Gene: SS18L1

26039
CREST|LP2261
SS18L1, nBAF chromatin remodeling complex subunit
protein-coding
20q13.33
Ensembl:ENSG00000184402 MIM:606472 Vega:OTTHUMG00000032902 UniprotKB:O75177
NG_034255.1
PubMed|SNP Mapped
2   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.132e-2 (AD)  4.695e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6142970chr20:62175801 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6142969chr20:62174127 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH60.958
KPNA10.952
SFXN10.952
PRKCI0.951
CD470.95
NAPG0.948
DNM1L0.947
USP330.947
ARL8B0.947
CDC270.947

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.612
OR4F29-0.559
CSAG1-0.381
MTRNR2L6-0.371
MTRNR2L10-0.367
MTRNR2L9-0.363
KLRB1-0.343
MTRNR2L2-0.325
CXCR2-0.323
MTRNR2L8-0.322

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in increased expression of SS18L1 mRNA"25270620
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SS18L1 mRNA"23829299
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SS18L1 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of SS18L1 mRNA19774075
D001280AtrazineAtrazine results in decreased expression of SS18L1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to SS18L1 promoter]19654925
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SS18L1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of SS18L1 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of SS18L1 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of SS18L1 gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of SS18L1 mRNA15336504
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SS18L1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of SS18L1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of SS18L1 mRNA19549813
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of SS18L1 mRNA23914054
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SS18L1 mRNA28628672
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SS18L1 mRNA29097150
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SS18L1 gene20938992
D017313FenretinideFenretinide results in increased expression of SS18L1 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SS18L1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SS18L1 mRNA28628672
D007854LeadLead affects the splicing of SS18L1 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SS18L1 gene20938992
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SS18L1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SS18L1 mRNA24058054
D014212TretinoinTretinoin results in decreased expression of SS18L1 mRNA20488242
D014635Valproic AcidValproic Acid affects the expression of SS18L1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SS18L1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of SS18L1 mRNA29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003712transcription coregulator activity-IBA21873635  
GO:0003713transcription coactivator activity-IEA-  
GO:0005515protein binding-IPI16189514  21516116  25416956  26871637  
GO ID GO Term Qualifier Evidence PubMed
GO:0006325chromatin organization-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0016358dendrite development-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IBA21873635  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0050775positive regulation of dendrite morphogenesis-IBA21873635  
GO:0050775positive regulation of dendrite morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IDA18331714  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0000780condensed nuclear chromosome, centromeric region-IEA-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005634nucleus-ISS-  
GO:0005829cytosol-IDA-  
GO:0016604nuclear body-IEA-  
GO:0071565nBAF complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28981154Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)Mathies LDAlcohol Clin Exp Res