Gene: DMXL2

23312
DFNA71|PEPNS|RC3
Dmx like 2
protein-coding
15q21.2
Ensembl:ENSG00000104093 MIM:612186 Vega:OTTHUMG00000131749 UniprotKB:Q8TDJ6
NG_017155.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.291e-1 (AD)  3.558e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6493511chr15:51609408 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14296394chr15:51910925DMXL2Gene body6.295e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNJ10.969
NBEA0.965
MTMR90.962
SLC35B40.962
KIF3A0.961
GSK3B0.961
MYCBP20.96
RNMT0.958
WDR70.956
ATP6V1A0.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.56
HEY2-0.526
RAB13-0.522
ROM1-0.505
RAI14-0.488
RNF135-0.484
CNN2-0.478
YES1-0.477
MYL3-0.474
COPZ2-0.474

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DMXL2 mRNA"19114083
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of DMXL2 mRNA"20816883
D000082AcetaminophenAcetaminophen results in decreased expression of DMXL2 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of DMXL2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of DMXL2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DMXL2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of DMXL2 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of DMXL2 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of DMXL2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DMXL2 mRNA21839799
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DMXL2 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of DMXL2 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of DMXL2 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of DMXL2 mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of DMXL2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of DMXL2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of DMXL2 mRNA26079696
D003471CuprizoneCuprizone results in decreased expression of DMXL2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DMXL2 mRNA25562108
D002945CisplatinCisplatin results in increased expression of DMXL2 mRNA27594783
D004041Dietary FatsDietary Fats results in increased expression of DMXL2 mRNA19030233
D004041Dietary FatsDietary Fats results in increased expression of DMXL2 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of DMXL2 mRNA]21852083
D004237DiuronDiuron results in decreased expression of DMXL2 mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DMXL2 mRNA22079256
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of DMXL2 mRNA22634610
C016517indole-3-carbinolindole-3-carbinol affects the expression of DMXL2 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DMXL2 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of DMXL2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of DMXL2 mRNA24796395
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of DMXL2 mRNA"24972896
D008627Mercuric ChlorideMercuric Chloride affects the expression of DMXL2 mRNA20353558
D008727MethotrexateMethotrexate results in increased expression of DMXL2 mRNA17400583
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of DMXL2 protein25809596
D009532NickelNickel results in decreased expression of DMXL2 mRNA23195993
C028007nickel monoxidenickel monoxide affects the expression of DMXL2 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of DMXL2 mRNA25729387
D010936Plant ExtractsPlant Extracts results in increased expression of DMXL2 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DMXL2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DMXL2 mRNA22079256|2271453
D011192Potassium DichromatePotassium Dichromate results in increased expression of DMXL2 mRNA23608068
D011794QuercetinQuercetin results in decreased expression of DMXL2 mRNA21632981
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of DMXL2 mRNA]21852083
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of DMXL2 mRNA21427059
D012643SeleniumSelenium results in decreased expression of DMXL2 mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of DMXL2 mRNA21795629
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of DMXL2 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DMXL2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DMXL2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DMXL2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of DMXL2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of DMXL2 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of DMXL2 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of DMXL2 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of DMXL2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DMXL2 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of DMXL2 mRNA19136453|2142705

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0017137Rab GTPase binding-IDA11809763  
GO ID GO Term Qualifier Evidence PubMed
GO:0007035vacuolar acidification-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA22664934  
GO:0008021synaptic vesicle-IDA11809763  
GO:0030054cell junction-IEA-  
GO:0030672synaptic vesicle membrane-IEA-  
GO:0043291RAVE complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal