Gene: ANKS1A

23294
ANKS1
ankyrin repeat and sterile alpha motif domain containing 1A
protein-coding
6p21.31
Ensembl:ENSG00000064999 MIM:608994 Vega:OTTHUMG00000014559 UniprotKB:Q92625
NC_000006.12
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.417e-1 (AD)  8.629e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2140418chr6:35007638 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs847848chr6:34938391 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs847851chr6:34936807 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs1737727chr6:34936711 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg07254055chr6:35011768ANKS1AGene body1.275e-4Alcohol use disorders26763658
cg04739880chr6:35017865ANKS1A7.000e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRRM20.878
GGA20.86
CTC10.856
UNC13B0.855
TSC10.85
PRPF80.849
FAM160B20.847
MCM3AP0.847
INTS30.846
MTHFR0.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.595
OR4F29-0.57
LHX5-0.322
HMX2-0.319
FOXB1-0.319
SIM1-0.317
HCRT-0.315
OXT-0.315
C5orf38-0.311
OTP-0.31

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to ANKS1A protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ANKS1A protein]26598702
D000082AcetaminophenAcetaminophen results in increased expression of ANKS1A mRNA22230336
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ANKS1A mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to ANKS1A protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ANKS1A mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANKS1A mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of ANKS1A mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKS1A mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ANKS1A mRNA25181051
D003561CytarabineCytarabine results in decreased expression of ANKS1A mRNA21198554
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKS1A mRNA28628672
D002945CisplatinCisplatin results in decreased expression of ANKS1A mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of ANKS1A mRNA28302478
C024629dimethyl phthalatedimethyl phthalate affects the expression of ANKS1A mRNA26924002
D004237DiuronDiuron results in decreased expression of ANKS1A mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ANKS1A protein23301498
C069837fullerene C60fullerene C60 results in increased expression of ANKS1A mRNA19167457
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ANKS1A mRNA21179406
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKS1A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKS1A mRNA28628672
C028007nickel monoxidenickel monoxide results in increased expression of ANKS1A mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ANKS1A mRNA25729387
D011441PropylthiouracilPropylthiouracil results in increased expression of ANKS1A mRNA24780913
D012999SomanSoman results in increased expression of ANKS1A mRNA19281266
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ANKS1A mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ANKS1A mRNA25729387

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15324660  16273093  17353931  24658140  
GO:0046875ephrin receptor binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006929substrate-dependent cell migration-ISS-  
GO:0016322neuron remodeling-ISS-  
GO:0048013ephrin receptor signaling pathway-ISS-  
GO:1901187regulation of ephrin receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0043005neuron projection-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21529783A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (2011 Sep 15)Heath ACBiol Psychiatry
23144319Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (2013 Feb)Lee YCarcinogenesis