Gene: ERC2

26059
CAST|CAST1|ELKSL|SPBC110|Spc110
ELKS/RAB6-interacting/CAST family member 2
protein-coding
3p14.3
Ensembl:ENSG00000187672 MIM:617250 Vega:OTTHUMG00000158390 UniprotKB:O15083
NC_000003.12
SNP Mapped
4   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.040e-1 (AD)  1.545e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1352010chr3:56152208 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs17288603chr3:55921186 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7631846chr3:55849368 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6782906chr3:55847492 (GRCh38.p7)C>A / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FAM102B0.964
SYNJ10.954
WDR70.954
PGM2L10.953
NELL20.949
CADPS0.947
PCLO0.946
DCLK10.945
AAK10.944
GPR1580.944

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.582
HEY2-0.563
COPZ2-0.557
CHST14-0.54
RHOD-0.538
RAB13-0.537
YES1-0.531
RNF135-0.526
SYDE1-0.524
MYOM1-0.52

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERC2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERC2 mRNA"27188386
C496492abrineabrine results in decreased expression of ERC2 mRNA22595364
D000082AcetaminophenAcetaminophen results in increased expression of ERC2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ERC2 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ERC2 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ERC2 mRNA21298039
D001151ArsenicArsenic affects the methylation of ERC2 gene25304211
D001151ArsenicArsenic results in increased methylation of ERC2 gene24525453
C006632arsenic trioxidearsenic trioxide results in increased expression of ERC2 mRNA15761015
C015001arsenitearsenite results in increased methylation of ERC2 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ERC2 mRNA21714911
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ERC2 mRNA19770486|2171566
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERC2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of ERC2 mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of ERC2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ERC2 gene28505145
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ERC2 mRNA21266533
D002945CisplatinCisplatin results in decreased expression of ERC2 mRNA25270620
D004026DieldrinDieldrin results in increased expression of ERC2 mRNA20438755
D004041Dietary FatsDietary Fats results in decreased expression of ERC2 mRNA21852083
D000431EthanolEthanol results in decreased expression of ERC2 mRNA19167417
D004397FonofosFonofos results in increased methylation of ERC2 promoter22847954
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERC2 mRNA26752646
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ERC2 mRNA"20188158
D016685MitomycinMitomycin results in decreased expression of ERC2 mRNA25270620
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ERC2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ERC2 mRNA"25620056
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of ERC2 protein19716841
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of ERC2 mRNA]"21673326
D010278ParathionParathion results in increased methylation of ERC2 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of ERC2 mRNA19095052
D010634PhenobarbitalPhenobarbital affects the expression of ERC2 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ERC2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ERC2 mRNA18301758|2081375
D059808PolyphenolsPolyphenols results in decreased expression of ERC2 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in decreased expression of ERC2 mRNA23608068
D011374ProgesteroneProgesterone results in increased expression of ERC2 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of ERC2 mRNA24780913
C059514resveratrolresveratrol results in decreased phosphorylation of ERC2 protein25311616
C012568terbufosterbufos results in increased methylation of ERC2 promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of ERC2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ERC2 mRNA19619570
D013853ThioacetamideThioacetamide results in decreased expression of ERC2 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of ERC2 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ERC2 mRNA20133372
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERC2 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ERC2 mRNA24935251|2627250
D014635Valproic AcidValproic Acid affects the expression of ERC2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ERC2 gene29154799
C025643vinclozolinvinclozolin results in increased expression of ERC2 mRNA23869203
C029297vinylidene chloridevinylidene chloride results in decreased expression of ERC2 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12923177  20195357  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IEA-  
GO:0030054cell junction-IEA-  
GO:0030426growth cone-ISS-  
GO:0042734presynaptic membrane-ISS-  
GO:0048786presynaptic active zone-TAS15217342  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal