Gene: KCNG2

26251
KCNF2|KV6.2
potassium voltage-gated channel modifier subfamily G member 2
protein-coding
18q23
Ensembl:ENSG00000178342 MIM:605696 Vega:OTTHUMG00000044541 UniprotKB:Q9UJ96
NC_000018.10
PubMed|SNP Mapped
1   ANCO-SNPs
OD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.300e-1 (AD)  4.056e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs62103177chr18:79864479 (GRCh38.p7)G>Aopioid dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFBR3L0.721
RASL10A0.718
SPATA2L0.704
MMP170.703
PRR70.7
SYT120.689
TMEM1210.681
C1QTNF40.679
SLC39A30.675
IL340.673

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARD3B-0.506
REST-0.495
PARP4-0.488
STK3-0.487
YES1-0.482
PRKD3-0.476
NEDD1-0.469
TGFBR3-0.468
DERA-0.467
PHEX-0.465

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNG2 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of KCNG2 mRNA"27291303
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNG2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNG2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNG2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNG2 mRNA"25510870
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCNG2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNG2 mRNA16483693
D001151ArsenicArsenic affects the methylation of KCNG2 gene25304211
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of KCNG2 mRNA25566086
C006780bisphenol Abisphenol A results in decreased expression of KCNG2 mRNA25181051
D060729Coal AshCoal Ash results in increased expression of KCNG2 mRNA19000753
D003471CuprizoneCuprizone results in decreased expression of KCNG2 mRNA26577399
D016572CyclosporineCyclosporine results in increased methylation of KCNG2 promoter27989131
C004742daidzein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of KCNG2 mRNA16963248
C069837fullerene C60fullerene C60 results in decreased expression of KCNG2 mRNA19167457
C039281furanfuran results in increased expression of KCNG2 mRNA27387713
D019833Genistein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of KCNG2 mRNA16963248
D005839GentamicinsGentamicins results in decreased expression of KCNG2 mRNA22061828
C086566glycitein[Genistein co-treated with daidzein co-treated with glycitein] results in increased expression of KCNG2 mRNA16963248
D007052IbuprofenIbuprofen results in increased expression of KCNG2 mRNA28201806
C028007nickel monoxidenickel monoxide results in decreased expression of KCNG2 mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of KCNG2 mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of KCNG2 mRNA23557933
D014635Valproic AcidValproic Acid results in increased methylation of KCNG2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005249voltage-gated potassium channel activity-IBA21873635  
GO:0005251delayed rectifier potassium channel activity-TAS10551266  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-TAS10551266  
GO:0008016regulation of heart contraction-TAS10551266  
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0050796regulation of insulin secretion-TAS-  
GO:0051260protein homooligomerization-IEA-  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0008076voltage-gated potassium channel complex-IBA21873635  
GO:0008076voltage-gated potassium channel complex-IEA-  
GO:0016021integral component of membrane-IBA21873635  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296072Voltage gated Potassium channelsTAS
R-HSA-1430728MetabolismTAS
R-HSA-163685Integration of energy metabolismTAS
R-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretionTAS
R-HSA-422356Regulation of insulin secretionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24143882Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways. (2014 Jul 1)Gelernter JBiol Psychiatry