Gene: NEGR1

257194
DMML2433|IGLON4|KILON|Ntra
neuronal growth regulator 1
protein-coding
1p31.1
Ensembl:ENSG00000172260 MIM:613173 Vega:OTTHUMG00000009698 UniprotKB:Q7Z3B1
NC_000001.11
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.467e-1 (AD)  7.509e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1157072chr1:72169229 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAXC0.976
NELL20.975
SYT40.974
FGF120.973
SNAP910.972
GABRG20.971
GLRB0.971
CNTNAP20.97
DYNC1I10.97
MAP7D20.969

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.563
HEY2-0.549
RNF135-0.543
CHST14-0.542
SYDE1-0.54
REST-0.54
RAB13-0.531
CNN2-0.529
RAI14-0.528
CMTM3-0.522

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NEGR1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEGR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEGR1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEGR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEGR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEGR1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEGR1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NEGR1 gene27153756
D001104ArbutinArbutin results in decreased expression of NEGR1 mRNA17103032
D001151ArsenicArsenic results in increased methylation of NEGR1 gene24525453
C487081belinostatbelinostat results in increased expression of NEGR1 mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of NEGR1 mRNA20713471
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of NEGR1 mRNA21453500
D004958EstradiolEstradiol results in decreased expression of NEGR1 mRNA19484750
D004958EstradiolEstradiol results in decreased expression of NEGR1 mRNA20068009
C006780bisphenol Abisphenol A affects the expression of NEGR1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NEGR1 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of NEGR1 mRNA25181051
C026690cerous chloridecerous chloride results in increased expression of NEGR1 mRNA23573234
D004390ChlorpyrifosChlorpyrifos affects the expression of NEGR1 mRNA26775027
D004390ChlorpyrifosChlorpyrifos results in decreased expression of NEGR1 mRNA18668222
C018021cobaltous chloridecobaltous chloride results in decreased expression of NEGR1 mRNA19320972
D016572CyclosporineCyclosporine results in decreased methylation of NEGR1 promoter27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of NEGR1 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of NEGR1 mRNA18042831
D002117CalcitriolCalcitriol results in decreased expression of NEGR1 mRNA26485663
C118739entinostatentinostat results in increased expression of NEGR1 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEGR1 mRNA"27188386
D005419FlavonoidsFlavonoids results in decreased expression of NEGR1 mRNA18035473
D017313FenretinideFenretinide results in decreased expression of NEGR1 mRNA28973697
C045463leflunomideleflunomide results in decreased expression of NEGR1 mRNA24136188
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of NEGR1 mRNA26011545
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of NEGR1 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NEGR1 mRNA"25554681
D009532NickelNickel results in decreased expression of NEGR1 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in decreased expression of NEGR1 mRNA22714537
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of NEGR1 mRNA27935865
D000073878Palm OilPalm Oil results in decreased expression of NEGR1 mRNA18042831
C496932panobinostatpanobinostat results in increased expression of NEGR1 mRNA27188386
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NEGR1 mRNA"27188386
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of NEGR1 mRNA27935865
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of NEGR1 mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of NEGR1 mRNA21453500
D011441PropylthiouracilPropylthiouracil results in increased expression of NEGR1 mRNA24780913
D012906SmokeSmoke results in increased expression of NEGR1 mRNA21095227
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NEGR1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NEGR1 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NEGR1 mRNA21354282
D013849ThimerosalThimerosal results in decreased expression of NEGR1 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of NEGR1 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of NEGR1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of NEGR1 mRNA24935251|2670570
D014303TrinitrotolueneTrinitrotoluene affects the expression of NEGR1 mRNA21346803
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NEGR1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NEGR1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NEGR1 mRNA19101580|2317975
D014638VanadatesVanadates results in increased expression of NEGR1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions affects the methylation of NEGR1 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of NEGR1 mRNA25423262
C025643vinclozolinvinclozolin affects the expression of NEGR1 mRNA19015723
C111237vorinostatvorinostat results in increased expression of NEGR1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21982860  27940359  
GO ID GO Term Qualifier Evidence PubMed
GO:0007626locomotory behavior-IEA-  
GO:0007631feeding behavior-IEA-  
GO:0010976positive regulation of neuron projection development-IEA-  
GO:0098609cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0031225anchored component of membrane-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
Reactome ID Reactome Term Evidence
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal