanarosa JBBMC Proc
23986360Chronic carbon monoxide inhalation during pregnancy augments uterine artery blood flow and uteroplacental vascular growth in mice. (2013 Oct 15)Venditti CCAm J Physiol Regul Integr Comp Physiol
27186328Genes, environment and gene expression in colon tissue: a pathway approach to determining functionality. (2016)Slattery MLInt J Mol Epidemiol Genet
23592147Effect of Bushen Yiqi Huoxue recipe on placental vasculature in pregnant rats with fetal growth restriction induced by passive smoking. (2013 Apr)Chen ZYJ Huazhong Univ Sci Technolog Med Sci
28719646A synergistic negative effect of gestational smoke-exposure and small litter size on rat placental efficiency, vascularisation and angiogenic factors mRNA expression. (2017)Chen ZYPLoS One
29029509Establishment of oral squamous cell carcinoma cell line and magnetic bead-based isolation and characterization of its CD90/CD44 subpopulations. (2017 Sep 12)Svobodova MOncotarget
26072521A Candidate-Pathway Approach to Identify Gene-Environment Interactions: Analyses of Colon Cancer Risk and Survival. (2015 Sep)Sharafeldin NJ Natl Cancer Inst
23794399VEGFA, FLT1, KDR and colorectal cancer: assessment of disease risk, tumor molecular phenotype, and survival. (2014 Feb)Slattery MLMol Carcinog
22427682Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression. (2012 Sep)Philibert RAJ Leukoc Biol
25524550Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals. (2015 Apr)Horibe HNephrology (Carlton)
20437013Prognostic impact of VEGF and VEGF receptor 1 (FLT1) expression in patients irradiated for stage II/III non-small cell lung cancer (NSCLC). (2010 Jun)Rades DStrahlenther Onkol
25165809Effects of maternal smoking on the placental expression of genes related to angiogenesis and apoptosis during the first trimester. (2014)Kawashima APLoS One