Gene: SEZ6L

23544
-
seizure related 6 homolog like
protein-coding
22q12.1
Ensembl:ENSG00000100095 MIM:607021 Vega:OTTHUMG00000150870 UniprotKB:Q9BYH1
NG_054877.1
PubMed|SNP Mapped
2   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.641e-1 (AD)  2.357e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs667577chr22:26378614 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6519647chr22:26317998 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OPCML0.938
CA100.927
ENC10.926
ATCAY0.926
EHD30.922
GABBR20.922
NOVA10.921
DCAF60.918
SNAP910.918
ATP6V1C10.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.548
OR4F29-0.482
HEY2-0.436
RHOD-0.433
RAI14-0.424
SNHG18-0.42
LRAT-0.419
CSAG1-0.418
REST-0.415
ARHGEF5-0.411

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEZ6L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEZ6L mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of SEZ6L mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SEZ6L gene27153756
D001280AtrazineAtrazine results in increased expression of SEZ6L mRNA22378314
D001280AtrazineAtrazine results in increased expression of SEZ6L mRNA22982499
C547126AZM551248AZM551248 results in decreased expression of SEZ6L mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of SEZ6L mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of SEZ6L gene28505145
C018021cobaltous chloridecobaltous chloride results in decreased expression of SEZ6L mRNA17553155
D003042CocaineCocaine results in decreased expression of SEZ6L mRNA18355967
D003042CocaineFOS protein mutant form inhibits the reaction [Cocaine results in decreased expression of SEZ6L mRNA]18355967
D004041Dietary FatsDietary Fats results in increased expression of SEZ6L mRNA25016146
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of SEZ6L mRNA]15016801
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SEZ6L mRNA25613284
D007854LeadLead affects the splicing of SEZ6L mRNA28903495
C568376MT19c compoundMT19c compound results in decreased expression of SEZ6L mRNA21781307
D009532NickelNickel results in decreased expression of SEZ6L mRNA24768652|2558310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SEZ6L mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of SEZ6L mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in decreased expression of SEZ6L mRNA23608068
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SEZ6L mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of SEZ6L gene28589171
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SEZ6L mRNA25613284
D014212TretinoinTretinoin results in increased expression of SEZ6L mRNA21934132|2372400
D014635Valproic AcidValproic Acid results in increased expression of SEZ6L mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SEZ6L gene25560391
C111237vorinostatvorinostat results in decreased expression of SEZ6L mRNA27188386
D015032ZincZinc deficiency results in decreased expression of SEZ6L mRNA18356318
D015034Zinc OxideZinc Oxide analog results in decreased expression of SEZ6L mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0008344adult locomotory behavior-IEA-  
GO:0021680cerebellar Purkinje cell layer development-IEA-  
GO:0060074synapse maturation-IEA-  
GO:0090036regulation of protein kinase C signaling-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17804757Seizure 6-like (SEZ6L) gene and risk for lung cancer. (2007 Sep 1)Gorlov IPCancer Res