Gene: SLC9A8

23315
NHE-8|NHE8
solute carrier family 9 member A8
protein-coding
20q13.13
Ensembl:ENSG00000197818 MIM:612730 Vega:OTTHUMG00000032710 UniprotKB:Q9Y2E8
NC_000020.11
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.075e-1 (AD)  4.462e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2281223chr20:49867704 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs17786105chr20:49850348 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4809760chr20:49838134 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs8118160chr20:49818099 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VPS520.887
NDST20.876
FAM160A20.873
NAT100.866
TOP3A0.863
GBF10.862
ZZEF10.862
LRRC410.862
CLEC16A0.859
CHD80.858

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.541
OR4F29-0.497
MTRNR2L6-0.38
MTRNR2L9-0.371
MTRNR2L10-0.333
KLRC2-0.327
PPBP-0.303
OR4F16-0.282
TMSB15A-0.282
SH2D1A-0.28

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of SLC9A8 mRNA"19114083
C1189563-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride3-(2-(3-guanidino-2-methyl-3-oxo-propenyl)-5-methylphenyl)-N-isopropylidene-2-methyl-acrylamide dihydrochloride results in decreased activity of SLC9A8 protein18209477
C4879483-iodothyronamineSLC9A8 mRNA affects the uptake of 3-iodothyronamine19074582
C0741073-methylsulfonyl-4-piperidinobenzoyl guanidine3-methylsulfonyl-4-piperidinobenzoyl guanidine results in decreased activity of SLC9A8 protein18209477
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of SLC9A8 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC9A8 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SLC9A8 mRNA24449571
C547126AZM551248AZM551248 results in decreased expression of SLC9A8 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of SLC9A8 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of SLC9A8 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SLC9A8 gene28505145
D002104CadmiumCadmium results in increased expression of SLC9A8 mRNA24376830
D016572CyclosporineCyclosporine results in increased expression of SLC9A8 mRNA27989131
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SLC9A8 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of SLC9A8 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of SLC9A8 mRNA25016146
D004147DioxinsDioxins affects the expression of SLC9A8 mRNA20463971
C069837fullerene C60fullerene C60 results in decreased expression of SLC9A8 mRNA19167457
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to SLC9A8 gene]20091679
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SLC9A8 mRNA27392435
D008694MethamphetamineMethamphetamine results in increased expression of SLC9A8 mRNA26307267
D008727MethotrexateMethotrexate results in decreased expression of SLC9A8 mRNA24449571
C028007nickel monoxidenickel monoxide results in decreased expression of SLC9A8 mRNA19167457
C025589ochratoxin Aochratoxin A results in increased acetylation of SLC9A8 promoter29098329
C006253pirinixic acidpirinixic acid results in increased expression of SLC9A8 mRNA18301758
D011794QuercetinQuercetin results in increased expression of SLC9A8 mRNA21632981
D012293RifampinRifampin results in increased expression of SLC9A8 mRNA27199754
D013739TestosteroneTestosterone results in decreased expression of SLC9A8 mRNA21669218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC9A8 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC9A8 mRNA18087596
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of SLC9A8 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC9A8 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of SLC9A8 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of SLC9A8 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of SLC9A8 mRNA17292431
D014640VancomycinVancomycin results in increased expression of SLC9A8 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SLC9A8 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of SLC9A8 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of SLC9A8 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0015385sodium:proton antiporter activity-IBA21873635  
GO:0015385sodium:proton antiporter activity-TAS-  
GO:0015386potassium:proton antiporter activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-TAS-  
GO:0051453regulation of intracellular pH-IBA21873635  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0098719sodium ion import across plasma membrane-IBA21873635  
GO:1902600proton transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-382551Transport of small moleculesTAS
R-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptidesTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425986Sodium/Proton exchangersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28816579Application of the distance-based F test in an mGWAS investigating beta diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci. (2018 Jan 2)Ruhlemann MCGut Microbes