Gene: PLCL2

23228
PLCE2
phospholipase C like 2
protein-coding
3p24.3
Ensembl:ENSG00000154822 MIM:614276 Vega:OTTHUMG00000155467 UniprotKB:Q9UPR0
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.310e-1 (AD)  9.325e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9876768chr3:17008473 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16503724chr3:17130667PLCL21.200e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NBEA0.957
FAXC0.955
MYCBP20.955
FRMPD40.953
ATP8A20.952
GPR1580.949
STXBP5L0.948
DLG30.948
STRBP0.948
LNX10.946

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.574
RAB13-0.566
MYL3-0.561
YES1-0.556
ROM1-0.552
ASB4-0.546
STON2-0.544
CHST14-0.543
RNF135-0.538
TGIF1-0.538

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PLCL2 mRNA28329830
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PLCL2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of PLCL2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLCL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLCL2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PLCL2 mRNA21420995
D020106AcrylamideAcrylamide results in increased expression of PLCL2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PLCL2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PLCL2 mRNA19770486
D001280AtrazineAtrazine results in decreased expression of PLCL2 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of PLCL2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLCL2 mRNA20106945
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PLCL2 mRNA]22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLCL2 mRNA"19150397
C006780bisphenol Abisphenol A results in decreased expression of PLCL2 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of PLCL2 mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PLCL2 mRNA24763279
D002922CiguatoxinsCiguatoxins affects the expression of PLCL2 mRNA18353800
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PLCL2 mRNA20971185
D003300CopperCopper deficiency results in decreased expression of PLCL2 mRNA19821111
D016572CyclosporineCyclosporine results in decreased expression of PLCL2 mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PLCL2 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PLCL2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of PLCL2 mRNA27392435
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PLCL2 mRNA28329830
D005557FormaldehydeFormaldehyde results in decreased expression of PLCL2 mRNA23416264
D005557FormaldehydeFormaldehyde results in increased expression of PLCL2 mRNA23649840
D005839GentamicinsGentamicins results in decreased expression of PLCL2 mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PLCL2 mRNA24763279
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PLCL2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PLCL2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLCL2 mRNA23086925|2530787
D008353MannitolMannitol results in decreased expression of PLCL2 mRNA25270620
D008558MelphalanMelphalan results in decreased expression of PLCL2 mRNA22363485
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLCL2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PLCL2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLCL2 mRNA"25554681
D009532NickelNickel results in increased expression of PLCL2 mRNA24768652
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PLCL2 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PLCL2 mRNA25729387
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PLCL2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of PLCL2 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLCL2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PLCL2 mRNA26272509
D016226Phosphorus, Dietary"Phosphorus, Dietary affects the expression of PLCL2 mRNA"17651324
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLCL2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PLCL2 mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of PLCL2 mRNA]17950772
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PLCL2 mRNA22714537
D015474IsotretinoinIsotretinoin results in increased expression of PLCL2 mRNA20436886
C009495titanium dioxidetitanium dioxide results in decreased expression of PLCL2 mRNA23409001
C009495titanium dioxidetitanium dioxide results in increased expression of PLCL2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PLCL2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PLCL2 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of PLCL2 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of PLCL2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PLCL2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of PLCL2 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PLCL2 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of PLCL2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004435phosphatidylinositol phospholipase C activity-IEA-  
GO:0050811GABA receptor binding-IDA16754670  
GO:0070679inositol 1,4,5 trisphosphate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002322B cell proliferation involved in immune response-IEA-  
GO:0002337B-1a B cell differentiation-IEA-  
GO:0006629lipid metabolic process-IEA-  
GO:0007214gamma-aminobutyric acid signaling pathway-IEA-  
GO:0032228regulation of synaptic transmission, GABAergic-IEA-  
GO:0033135regulation of peptidyl-serine phosphorylation-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0050859negative regulation of B cell receptor signaling pathway-IEA-  
GO:1900122positive regulation of receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal