Gene: PHF3

23469
-
PHD finger protein 3
protein-coding
6q12
Ensembl:ENSG00000118482 MIM:607789 Vega:OTTHUMG00000014952 UniprotKB:Q92576
NG_034034.1
PubMed|SNP Mapped
3   ANCO-SNPs
AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.082e-1 (AD)  2.661e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10755432chr6:63687952 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10485358chr6:63676159 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6932538chr6:63673079 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMC30.886
CPSF20.878
NIPBL0.872
ANKIB10.872
RSF10.867
NBR10.865
SAMD80.864
TPR0.864
SGCB0.863
SMARCA50.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.624
OR4F5-0.604
TNFRSF18-0.202
PTGDR2-0.187
PRTN3-0.185
SHISA8-0.176
PRSS56-0.175
CRH-0.17
MUC12-0.168
NANOGNB-0.168

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PHF3 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of PHF3 mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF3 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHF3 mRNA19770486
D006710HomocysteineHomocysteine results in decreased expression of PHF3 mRNA17326132
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PHF3 mRNA"19150397|2623829
C006780bisphenol Abisphenol A results in increased expression of PHF3 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PHF3 mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of PHF3 mRNA25181051
D003010ClorgylineClorgyline results in increased expression of PHF3 mRNA19691856
C018021cobaltous chloridecobaltous chloride results in increased expression of PHF3 mRNA24386269
D016572CyclosporineCyclosporine affects the expression of PHF3 mRNA19770486
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PHF3 protein23301498
D018120FinasterideFinasteride results in increased expression of PHF3 mRNA24136188
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PHF3 mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of PHF3 mRNA20003209
C410337K 7174K 7174 results in increased expression of PHF3 mRNA24086573
C045463leflunomideleflunomide results in increased expression of PHF3 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PHF3 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PHF3 mRNA26378955
D008558MelphalanMelphalan results in decreased expression of PHF3 mRNA22363485
D008627Mercuric ChlorideMercuric Chloride affects the expression of PHF3 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PHF3 mRNA23103053
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PHF3 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PHF3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PHF3 mRNA"25554681
D009538NicotineNicotine results in increased expression of PHF3 mRNA16949557
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PHF3 mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of PHF3 mRNA19159669
D010936Plant ExtractsPlant Extracts results in increased expression of PHF3 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of PHF3 mRNA23012394
D012402RotenoneRotenone results in increased expression of PHF3 mRNA19013527
D012643SeleniumSelenium results in decreased expression of PHF3 mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of PHF3 mRNA29191790
D012969Sodium FluorideSodium Fluoride results in decreased expression of PHF3 mRNA27862939
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PHF3 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PHF3 mRNA26378955
C004648testosterone enanthatetestosterone enanthate affects the expression of PHF3 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PHF3 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PHF3 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of PHF3 mRNA23557971
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF3 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PHF3 mRNA26272509
C012589trichostatin Atrichostatin A results in increased expression of PHF3 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PHF3 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PHF3 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of PHF3 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of PHF3 mRNA17963808
D014810Vitamin EVitamin E results in decreased expression of PHF3 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-NAS11856869  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25991709Identification of candidate genes that underlie the QTL on chromosome 1 that mediates genetic differences in stress-ethanol interactions. (2015 Aug)Cook MNPhysiol Genomics
24961364Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence. (2014 Jul-Aug)Zuo LAm J Addict
22096494A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study. (2011)Zuo LPLoS One
23324950Association of rare PTP4A1-PHF3-EYS variants with alcohol dependence. (2013 Mar)Zuo LJ Hum Genet
26173551A New Genomewide Association Meta-Analysis of Alcohol Dependence. (2015 Aug)Zuo LAlcohol Clin Exp Res