Gene: GALNT2

2590
GalNAc-T2
polypeptide N-acetylgalactosaminyltransferase 2
protein-coding
1q42.13
Ensembl:ENSG00000143641 MIM:602274 Vega:OTTHUMG00000037771 UniprotKB:Q10471
NG_011854.2
PubMed|SNP Mapped
10   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.200e-2 (AD)  8.024e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7541570chr1:230129595 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs10864699chr1:230128860 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12086347chr1:230127626 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12724775chr1:230111376 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs12732392chr1:230109219 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs12751815chr1:230106833 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12035297chr1:230103074 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs12726525chr1:230099285 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs910821chr1:230096494 (GRCh38.p7)T>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs10779824chr1:230095509 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03144619chr1:230415668GALNT21.170e-16Maternal smoking in pregnancy27040690
cg24591105chr1:230415225GALNT23.770e-12Maternal smoking in pregnancy27040690
cg05697274chr1:230415377GALNT22.210e-14Maternal smoking in pregnancy27040690
cg24250902chr1:230415547GALNT21.080e-12Maternal smoking in pregnancy27040690
cg19727396chr1:230415185GALNT21.750e-11Maternal smoking in pregnancy27040690
cg16517298chr1:230413174GALNT21.180e-10Maternal smoking in pregnancy27040690
cg00589617chr1:230415343GALNT25.360e-12Maternal smoking in pregnancy27040690
cg03144619chr1:230415668GALNT21.530e-19Maternal smoking in pregnancy27040690
cg24591105chr1:230415225GALNT23.550e-16Maternal smoking in pregnancy27040690
cg05697274chr1:230415377GALNT25.240e-16Maternal smoking in pregnancy27040690
cg24250902chr1:230415547GALNT26.630e-16Maternal smoking in pregnancy27040690
cg19727396chr1:230415185GALNT24.450e-15Maternal smoking in pregnancy27040690
cg16517298chr1:230413174GALNT23.240e-13Maternal smoking in pregnancy27040690
cg00589617chr1:230415343GALNT26.920e-13Maternal smoking in pregnancy27040690
cg11527913chr1:230410329GALNT26.400e-9Maternal smoking in pregnancy27040690
cg00526336chr1:230415902GALNT21.450e-8Maternal smoking in pregnancy27040690
cg03144619chr1:230415668GALNT27.520e-18Maternal smoking in pregnancy27040690
cg24591105chr1:230415225GALNT23.680e-15Maternal smoking in pregnancy27040690
cg05697274chr1:230415377GALNT25.070e-16Maternal smoking in pregnancy27040690
cg24250902chr1:230415547GALNT23.980e-15Maternal smoking in pregnancy27040690
cg19727396chr1:230415185GALNT25.560e-17Maternal smoking in pregnancy27040690
cg16517298chr1:230413174GALNT22.940e-18Maternal smoking in pregnancy27040690
cg00589617chr1:230415343GALNT24.680e-12Maternal smoking in pregnancy27040690
cg11527913chr1:230410329GALNT27.040e-10Maternal smoking in pregnancy27040690
cg00526336chr1:230415902GALNT23.980e-10Maternal smoking in pregnancy27040690
cg00526336chr1:230415902GALNT22.900e-11Smoking27651444
cg11527913chr1:230410329GALNT21.600e-9Smoking27651444
cg03144619chr1:230415668GALNT24.300e-8Smoking27651444
cg00526336chr1:230415902GALNT21.090e-9Smoking28686328
cg03144619chr1:230415668GALNT22.500e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF40.892
P4HB0.881
ISG20L20.864
SURF40.863
TXNRD10.857
BAHD10.85
CSNK1A10.847
DDOST0.847
SEC23B0.845
TFIP110.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.603
OR4F29-0.537
CTNNA3-0.323
TNFRSF13B-0.286
OR6C74-0.282
KLRK1-0.269
C5orf64-0.258
KLRC2-0.246
KLRC3-0.244
C17orf112-0.238

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolGALNT2 protein results in decreased susceptibility to 1-UFT protocol16734730
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GALNT2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GALNT2 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GALNT2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of GALNT2 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of GALNT2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GALNT2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GALNT2 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of GALNT2 mRNA24449571
D001507BeclomethasoneBeclomethasone results in decreased expression of GALNT2 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GALNT2 mRNA20064835
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of GALNT2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GALNT2 mRNA19770486|2222880
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GALNT2 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of GALNT2 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of GALNT2 promoter27415467
C006780bisphenol Abisphenol A results in increased expression of GALNT2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GALNT2 gene28505145
C459604candoxincandoxin results in decreased expression of GALNT2 mRNA16309724
D002220CarbamazepineCarbamazepine affects the expression of GALNT2 mRNA25979313
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of GALNT2 mRNA16197558
C039671ciglitazone[ciglitazone binds to PPARG protein] which results in increased expression of GALNT2 mRNA16197558
D002922CiguatoxinsCiguatoxins affects the expression of GALNT2 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of GALNT2 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of GALNT2 mRNA23811191
D003035Cobalt[Tungsten co-treated with Nickel co-treated with Cobalt] results in decreased expression of GALNT2 mRNA24619124
C018021cobaltous chloridecobaltous chloride results in decreased expression of GALNT2 mRNA24386269
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GALNT2 mRNA23914054
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GALNT2 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GALNT2 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GALNT2 mRNA21266533
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of GALNT2 mRNA17490981
D004052Diethylnitrosamine[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of GALNT2 gene23968726
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GALNT2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GALNT2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GALNT2 mRNA17942748
D005485FlutamideFlutamide analog results in decreased expression of GALNT2 mRNA17702527
D005485FlutamideFlutamide results in decreased expression of GALNT2 mRNA17702527
D005485FlutamideFlutamide results in decreased expression of GALNT2 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of GALNT2 mRNA23649840
C039281furanfuran results in increased methylation of GALNT2 gene22079235
D005839GentamicinsGentamicins results in decreased expression of GALNT2 mRNA22061828
D017313FenretinideFenretinide results in decreased expression of GALNT2 mRNA28973697
C492448ICG 001ICG 001 results in decreased expression of GALNT2 mRNA26191083
C045463leflunomideleflunomide results in increased expression of GALNT2 mRNA24136188
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GALNT2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GALNT2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GALNT2 mRNA"25620056
D009532NickelNickel results in increased expression of GALNT2 mRNA24768652|2558310
D009532Nickel[Tungsten co-treated with Nickel co-treated with Cobalt] results in decreased expression of GALNT2 mRNA24619124
C022838nickel chloridenickel chloride results in decreased expression of GALNT2 mRNA24619124
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GALNT2 mRNA23978341
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT2 mRNA"27188386
D010882Piperonyl Butoxide[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of GALNT2 gene23968726
C006253pirinixic acidpirinixic acid results in increased expression of GALNT2 mRNA18301758|1844570
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GALNT2 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GALNT2 mRNA28903501
D012402RotenoneRotenone results in decreased expression of GALNT2 mRNA17702527
D012969Sodium FluorideSodium Fluoride results in decreased expression of GALNT2 protein28918527
D013629TamoxifenTamoxifen affects the expression of GALNT2 mRNA17555576
C535112tantalum pentachloridetantalum pentachloride results in decreased expression of GALNT2 mRNA24619124
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GALNT2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GALNT2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GALNT2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GALNT2 mRNA17942748|1977048
D014414Tungsten[Tungsten co-treated with Nickel co-treated with Cobalt] results in decreased expression of GALNT2 mRNA24619124
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GALNT2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GALNT2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of GALNT2 mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GALNT2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004653polypeptide N-acetylgalactosaminyltransferase activity-IDA9295285  12438318  16434399  18562306  19460755  
GO:0004653polypeptide N-acetylgalactosaminyltransferase activity-TAS-  
GO:0005515protein binding-IPI21699783  25416956  
GO:0030145manganese ion binding-IDA9295285  16434399  
GO:0030246carbohydrate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002378immunoglobulin biosynthetic process-IDA12438318  
GO:0006493protein O-linked glycosylation-IDA16434399  19460755  
GO:0016266O-glycan processing-IDA18562306  
GO:0016266O-glycan processing-TAS-  
GO:0018242protein O-linked glycosylation via serine-IDA9295285  12438318  
GO:0018243protein O-linked glycosylation via threonine-IDA9295285  12438318  18562306  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005794Golgi apparatus-IBA21873635  
GO:0005794Golgi apparatus-IDA9852147  
GO:0005794Golgi apparatuscolocalizes_withIDA12506059  
GO:0005795Golgi stack-IDA9852147  
GO:0016020membrane-HDA19946888  
GO:0030173integral component of Golgi membrane-NAS9852147  
GO:0032580Golgi cisterna membrane-IEA-  
GO:0048471perinuclear region of cytoplasm-IDA12506059  
KEGG ID KEGG Term
hsa00512Mucin type O-Glycan biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6811436COPI-independent Golgi-to-ER retrograde trafficTAS
R-HSA-6811442Intra-Golgi and retrograde Golgi-to-ER trafficTAS
R-HSA-8856688Golgi-to-ER retrograde transportTAS
R-HSA-913709O-linked glycosylation of mucinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23303382Genome-wide association study of serum albumin:globulin ratio in Korean populations. (2013 Mar)Hong KWJ Hum Genet
25084356A preliminary study of the relationship between promoter methylation of the ABCG1, GALNT2 and HMGCR genes and coronary heart disease. (2014)Peng PPLoS One
24906187Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. (2014 Oct)Markunas CAEnviron Health Perspect