Gene: SSBP3

23648
CSDP|SSDP|SSDP1
single stranded DNA binding protein 3
protein-coding
1p32.3
Ensembl:ENSG00000157216 MIM:607390 Vega:OTTHUMG00000008264 UniprotKB:Q9BWW4
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.222e-1 (AD)  6.183e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4927081chr1:54290669 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYN10.959
SLC25A220.959
CLIP30.944
GPI0.943
EEF1A20.942
PRKAR1B0.942
DNM10.94
MAPK8IP20.939
KLHDC30.939
GSK3A0.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.691
OR4F29-0.657
TFPI2-0.384
KCNJ15-0.358
RAI14-0.356
CXCR2-0.35
CNN2-0.348
REST-0.346
CLEC2B-0.346
CD48-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SSBP3 mRNA19933214
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SSBP3 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SSBP3 mRNA"15215175
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SSBP3 mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of SSBP3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of SSBP3 mRNA27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of SSBP3 mRNA22521957
C015001arsenitearsenite results in increased methylation of SSBP3 promoter23974009
C547126AZM551248AZM551248 results in decreased expression of SSBP3 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SSBP3 mRNA20106945|2231617
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SSBP3 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SSBP3 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SSBP3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SSBP3 mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SSBP3 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of SSBP3 mRNA18353800
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SSBP3 mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of SSBP3 mRNA20106945
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SSBP3 mRNA28628672
D003976DiazinonDiazinon results in increased methylation of SSBP3 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of SSBP3 mRNA21266533
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SSBP3 mRNA22079256
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SSBP3 mRNA20938992
D005839GentamicinsGentamicins results in decreased expression of SSBP3 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SSBP3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of SSBP3 mRNA28628672
C008261lead acetate[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SSBP3 mRNA22839698
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SSBP3 mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SSBP3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SSBP3 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of SSBP3 mRNA19812364
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SSBP3 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of SSBP3 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of SSBP3 mRNA25729387
C006253pirinixic acidpirinixic acid results in decreased expression of SSBP3 mRNA18445702
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SSBP3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SSBP3 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SSBP3 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of SSBP3 mRNA21278054
D011748PyrogallolPyrogallol results in increased expression of SSBP3 mRNA20362636
D053260SootSoot results in decreased expression of SSBP3 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SSBP3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SSBP3 mRNA15358164|2121527
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of SSBP3 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of SSBP3 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of SSBP3 mRNA28973697
D014520UrethaneUrethane results in increased expression of SSBP3 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of SSBP3 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SSBP3 gene25560391
C029297vinylidene chloridevinylidene chloride results in decreased expression of SSBP3 mRNA26682919
C017803zinc protoporphyrin[lead acetate co-treated with zinc protoporphyrin] results in increased expression of SSBP3 mRNA22839698

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0003697single-stranded DNA binding-IEA-  
GO:0005515protein binding-IPI18330356  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0021501prechordal plate formation-IEA-  
GO:0021547midbrain-hindbrain boundary initiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0060322head development-IBA21873635  
GO:0060323head morphogenesis-IEA-  
GO:0065003protein-containing complex assembly-IEA-  
GO:2000744positive regulation of anterior head development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0032991protein-containing complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal