Gene: WDR7

23335
TRAG
WD repeat domain 7
protein-coding
18q21.31
Ensembl:ENSG00000091157 MIM:613473 Vega:OTTHUMG00000132721 UniprotKB:Q9Y4E6
NC_000018.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.456e-1 (AD)  8.258e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17750015chr18:56730391 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNJ10.981
CADPS0.977
TMEM2460.977
NELL20.976
MAP2K40.974
GLRB0.973
ATP6V1A0.973
SNAP910.972
WDR470.972
NSF0.972

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.539
RNF135-0.524
HEY2-0.517
YES1-0.501
RAI14-0.501
REST-0.499
RAB13-0.492
FZD10-0.492
COPZ2-0.489
ASB4-0.489

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of WDR7 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of WDR7 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 affects the expression of WDR7 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of WDR7 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of WDR7 mRNA16483693
C006632arsenic trioxideWDR7 protein results in increased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in increased expression of WDR7 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of WDR7 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of WDR7 mRNA20064835|2010694
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of WDR7 mRNA"19150397|2038263
C006780bisphenol Abisphenol A results in decreased expression of WDR7 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of WDR7 gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of WDR7 mRNA25596134
C004656chloroacetaldehydechloroacetaldehyde results in decreased expression of WDR7 mRNA25596134
D019327Copper SulfateCopper Sulfate results in decreased expression of WDR7 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of WDR7 mRNA25596134
D003976DiazinonDiazinon results in increased methylation of WDR7 gene22964155
D004041Dietary FatsDietary Fats results in decreased expression of WDR7 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in decreased expression of WDR7 mRNA]19030233
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of WDR7 mRNA22079256
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of WDR7 mRNA22634610
C412815GW 4064GW 4064 results in decreased expression of WDR7 mRNA26655953
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of WDR7 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of WDR7 mRNA24796395
D048628KetolidesKetolides analog results in increased expression of WDR7 mRNA24967691
C008261lead acetatelead acetate affects the expression of WDR7 mRNA21147602
C002385linsidominelinsidomine results in increased oxidation of WDR7 protein28086193
D010100OxygenOxygen deficiency results in decreased expression of WDR7 mRNA25596134
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of WDR7 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of WDR7 mRNA22079256|2271453
D011794QuercetinQuercetin results in decreased expression of WDR7 mRNA21632981
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in decreased expression of WDR7 mRNA]19030233
C089730rosiglitazonerosiglitazone results in decreased expression of WDR7 mRNA25596134
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of WDR7 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of WDR7 protein24648495
D014520UrethaneUrethane results in increased expression of WDR7 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of WDR7 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008021synaptic vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal