Gene: HSPA12A

259217
-
heat shock protein family A (Hsp70) member 12A
protein-coding
10q25.3
Ensembl:ENSG00000165868 MIM:610701 Vega:OTTHUMG00000019107 UniprotKB:O43301
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.951e-1 (AD)  1.752e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7097645chr10:116800966 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP2K40.975
NDRG30.972
PIK3CB0.972
GLS0.971
NSF0.971
REPS20.969
MAPK90.968
WDR70.968
DOCK30.968
PPP3CB0.968

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.528
MYL3-0.509
RAB13-0.501
HEY2-0.499
CSAG1-0.498
REST-0.492
OR4F5-0.49
YES1-0.485
CHST14-0.483
WWTR1-0.482

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HSPA12A mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of HSPA12A mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of HSPA12A mRNA29067470
D001151ArsenicArsenic affects the methylation of HSPA12A gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HSPA12A mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HSPA12A mRNA"20382639
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HSPA12A mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of HSPA12A mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HSPA12A mRNA28628672
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HSPA12A25705660
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of HSPA12A mRNA26272509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HSPA12A gene20938992
D016572CyclosporineCyclosporine results in decreased expression of HSPA12A mRNA25562108
C014347decitabinedecitabine affects the expression of HSPA12A mRNA23300844
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HSPA12A mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HSPA12A mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HSPA12A mRNA21266533
D002945CisplatinCisplatin affects the expression of HSPA12A mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HSPA12A mRNA27392435
D002945CisplatinCisplatin results in increased expression of HSPA12A mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of HSPA12A mRNA25016146
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of HSPA12A mRNA21040762
C118739entinostatentinostat results in increased expression of HSPA12A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HSPA12A gene20938992
D005947GlucoseGlucose results in decreased expression of HSPA12A protein22413817
D005947GlucoseKU-32 compound inhibits the reaction [Glucose results in decreased expression of HSPA12A protein]22413817
D017313FenretinideFenretinide results in decreased expression of HSPA12A mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HSPA12A mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HSPA12A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HSPA12A mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HSPA12A mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HSPA12A mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HSPA12A mRNA25307878
C581040KU-32 compoundKU-32 compound inhibits the reaction [Glucose results in decreased expression of HSPA12A protein]22413817
C045463leflunomideleflunomide results in increased expression of HSPA12A mRNA28988120
D018021Lithium ChlorideLithium Chloride results in decreased expression of HSPA12A mRNA23527032
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of HSPA12A mRNA16507785
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HSPA12A gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HSPA12A mRNA"26251327
C523799MRK 003MRK 003 results in decreased expression of HSPA12A mRNA21169257
C523799MRK 003HSPA12A results in increased susceptibility to MRK 00319903844
C029938nickel sulfatenickel sulfate results in increased expression of HSPA12A mRNA22714537
C006253pirinixic acidpirinixic acid results in decreased expression of HSPA12A mRNA20813756
D010936Plant ExtractsPlant Extracts results in decreased expression of HSPA12A mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HSPA12A mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in decreased expression of HSPA12A mRNA23608068
D011441PropylthiouracilPropylthiouracil results in decreased expression of HSPA12A mRNA24780913
D011794QuercetinQuercetin results in increased expression of HSPA12A mRNA21632981
D012822Silicon DioxideSilicon Dioxide results in increased expression of HSPA12A mRNA25351596
D012835Silver NitrateSilver Nitrate analog results in decreased expression of HSPA12A mRNA22831968
C017947sodium arsenitesodium arsenite affects the methylation of HSPA12A gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HSPA12A mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HSPA12A mRNA26232522
D014212TretinoinTretinoin results in decreased expression of HSPA12A mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of HSPA12A gene27618143
C012589trichostatin Atrichostatin A results in increased expression of HSPA12A mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSPA12A mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HSPA12A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HSPA12A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HSPA12A mRNA23179753|2438349
C088658zoledronic acidzoledronic acid results in decreased expression of HSPA12A mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2262752Cellular responses to stressTAS
R-HSA-3371453Regulation of HSF1-mediated heat shock responseTAS
R-HSA-3371556Cellular response to heat stressTAS
R-HSA-8953897Cellular responses to external stimuliTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal