Gene: ATXN10

25814
E46L|HUMEEP|SCA10
ataxin 10
protein-coding
22q13.31
Ensembl:ENSG00000130638 MIM:611150 Vega:OTTHUMG00000150451 UniprotKB:Q9UBB4
NG_016212.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.712e-1 (AD)  5.133e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7284693chr22:45817711 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20269537chr22:46067074ATXN10Promoter1.170e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UQCRC20.977
ATP6AP20.974
COPS40.972
ACTR100.972
DCTN20.968
NDFIP10.968
OCIAD10.962
OAT0.962
DDX10.962
RAB2A0.962

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.685
OR4F29-0.629
MTRNR2L6-0.391
CSAG1-0.388
MTRNR2L9-0.374
MTRNR2L10-0.362
RAI14-0.361
KCNJ15-0.35
S100A12-0.347
MAGEA12-0.346

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ATXN10 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ATXN10 mRNA]"19467301
D000082AcetaminophenAcetaminophen affects the expression of ATXN10 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ATXN10 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ATXN10 mRNA]17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ATXN10 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ATXN10 mRNA24449571
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ATXN10 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATXN10 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ATXN10 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ATXN10 gene28505145
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ATXN10 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ATXN10 mRNA]17585979
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATXN10 mRNA17602206
D019327Copper SulfateCopper Sulfate results in decreased expression of ATXN10 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ATXN10 mRNA25562108
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ATXN10 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ATXN10 mRNA21266533
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ATXN10 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of ATXN10 mRNA19467301
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ATXN10 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ATXN10 mRNA17602206
D004237DiuronDiuron results in increased expression of ATXN10 mRNA21551480
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ATXN10 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ATXN10 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATXN10 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ATXN10 mRNA23649840
D018120FinasterideFinasteride results in increased expression of ATXN10 mRNA24136188
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of ATXN10 mRNA]15016801
C056933fumonisin B1fumonisin B1 results in increased expression of ATXN10 mRNA16221962
D005839GentamicinsGentamicins results in increased expression of ATXN10 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of ATXN10 mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of ATXN10 mRNA20003209
C410337K 7174K 7174 results in decreased expression of ATXN10 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ATXN10 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ATXN10 mRNA23649840
D010416PentachlorophenolPentachlorophenol results in increased expression of ATXN10 mRNA23892564
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ATXN10 protein26178269
C006253pirinixic acidpirinixic acid results in increased expression of ATXN10 mRNA16221962|1830175
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of ATXN10 mRNA]20059764
C017947sodium arsenitesodium arsenite results in decreased expression of ATXN10 mRNA19072884
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATXN10 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with AHR gene mutant form] results in increased expression of ATXN10 mRNA19465110
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATXN10 mRNA17942748
D014501UraniumUranium affects the expression of ATXN10 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of ATXN10 mRNA15672453
D014520UrethaneUrethane results in decreased expression of ATXN10 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of ATXN10 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ATXN10 mRNA23179753

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16498633  21565611  
GO:0019899enzyme binding-IEA-  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-IMP16385455  
GO:0031175neuron projection development-IDA16498633  
GO:0060271cilium assembly-IEA-  
GO:0070207protein homotrimerization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA23580065  
GO:0005737cytoplasm-IDA15201271  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA-  
GO:0016020membrane-HDA19946888  
GO:0030425dendrite-IDA15201271  
GO:0043025neuronal cell body-IDA15201271  
GO:0048471perinuclear region of cytoplasm-IDA15201271  16498633  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal