Gene: PHLPP1

23239
PHLPP|PLEKHE1|PPM3A|SCOP
PH domain and leucine rich repeat protein phosphatase 1
protein-coding
18q21.33
Ensembl:ENSG00000081913 MIM:609396 Vega:OTTHUMG00000150629 UniprotKB:O60346
NG_031923.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.246e-1 (AD)  1.489e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7235367chr18:62942490 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPRC5B0.919
PLXNB10.876
MEGF100.872
FGFR20.865
LLGL10.861
NEO10.854
CDH200.852
PAQR80.85
FAXDC20.849
AMER20.848

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.524
OR4F29-0.503
SCARA5-0.347
FER1L6-0.323
CD163L1-0.307
TWIST2-0.303
BMP5-0.299
GADL1-0.297
PNOC-0.296
LBH-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PHLPP1 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PHLPP1 mRNA"28973690
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PHLPP1 gene27153756
C050510arsenic trichloride[arsenic trichloride results in increased expression of MIR190A] promotes the reaction [[MIR190A binds to PHLPP1 3' UTR] which results in decreased expression of PHLPP1 protein]21750348|2175034
C050510arsenic trichloride[arsenic trichloride results in increased expression of MIR190A] which results in decreased expression of PHLPP1 protein21750348
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PHLPP1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PHLPP1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHLPP1 mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PHLPP1 mRNA27858113
C006780bisphenol Abisphenol A results in decreased expression of PHLPP1 mRNA26063408
C006780bisphenol Abisphenol A results in increased methylation of PHLPP1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of PHLPP1 mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PHLPP1 mRNA27858113
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of PHLPP1 mRNA16197558
D019327Copper SulfateCopper Sulfate results in decreased expression of PHLPP1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PHLPP1 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PHLPP1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PHLPP1 mRNA27392435
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHLPP1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PHLPP1 mRNA27392435
D008694MethamphetamineMethamphetamine affects the expression of PHLPP1 mRNA15950759
D008694MethamphetamineMethamphetamine results in increased expression of PHLPP1 protein15542705|1595075
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PHLPP1 mRNA"25554681
C016030pantogabpantogab results in decreased expression of PHLPP1 mRNA17379144
C115711PD 173074PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK1 protein]25953896
C115711PD 173074PD 173074 inhibits the reaction [PHLPP1 gene mutant form results in increased phosphorylation of MAPK3 protein]25953896
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PHLPP1 mRNA21334430
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PHLPP1 protein23718831
D012822Silicon DioxideSilicon Dioxide results in increased expression of PHLPP1 mRNA25351596
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHLPP1 mRNA24680724
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PHLPP1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHLPP1 mRNA25613284
C057693troglitazonetroglitazone results in decreased expression of PHLPP1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of PHLPP1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of PHLPP1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PHLPP1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004722protein serine/threonine phosphatase activity-IBA21873635  
GO:0005515protein binding-IPI18162466  19615732  21701506  21804599  24145035  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002667regulation of T cell anergy-IEA-  
GO:0006470protein dephosphorylation-IBA21873635  
GO:0006470protein dephosphorylation-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0009649entrainment of circadian clock-IEA-  
GO:0042981regulation of apoptotic process-IDA20513427  
GO:0043408regulation of MAPK cascade-IMP24530606  
GO:0046328regulation of JNK cascade-IBA21873635  
GO:0046328regulation of JNK cascade-IDA17386267  
GO:0051896regulation of protein kinase B signaling-IBA21873635  
GO:0051898negative regulation of protein kinase B signaling-IMP17386267  
GO:0090036regulation of protein kinase C signaling-IBA21873635  
GO:1900744regulation of p38MAPK cascade-IBA21873635  
GO:1900744regulation of p38MAPK cascade-IDA17386267  
GO ID GO Term Qualifier Evidence PubMed
GO:0001917photoreceptor inner segment-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0031965nuclear membrane-IBA21873635  
GO:0042622photoreceptor outer segment membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal