Gene: TRPC4AP

26133
C20orf188|PPP1R158|TRRP4AP|TRUSS
transient receptor potential cation channel subfamily C member 4 associated protein
protein-coding
20q11.22
Ensembl:ENSG00000100991 MIM:608430 Vega:OTTHUMG00000032319 UniprotKB:Q8TEL6
NC_000020.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.950e-1 (AD)  9.597e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3736802chr20:35016239 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg16151538chr20:33676388TRPC4AP1.000e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XPO60.954
VCP0.951
PSMD110.949
PI4KB0.949
PIGT0.948
FAF10.947
CCAR20.946
PSMD30.945
GANAB0.944
SSRP10.943

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.764
OR4F29-0.725
MTRNR2L6-0.353
MTRNR2L9-0.349
MTRNR2L10-0.325
KLRB1-0.273
C8orf74-0.256
TTLL10-0.253
MTRNR2L2-0.25
OR4F16-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of TRPC4AP mRNA17562736
D001280AtrazineAtrazine results in increased expression of TRPC4AP mRNA25929836
C006780bisphenol Abisphenol A affects the expression of TRPC4AP mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of TRPC4AP mRNA26982218
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRPC4AP mRNA28628672
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TRPC4AP gene20938992
D003042CocaineCocaine affects the expression of TRPC4AP mRNA20187946
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRPC4AP mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of TRPC4AP mRNA21266533
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRPC4AP mRNA22079256
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRPC4AP mRNA17942748
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TRPC4AP gene20938992
C069837fullerene C60fullerene C60 results in increased expression of TRPC4AP mRNA19167457
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRPC4AP mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRPC4AP mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of TRPC4AP mRNA28628672
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TRPC4AP gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TRPC4AP mRNA"26251327
C028007nickel monoxidenickel monoxide results in increased expression of TRPC4AP mRNA19167457
D019319Okadaic AcidOkadaic Acid results in increased expression of TRPC4AP mRNA25270620
D010269ParaquatParaquat results in decreased expression of TRPC4AP mRNA21371552
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TRPC4AP mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of TRPC4AP mRNA22079256
D018038Sodium SeleniteSodium Selenite results in increased expression of TRPC4AP mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRPC4AP mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TRPC4AP mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TRPC4AP mRNA25613284
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRPC4AP gene25560391
C025643vinclozolinvinclozolin results in decreased expression of TRPC4AP mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-TAS-  
GO:0005515protein binding-IPI19389623  20551172  
GO:0019902phosphatase binding-IDA19389623  
GO ID GO Term Qualifier Evidence PubMed
GO:0006511ubiquitin-dependent protein catabolic process-IDA20551172  
GO:0016567protein ubiquitination-IDA20551172  
GO:0016567protein ubiquitination-IEA-  
GO:0048820hair follicle maturation-IEA-  
GO:0070588calcium ion transmembrane transport-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0031464Cul4A-RING E3 ubiquitin ligase complex-IDA20551172  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal