Gene: BICD2

23299
SMALED2|bA526D8.1
BICD cargo adaptor 2
protein-coding
9q22.31
Ensembl:ENSG00000185963 MIM:609797 Vega:OTTHUMG00000021036 UniprotKB:Q8TD16
NG_033908.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.163e-1 (AD)  9.231e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10821008chr9:92725215 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XPO70.944
ATP2A20.936
KPNA60.936
MECP20.932
SLC35E10.932
UBE3C0.931
RALGAPB0.931
MBD10.93
FAM53C0.928
PHF200.925

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.589
OR4F29-0.533
MYL3-0.352
CTNNA3-0.343
CSAG1-0.326
SH2D1A-0.32
COPZ2-0.319
KLRC2-0.313
MTRNR2L6-0.308
KLRB1-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of BICD2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of BICD2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of BICD2 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of BICD2 mRNA25064622
D000082AcetaminophenAcetaminophen results in increased expression of BICD2 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of BICD2 mRNA28959563
D000638AmiodaroneAmiodarone affects the expression of BICD2 mRNA25064622
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BICD2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BICD2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of BICD2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of BICD2 mRNA"19150397|2001819
D004958EstradiolEstradiol affects the expression of BICD2 mRNA22574217
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of BICD2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of BICD2 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of BICD2 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of BICD2 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in increased expression of BICD2 mRNA26472689
D002122Calcium ChlorideCalcium Chloride results in increased expression of BICD2 protein25824407
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of BICD2 mRNA17484886
D002746ChlorpromazineChlorpromazine affects the expression of BICD2 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of BICD2 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of BICD2 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BICD2 mRNA21266533
C000944dicrotophosdicrotophos results in increased expression of BICD2 mRNA28302478
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of BICD2 mRNA"22485181
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BICD2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BICD2 mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of BICD2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of BICD2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BICD2 mRNA17942748
C010974glyphosateglyphosate results in decreased expression of BICD2 mRNA25636363
D017313FenretinideFenretinide results in decreased expression of BICD2 mRNA28973697
C045463leflunomideleflunomide results in decreased expression of BICD2 mRNA28988120
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of BICD2 mRNA"20188158
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of BICD2 mRNA25380136
D010269ParaquatParaquat affects the expression of BICD2 mRNA25064622
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of BICD2 mRNA28973697
C006253pirinixic acidpirinixic acid results in increased expression of BICD2 mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of BICD2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of BICD2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of BICD2 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of BICD2 mRNA24780913
D013629TamoxifenTamoxifen affects the expression of BICD2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BICD2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of BICD2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BICD2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BICD2 mRNA19684285
D013752TetracyclineTetracycline affects the expression of BICD2 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of BICD2 mRNA25064622
D013853ThioacetamideThioacetamide results in increased expression of BICD2 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of BICD2 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of BICD2 mRNA23409001
C483909torcetrapibtorcetrapib results in increased expression of BICD2 mRNA23228038
D014635Valproic AcidValproic Acid affects the expression of BICD2 mRNA25064622
D014635Valproic AcidValproic Acid affects the expression of BICD2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of BICD2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of BICD2 gene29154799
D014810Vitamin EVitamin E results in decreased expression of BICD2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16417406  20386726  23664119  24482476  
GO:0008093cytoskeletal adaptor activity-IEA-  
GO:0017137Rab GTPase binding-ISS-  
GO:0034452dynactin binding-ISS-  
GO:0051959dynein light intermediate chain binding-IEA-  
GO:0070840dynein complex binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006890retrograde vesicle-mediated transport, Golgi to ER-IMP25962623  
GO:0015031protein transport-IEA-  
GO:0034067protein localization to Golgi apparatus-IMP25962623  
GO:0051028mRNA transport-IEA-  
GO:0051642centrosome localization-IMP20386726  
GO:0070507regulation of microtubule cytoskeleton organization-IGI17139249  
GO:0072385minus-end-directed organelle transport along microtubule-ISS-  
GO:0072393microtubule anchoring at microtubule organizing center-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005635nuclear envelope-IDA20386726  
GO:0005642annulate lamellae-IDA20386726  
GO:0005643nuclear pore-IDA20386726  
GO:0005737cytoplasm-IMP17139249  
GO:0005794Golgi apparatus-IDA-  
GO:0005813centrosome-IMP17139249  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0031410cytoplasmic vesicle-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-6811436COPI-independent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal