Gene: KIAA1549L

25758
C11orf41|C11orf69|G2
KIAA1549 like
protein-coding
11p13
Ensembl:ENSG00000110427 MIM:612297 Vega:OTTHUMG00000150410 UniprotKB:Q6ZVL6
NC_000011.10
SNP Mapped
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.608e-1 (AD)  4.740e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs386752273chr11:33393606-33393607 (GRCh38.p7)GG>TAalcohol dependenceMNVMultipleNucleotideVariation
rs12291056chr11:33393605 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
THRB0.981
DLGAP10.977
AAK10.975
KCNB10.975
SV2B0.975
HCN10.973
MYT1L0.972
ATRNL10.971
CHRM30.971
FRMPD40.97

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL3-0.6
HEY2-0.596
RAB13-0.579
YES1-0.577
SNHG18-0.576
RNF135-0.574
WWTR1-0.573
REST-0.573
CSAG1-0.571
TFPI2-0.569

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1549L mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1549L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1549L mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1549L mRNA"27188386
D001280AtrazineAtrazine results in decreased expression of KIAA1549L mRNA22378314
C487081belinostatbelinostat results in decreased expression of KIAA1549L mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1549L mRNA"27188386
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KIAA1549L mRNA"20382639
D004958EstradiolEstradiol affects the expression of KIAA1549L mRNA14699072
C006780bisphenol Abisphenol A results in decreased expression of KIAA1549L mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KIAA1549L mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KIAA1549L mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of KIAA1549L mRNA27392435
D002945CisplatinCisplatin results in decreased expression of KIAA1549L mRNA27392435
D004317DoxorubicinKIAA1549L protein affects the susceptibility to Doxorubicin16217747
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KIAA1549L mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of KIAA1549L mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of KIAA1549L mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of KIAA1549L mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of KIAA1549L mRNA25119042
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of KIAA1549L mRNA"24972896
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of KIAA1549L mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of KIAA1549L mRNA25119042
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KIAA1549L mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of KIAA1549L mRNA26272509
D010936Plant ExtractsPlant Extracts results in decreased expression of KIAA1549L mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of KIAA1549L mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of KIAA1549L mRNA25895662
C012589trichostatin Atrichostatin A results in increased expression of KIAA1549L mRNA24935251
D014635Valproic AcidValproic Acid results in decreased expression of KIAA1549L mRNA23179753|2718838
C111237vorinostatvorinostat results in decreased expression of KIAA1549L mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal