Gene: MOXD1

26002
MOX|PRO5780|dJ248E1.1
monooxygenase DBH like 1
protein-coding
6q23.2
Ensembl:ENSG00000079931 MIM:609000 Vega:OTTHUMG00000055853 UniprotKB:Q6UVY6
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.000e-2 (AD)  4.543e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6903616chr6:132296330 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM171B0.709
CHRDL10.705
GABRA20.677
NTRK20.655
FAM184A0.649
ACSL60.648
ZHX30.643
BBS20.641
DDAH10.635
SLC1A20.634

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF35-0.42
SLAMF6-0.408
FAM20A-0.398
SPINK8-0.398
CD48-0.398
TNFAIP8-0.391
FOXI2-0.383
TFPI2-0.381
GRAP2-0.379
LINC00189-0.379

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MOXD1 mRNA"25614096
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of MOXD1 mRNA25088246
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MOXD1 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MOXD1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MOXD1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MOXD1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MOXD1 gene27153756
D000447AldehydesAldehydes results in increased expression of MOXD1 mRNA25014914
C015001arsenitearsenite results in increased methylation of MOXD1 promoter23974009
C547126AZM551248AZM551248 results in increased expression of MOXD1 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of MOXD1 mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of MOXD1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MOXD1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MOXD1 mRNA22300585
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of MOXD1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of MOXD1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of MOXD1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of MOXD1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of MOXD1 mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MOXD1 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of MOXD1 mRNA26079696
D002104CadmiumCadmium results in increased expression of MOXD1 mRNA23256528
D019256Cadmium Chloride[nickel chloride co-treated with Cadmium Chloride] results in increased expression of MOXD1 mRNA19187980
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MOXD1 mRNA19031917|2136216
D002220CarbamazepineCarbamazepine affects the expression of MOXD1 mRNA25979313
D004390ChlorpyrifosChlorpyrifos results in increased expression of MOXD1 mRNA21356183
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MOXD1 mRNA28472532
D003471CuprizoneCuprizone results in increased expression of MOXD1 mRNA27523638
D003976DiazinonDiazinon results in increased methylation of MOXD1 gene22964155
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of MOXD1 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MOXD1 mRNA27392435
D004041Dietary FatsDietary Fats affects the expression of MOXD1 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of MOXD1 mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MOXD1 mRNA28085963
D004397FonofosFonofos results in increased methylation of MOXD1 promoter22847954
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MOXD1 mRNA27392435
D007840LatexLatex analog results in increased expression of MOXD1 mRNA24768652
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MOXD1 mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MOXD1 mRNA25613284
D009532NickelNickel results in increased expression of MOXD1 mRNA25583101
C022838nickel chloridenickel chloride results in increased expression of MOXD1 mRNA24612858
C022838nickel chloride[nickel chloride co-treated with Cadmium Chloride] results in increased expression of MOXD1 mRNA19187980
C029938nickel sulfatenickel sulfate results in increased expression of MOXD1 mRNA22714537
D000073878Palm OilPalm Oil affects the expression of MOXD1 mRNA19680557
D000073878Palm OilPalm Oil results in increased expression of MOXD1 mRNA18042831
D010278ParathionParathion results in increased methylation of MOXD1 promoter22847954
C046012pentanalpentanal results in increased expression of MOXD1 mRNA26079696
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of MOXD1 mRNA22790973
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MOXD1 mRNA23427857
C031181phenanthrenephenanthrene results in decreased expression of MOXD1 mRNA19457238
C031181phenanthrenephenanthrene results in increased expression of MOXD1 mRNA19457238|2136216
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MOXD1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of MOXD1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of MOXD1 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MOXD1 mRNA19710929
C005556propionaldehydepropionaldehyde results in increased expression of MOXD1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of MOXD1 mRNA24780913
C502851quinocetonequinocetone results in increased expression of MOXD1 mRNA27046791
C016104sodium bichromatesodium bichromate results in increased expression of MOXD1 mRNA24612858
D012999SomanSoman results in increased expression of MOXD1 mRNA19281266
C013698tallowtallow affects the expression of MOXD1 mRNA19680557
C012568terbufosterbufos results in increased methylation of MOXD1 promoter22847954
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of MOXD1 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MOXD1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MOXD1 mRNA28922406
D013792ThalidomideThalidomide results in decreased expression of MOXD1 mRNA26217789
D014212TretinoinTretinoin results in increased expression of MOXD1 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of MOXD1 mRNA27188386
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MOXD1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MOXD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MOXD1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of MOXD1 mRNA24896083
D014638VanadatesVanadates results in increased expression of MOXD1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MOXD1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of MOXD1 mRNA23869203
D014810Vitamin EVitamin E results in increased expression of MOXD1 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of MOXD1 mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of MOXD1 mRNA"24525044
D015032ZincZinc deficiency results in decreased expression of MOXD1 mRNA19111725
C088658zoledronic acidzoledronic acid results in increased expression of MOXD1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004500dopamine beta-monooxygenase activity-IBA21873635  
GO:0005507copper ion binding-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0016715oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006589octopamine biosynthetic process-IBA21873635  
GO:0042420dopamine catabolic process-IBA21873635  
GO:0042421norepinephrine biosynthetic process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005789endoplasmic reticulum membrane-IDA15337741  
GO:0016021integral component of membrane-IEA-  
GO:0030667secretory granule membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal