Gene info: ID 25841

SNP ID	Position	Alleles	Trait	Variation Type
rs7105914	chr11:34245136 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs2473918	chr11:34169406 (GRCh38.p7)	T>C	nicotine dependence	SNV(Single Nucleotide Variation)
rs745809	chr11:34166300 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg03502889	chr11:34255733	ABTB2		2.500e-9	Smoking	27651444
cg23845009	chr11:34323678	ABTB2		1.100e-8	Smoking	27651444

Gene Symbol	Pearson Correlation Coefficient
ELOVL5	0.764
SH3PXD2B	0.763
RRBP1	0.755
CSF1	0.746
MAPKAPK2	0.743
FZD5	0.739
NPC1	0.738
SLC39A1	0.738
PREX1	0.735
KCTD5	0.733

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.332
SULT2B1	-0.328
OR4F29	-0.317
SMIM18	-0.314
CACNA1F	-0.312
LHX6	-0.309
SAMD5	-0.305
ABCC12	-0.3
CD6	-0.298
SLC7A4	-0.291

DrugBank
CTD

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ABTB2 mRNA"	22698814
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of ABTB2 mRNA	28329830
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ABTB2 mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ABTB2 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABTB2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABTB2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of ABTB2 mRNA	21420995\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of ABTB2 mRNA	17562736
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ABTB2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ABTB2 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of ABTB2 gene	25304211
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ABTB2 mRNA	26238291
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ABTB2 mRNA	19770486
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ABTB2 mRNA"	19150397
C006780	bisphenol A	bisphenol A results in increased expression of ABTB2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of ABTB2 gene	28505145
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ABTB2 mRNA	17484886
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ABTB2 mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of ABTB2 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in increased expression of ABTB2 mRNA	20106945
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of ABTB2 mRNA	24921660
D003703	Demecolcine	Demecolcine results in increased expression of ABTB2 mRNA	23649840
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ABTB2 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of ABTB2 mRNA	19561079
C000944	dicrotophos	dicrotophos results in increased expression of ABTB2 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of ABTB2 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of ABTB2 mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ABTB2 mRNA	21318169
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of ABTB2 mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ABTB2 mRNA]	17942915
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of ABTB2 mRNA	28939011
D004317	Doxorubicin	Doxorubicin affects the expression of ABTB2 mRNA	25529476
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of ABTB2 mRNA	28329830
D005485	Flutamide	Flutamide results in decreased expression of ABTB2 mRNA	24136188
D005557	Formaldehyde	Formaldehyde results in increased expression of ABTB2 mRNA	23649840
D005897	Glafenine	Glafenine results in decreased expression of ABTB2 mRNA	24136188
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ABTB2 mRNA	20044591
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ABTB2 mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of ABTB2 mRNA	24796395\|2743299
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ABTB2 mRNA	21641980
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ABTB2 mRNA	28001369
C523799	MRK 003	ABTB2 results in increased susceptibility to MRK 003	19903844
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ABTB2 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ABTB2 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ABTB2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ABTB2 mRNA"	25554681\|2562005
D010100	Oxygen	Oxygen deficiency results in increased expression of ABTB2 mRNA	24205000
D000073878	Palm Oil	Palm Oil results in increased expression of ABTB2 mRNA	18042831
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of ABTB2 mRNA	18593933
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of ABTB2 mRNA	23948077
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ABTB2 mRNA	19162173\|2131816
D010634	Phenobarbital	Phenobarbital affects the expression of ABTB2 mRNA	19159669
D010634	Phenobarbital	Phenobarbital affects the expression of ABTB2 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in increased expression of ABTB2 mRNA	19270015
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ABTB2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of ABTB2 mRNA	26272509
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ABTB2 mRNA	28903501
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of ABTB2 mRNA	19162173
D011374	Progesterone	Progesterone results in decreased expression of ABTB2 mRNA	23012394
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ABTB2 mRNA	24780913
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of ABTB2 mRNA	25351596
C017947	sodium arsenite	sodium arsenite results in increased expression of ABTB2 mRNA	21281968
D053260	Soot	Soot results in increased expression of ABTB2 mRNA	26551751
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of ABTB2 mRNA	21641980
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ABTB2 mRNA	21570461\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ABTB2 mRNA	26290441
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ABTB2 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ABTB2 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ABTB2 mRNA	28065790
C022884	undecane	undecane results in decreased expression of ABTB2 protein	17337753
D014520	Urethane	Urethane results in increased expression of ABTB2 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in decreased methylation of ABTB2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ABTB2 mRNA	24383497\|2627250
D014635	Valproic Acid	Valproic Acid affects the expression of ABTB2 mRNA	17292431\|1796380
D014750	Vincristine	Vincristine results in increased expression of ABTB2 mRNA	23649840
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of ABTB2 mRNA	18593933

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003674	molecular_function	-	ND	-
GO:0046982	protein heterodimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005575	cellular_component	-	ND	-
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	IDA	-

Gene: ABTB2

ANCO-SNPs

DNA Methylation

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

There is no DrugBank record for this gene !

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)