Gene: EHBP1

23301
HPC12|NACSIN
EH domain binding protein 1
protein-coding
2p15
Ensembl:ENSG00000115504 MIM:609922 Vega:OTTHUMG00000129453 UniprotKB:Q8NDI1
NG_016758.1
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.232e-1 (AD)  9.087e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1877026chr2:62845073 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12395259chr2:63271927EHBP1Gene body2.711e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CAB390.936
ACTR20.932
SHOC20.926
UBA50.918
SPIN10.918
DENR0.917
RAP2A0.916
BLOC1S60.915
PJA20.915
CNOT70.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.583
OR4F29-0.569
EYA2-0.362
C22orf31-0.354
OLAH-0.342
CYP11A1-0.338
GPR143-0.333
NXNL1-0.325
TPPP2-0.325
S100A1-0.322

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EHBP1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EHBP1 mRNA"20959002
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EHBP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EHBP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of EHBP1 mRNA21420995|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EHBP1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EHBP1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EHBP1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EHBP1 mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of EHBP1 mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EHBP1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EHBP1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of EHBP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EHBP1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EHBP1 mRNA26238291
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EHBP1 mRNA27858113
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of EHBP1 mRNA"19150397|2001819
D004958EstradiolEstradiol affects the expression of EHBP1 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of EHBP1 mRNA20660070
C044887beta-methylcholinebeta-methylcholine affects the expression of EHBP1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EHBP1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of EHBP1 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of EHBP1 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of EHBP1 mRNA24136188
C018475butyraldehydebutyraldehyde results in decreased expression of EHBP1 mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of EHBP1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in decreased expression of EHBP1 mRNA19376846
D016572CyclosporineCyclosporine results in decreased expression of EHBP1 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of EHBP1 mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of EHBP1 mRNA24921660
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EHBP1 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of EHBP1 mRNA19561079|2739243
D002117CalcitriolCalcitriol results in increased expression of EHBP1 mRNA16002434
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of EHBP1 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EHBP1 mRNA22079256
D005557FormaldehydeFormaldehyde results in decreased expression of EHBP1 mRNA23649840
C001277geldanamycingeldanamycin results in increased expression of EHBP1 mRNA26705709
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of EHBP1 mRNA22634610
C010974glyphosateglyphosate results in decreased expression of EHBP1 mRNA16532367
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EHBP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of EHBP1 mRNA28628672
C410337K 7174K 7174 results in increased expression of EHBP1 mRNA24086573
D007854LeadLead affects the splicing of EHBP1 mRNA28903495
C045463leflunomideleflunomide results in increased expression of EHBP1 mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of EHBP1 mRNA"24972896
D008294MalathionEHBP1 gene SNP results in increased susceptibility to Malathion23593118
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of EHBP1 mRNA27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EHBP1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EHBP1 mRNA23649840
D009151Mustard GasMustard Gas affects the expression of EHBP1 mRNA15651846
C051752nefazodonenefazodone results in decreased expression of EHBP1 mRNA24136188
D009532NickelNickel results in decreased expression of EHBP1 mRNA25583101
C012655nimesulidenimesulide results in decreased expression of EHBP1 mRNA24136188
D010416PentachlorophenolPentachlorophenol results in increased expression of EHBP1 mRNA24642059
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of EHBP1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of EHBP1 mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of EHBP1 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EHBP1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EHBP1 mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of EHBP1 mRNA20660070
D011794QuercetinQuercetin results in decreased expression of EHBP1 mRNA21632981
D012643SeleniumSelenium results in decreased expression of EHBP1 mRNA19244175
C017947sodium arsenitesodium arsenite affects the methylation of EHBP1 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of EHBP1 mRNA19072884
D012999SomanSoman results in decreased expression of EHBP1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EHBP1 mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of EHBP1 mRNA25975270
D013849ThimerosalThimerosal results in decreased expression of EHBP1 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of EHBP1 mRNA23557971
C483909torcetrapibtorcetrapib results in increased expression of EHBP1 mRNA23228038
D014212TretinoinTretinoin results in decreased expression of EHBP1 mRNA21934132
D014212TretinoinTretinoin results in decreased expression of EHBP1 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EHBP1 mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of EHBP1 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of EHBP1 mRNA26272509
C057693troglitazonetroglitazone results in decreased expression of EHBP1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of EHBP1 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in decreased methylation of EHBP1 gene29154799
D014810Vitamin EVitamin E results in decreased expression of EHBP1 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of EHBP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-IEA-  
GO:0015031protein transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005768endosome-IEA-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal