Gene: MLYCD

23417
MCD
malonyl-CoA decarboxylase
protein-coding
16q23.3
Ensembl:ENSG00000103150 MIM:606761 Vega:OTTHUMG00000176654 UniprotKB:O95822
NG_009079.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.714e-1 (AD)  7.137e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3809622chr16:83897933 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMPD10.829
FUZ0.824
KEAP10.822
ZFYVE190.821
CYHR10.817
COG40.816
ILVBL0.816
SCAP0.811
FAM171A10.808
YIF1B0.807

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.591
OR4F29-0.539
CLEC6A-0.445
IL18RAP-0.418
CXorf65-0.415
GSDMA-0.402
CLEC12A-0.395
GADL1-0.388
DPPA4-0.379
TRIM10-0.375

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MLYCD mRNA"19114083
C5201644-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased expression of MLYCD mRNA15721863
D000082AcetaminophenAcetaminophen affects the expression of MLYCD mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of MLYCD mRNA24489787
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MLYCD mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MLYCD mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of MLYCD mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of MLYCD mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MLYCD mRNA16644059
C018021cobaltous chloridecobaltous chloride results in decreased expression of MLYCD mRNA11549245
D003300CopperCopper results in decreased expression of MLYCD mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of MLYCD mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of MLYCD mRNA20106945|2556210
D004041Dietary FatsDietary Fats results in increased expression of MLYCD mRNA18042831
D004317DoxorubicinDoxorubicin results in decreased expression of MLYCD mRNA26873546
D011345Fenofibrate[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]26973390
D011345FenofibrateFenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]26973390
D011345FenofibrateFenofibrate promotes the reaction [PPARA protein results in increased expression of MLYCD mRNA]14641110
D018120FinasterideFinasteride results in increased expression of MLYCD mRNA24136188
D005632Fructose[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]26973390
D005632FructoseFenofibrate inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]26973390
D005632FructoseFructose results in decreased expression of MLYCD mRNA26973390
D005632Fructoseresveratrol inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]26973390
D007213IndomethacinIndomethacin results in increased expression of MLYCD mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MLYCD mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MLYCD mRNA24796395
C045463leflunomideleflunomide results in decreased expression of MLYCD mRNA28988120
C045463leflunomideleflunomide results in increased expression of MLYCD mRNA24136188
D008316Malonyl Coenzyme APPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A]14641110
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MLYCD mRNA28001369
C500085muraglitazarmuraglitazar results in increased expression of MLYCD mRNA21515302
C051752nefazodonenefazodone results in increased expression of MLYCD mRNA24136188
C012655nimesulidenimesulide results in increased expression of MLYCD mRNA24136188
D010100OxygenOxygen deficiency results in decreased expression of MLYCD mRNA24205000
D000073878Palm OilPalm Oil results in increased expression of MLYCD mRNA18042831
C016030pantogabpantogab results in increased expression of MLYCD mRNA17379144
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MLYCD mRNA17681415
D010634PhenobarbitalPhenobarbital affects the expression of MLYCD mRNA19159669
C006253pirinixic acidpirinixic acid results in increased expression of MLYCD mRNA17426115|1795077
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of MLYCD mRNA]17950772
C006253pirinixic acidpirinixic acid promotes the reaction [PPARA protein results in increased expression of MLYCD mRNA]14641110
D017035PravastatinPravastatin results in decreased expression of MLYCD mRNA27225895
D017035PravastatinPravastatin affects the expression of MLYCD mRNA27225895
C059514resveratrol[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]26973390
C059514resveratrolresveratrol inhibits the reaction [Fructose results in decreased expression of MLYCD mRNA]26973390
C089730rosiglitazonerosiglitazone affects the expression of MLYCD mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of MLYCD mRNA21515302
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MLYCD mRNA21427059
C009277sodium arsenatesodium arsenate affects the methylation of MLYCD promoter20667999
C009277sodium arsenatesodium arsenate results in increased expression of MLYCD mRNA20667999
C075117squalestatin 1squalestatin 1 affects the expression of MLYCD mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of MLYCD mRNA27225895
C501413tesaglitazartesaglitazar results in increased expression of MLYCD mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MLYCD gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MLYCD mRNA21354282|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MLYCD mRNA18796159
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MLYCD mRNA25613284
D014303TrinitrotolueneTrinitrotoluene affects the expression of MLYCD mRNA21346803
C057693troglitazonetroglitazone results in increased expression of MLYCD mRNA21515302
D014520UrethaneUrethane results in decreased expression of MLYCD mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MLYCD mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of MLYCD mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of MLYCD mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI20178365  
GO:0042802identical protein binding-IPI23791943  
GO:0050080malonyl-CoA decarboxylase activity-IDA9869665  10417274  10455107  15003260  
GO:0050080malonyl-CoA decarboxylase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002931response to ischemia-ISS-  
GO:0006085acetyl-CoA biosynthetic process-IDA9869665  10417274  10455107  
GO:0006085acetyl-CoA biosynthetic process-IEA-  
GO:0006625protein targeting to peroxisome-TAS-  
GO:0006633fatty acid biosynthetic process-IDA15003260  
GO:0006637acyl-CoA metabolic process-TAS-  
GO:0010906regulation of glucose metabolic process-IMP18314420  
GO:0046321positive regulation of fatty acid oxidation-IMP18314420  
GO:2001294malonyl-CoA catabolic process-IDA10417274  10455107  15003260  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA10455107  
GO:0005739mitochondrion-IDA10417274  
GO:0005759mitochondrial matrix-ISS-  
GO:0005777peroxisome-IDA10417274  10455107  
GO:0005782peroxisomal matrix-ISS-  
GO:0005782peroxisomal matrix-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00410beta-Alanine metabolism
hsa00640Propanoate metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-390247Beta-oxidation of very long chain fatty acidsTAS
R-HSA-390918Peroxisomal lipid metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-556833Metabolism of lipidsTAS
R-HSA-8978868Fatty acid metabolismTAS
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033241Peroxisomal protein importIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal