Gene: ABTB2

25841
ABTB2A|BTBD22
ankyrin repeat and BTB domain containing 2
protein-coding
11p13
Ensembl:ENSG00000166016 Vega:OTTHUMG00000044382 UniprotKB:Q8N961
NC_000011.10
SNP Mapped
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.093e-1 (AD)  1.366e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7105914chr11:34245136 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs2473918chr11:34169406 (GRCh38.p7)T>Cnicotine dependenceSNV(Single Nucleotide Variation)
rs745809chr11:34166300 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03502889chr11:34255733ABTB22.500e-9Smoking27651444
cg23845009chr11:34323678ABTB21.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ELOVL50.764
SH3PXD2B0.763
RRBP10.755
CSF10.746
MAPKAPK20.743
FZD50.739
NPC10.738
SLC39A10.738
PREX10.735
KCTD50.733

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.332
SULT2B1-0.328
OR4F29-0.317
SMIM18-0.314
CACNA1F-0.312
LHX6-0.309
SAMD5-0.305
ABCC12-0.3
CD6-0.298
SLC7A4-0.291

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABTB2 mRNA"22698814
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ABTB2 mRNA28329830
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ABTB2 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ABTB2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABTB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABTB2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ABTB2 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of ABTB2 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ABTB2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ABTB2 mRNA24449571
D001151ArsenicArsenic affects the methylation of ABTB2 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABTB2 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ABTB2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABTB2 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of ABTB2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ABTB2 gene28505145
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ABTB2 mRNA17484886
D019327Copper SulfateCopper Sulfate results in increased expression of ABTB2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of ABTB2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of ABTB2 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in increased expression of ABTB2 mRNA24921660
D003703DemecolcineDemecolcine results in increased expression of ABTB2 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ABTB2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ABTB2 mRNA19561079
C000944dicrotophosdicrotophos results in increased expression of ABTB2 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of ABTB2 mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of ABTB2 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ABTB2 mRNA21318169
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ABTB2 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ABTB2 mRNA]17942915
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of ABTB2 mRNA28939011
D004317DoxorubicinDoxorubicin affects the expression of ABTB2 mRNA25529476
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of ABTB2 mRNA28329830
D005485FlutamideFlutamide results in decreased expression of ABTB2 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of ABTB2 mRNA23649840
D005897GlafenineGlafenine results in decreased expression of ABTB2 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ABTB2 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ABTB2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ABTB2 mRNA24796395|2743299
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ABTB2 mRNA21641980
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ABTB2 mRNA28001369
C523799MRK 003ABTB2 results in increased susceptibility to MRK 00319903844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ABTB2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ABTB2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ABTB2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ABTB2 mRNA"25554681|2562005
D010100OxygenOxygen deficiency results in increased expression of ABTB2 mRNA24205000
D000073878Palm OilPalm Oil results in increased expression of ABTB2 mRNA18042831
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ABTB2 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ABTB2 mRNA23948077
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ABTB2 mRNA19162173|2131816
D010634PhenobarbitalPhenobarbital affects the expression of ABTB2 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of ABTB2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ABTB2 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABTB2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ABTB2 mRNA26272509
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ABTB2 mRNA28903501
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ABTB2 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of ABTB2 mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of ABTB2 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in increased expression of ABTB2 mRNA25351596
C017947sodium arsenitesodium arsenite results in increased expression of ABTB2 mRNA21281968
D053260SootSoot results in increased expression of ABTB2 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ABTB2 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ABTB2 mRNA21570461|2892240
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABTB2 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ABTB2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ABTB2 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ABTB2 mRNA28065790
C022884undecaneundecane results in decreased expression of ABTB2 protein17337753
D014520UrethaneUrethane results in increased expression of ABTB2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of ABTB2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of ABTB2 mRNA24383497|2627250
D014635Valproic AcidValproic Acid affects the expression of ABTB2 mRNA17292431|1796380
D014750VincristineVincristine results in increased expression of ABTB2 mRNA23649840
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ABTB2 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0097237cellular response to toxic substance-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal