Gene: ZDHHC23

254887
DHHC-23|NIDD
zinc finger DHHC-type containing 23
protein-coding
3q13.31
Ensembl:ENSG00000184307 MIM:617334 Vega:OTTHUMG00000159335 UniprotKB:Q8IYP9
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.243e-1 (AD)  8.377e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3903132chr3:113981879 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UNC790.925
GRIN2B0.921
DGKI0.92
WSCD20.92
PLCL20.917
ST8SIA30.916
SCN3B0.916
AJAP10.914
HOMER10.913
LMTK20.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.61
HEY2-0.598
RAB13-0.595
MYL3-0.594
YES1-0.584
ROM1-0.562
RNF135-0.553
SNHG18-0.551
ASB4-0.551
FAM89A-0.541

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of ZDHHC23 mRNA"20453058
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ZDHHC23 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ZDHHC23 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZDHHC23 mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of ZDHHC23 mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZDHHC23 mRNA"27188386
D000638AmiodaroneAmiodarone affects the expression of ZDHHC23 mRNA19483382
D001553BenzbromaroneBenzbromarone affects the expression of ZDHHC23 mRNA19483382
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ZDHHC23 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZDHHC23 mRNA21839799
C006780bisphenol Abisphenol A results in increased expression of ZDHHC23 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ZDHHC23 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ZDHHC23 gene28505145
D004390ChlorpyrifosChlorpyrifos results in decreased expression of ZDHHC23 mRNA18668222
D002994ClofibrateClofibrate affects the expression of ZDHHC23 mRNA19483382
D003314Corn OilCorn Oil affects the expression of ZDHHC23 mRNA16360708
D003471CuprizoneCuprizone results in decreased expression of ZDHHC23 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ZDHHC23 mRNA25562108
D002945CisplatinCisplatin results in decreased expression of ZDHHC23 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of ZDHHC23 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in decreased expression of ZDHHC23 mRNA26033743
D005001EthionineEthionine affects the expression of ZDHHC23 mRNA19483382
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ZDHHC23 mRNA22634610
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ZDHHC23 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of ZDHHC23 mRNA26191083
D007649KetamineKetamine results in decreased expression of ZDHHC23 mRNA20080153
C045463leflunomideleflunomide results in decreased expression of ZDHHC23 mRNA28988120
D009853OmeprazoleOmeprazole affects the expression of ZDHHC23 mRNA19483382
C006253pirinixic acidpirinixic acid affects the expression of ZDHHC23 mRNA19483382
D011441PropylthiouracilPropylthiouracil affects the expression of ZDHHC23 mRNA19483382
D011794QuercetinQuercetin results in decreased expression of ZDHHC23 mRNA21632981
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of ZDHHC23 mRNA25905778
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of ZDHHC23 mRNA25905778
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ZDHHC23 mRNA21632981
D013853ThioacetamideThioacetamide affects the expression of ZDHHC23 mRNA19483382
D014212TretinoinTretinoin results in decreased expression of ZDHHC23 mRNA23830798
D014212TretinoinTretinoin results in increased expression of ZDHHC23 mRNA21934132
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ZDHHC23 mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased methylation of ZDHHC23 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ZDHHC23 mRNA19101580|2317975
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ZDHHC23 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0019706protein-cysteine S-palmitoyltransferase activity-IBA21873635  
GO:0019706protein-cysteine S-palmitoyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006612protein targeting to membrane-IBA21873635  
GO:0018230peptidyl-L-cysteine S-palmitoylation-IBA21873635  
GO:0018345protein palmitoylation-IMP22399288  
GO:0072659protein localization to plasma membrane-IMP22399288  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005794Golgi apparatus-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal