Gene: NEIL2

252969
NEH2|NEI2
nei like DNA glycosylase 2
protein-coding
8p23.1
Ensembl:ENSG00000154328 MIM:608933 Vega:OTTHUMG00000090753 UniprotKB:Q969S2
NG_053043.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.140e-1 (AD)  3.915e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs804292chr8:11786406 (GRCh38.p7)G>Aalcohol dependence|nicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PSMA70.896
SRSF90.895
NUDC0.895
ALKBH50.892
EIF3I0.887
CD2BP20.887
BCAP310.886
HAX10.886
UBB0.886
HSP90AB10.884

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.756
OR4F29-0.737
P2RY14-0.272
VNN3-0.259
KRT73-0.225
IL18RAP-0.224
KLRF1-0.223
FMO3-0.221
FCRL1-0.22
XCL2-0.218

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01592IronSmall Molecule7439-89-6ApprovedTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL2 mRNA"27188386
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in increased expression of NEIL2 mRNA]21233418
C023650anilineaniline results in increased expression of NEIL223352893
C023650anilineaniline results in increased expression of NEIL2 mRNA21145906
C023650anilineaniline results in increased expression of NEIL2 protein21145906
D001151ArsenicArsenic affects the methylation of NEIL2 gene25304211
C547126AZM551248AZM551248 results in decreased expression of NEIL2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to NEIL2 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NEIL2 mRNA22228805
D004958EstradiolEstradiol affects the expression of NEIL2 mRNA22574217
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in decreased expression of NEIL2 mRNA"20162321
C006780bisphenol Abisphenol A affects the expression of NEIL2 mRNA25181051
D003300CopperCopper binds to and results in decreased activity of NEIL2 protein20622253
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of NEIL2 mRNA20971185
D016572CyclosporineCyclosporine results in increased expression of NEIL2 mRNA25562108
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of NEIL2 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NEIL2 mRNA27392435
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in increased expression of NEIL2 mRNA]21233418
D004967EstrogensEstrogens results in increased expression of NEIL2 mRNA21233418
D015025ZearalenoneZearalenone results in increased expression of NEIL2 mRNA19371625
C039281furanfuran results in increased expression of NEIL2 mRNA25539665
D019833GenisteinGenistein results in increased expression of NEIL2 mRNA19371625
D007501IronIron binds to and results in decreased activity of NEIL2 protein20622253
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NEIL2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of NEIL2 mRNA27392435
C410337K 7174K 7174 results in decreased expression of NEIL2 mRNA24086573
D007854LeadLead affects the expression of NEIL2 mRNA28903495
C042720mercuric bromidemercuric bromide results in decreased expression of NEIL2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL2 mRNA"27188386
D008727MethotrexateMethotrexate results in decreased expression of NEIL2 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NEIL2 mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of NEIL2 mRNA20971185
C016340o,p'-DDT"o,p'-DDT results in increased expression of NEIL2 mRNA"19371625
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEIL2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of NEIL2 mRNA26272509
D011192Potassium DichromatePotassium Dichromate results in increased expression of NEIL2 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of NEIL2 mRNA23012394
C059514resveratrolresveratrol results in increased expression of NEIL2 mRNA19371625
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of NEIL2 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NEIL2 promoter]19654925
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of NEIL2 mRNA29024780
D014501UraniumUranium affects the expression of NEIL2 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of NEIL2 mRNA15672453

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-IEA-  
GO:0003906DNA-(apurinic or apyrimidinic site) endonuclease activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0008017microtubule binding-IEA-  
GO:0008270zinc ion binding-IEA-  
GO:0019104DNA N-glycosylase activity-IBA21873635  
GO:0019104DNA N-glycosylase activity-TAS-  
GO:0140078class I DNA-(apurinic or apyrimidinic site) endonuclease activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006284base-excision repair-IBA21873635  
GO:0006289nucleotide-excision repair-IEA-  
GO:0045008depyrimidination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0005876spindle microtubule-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110328Recognition and association of DNA glycosylase with site containing an affected pyrimidineTAS
R-HSA-110329Cleavage of the damaged pyrimidine TAS
R-HSA-5649702APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayTAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73928DepyrimidinationTAS
R-HSA-73929Base-Excision Repair, AP Site FormationTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23951112Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk. (2013)Corral RPLoS One
24595271NEIL2 protects against oxidative DNA damage induced by sidestream smoke in human cells. (2014)Sarker AHPLoS One