Gene: EHF

26298
ESE3|ESE3B|ESEJ
ETS homologous factor
protein-coding
11p13
Ensembl:ENSG00000135373 MIM:605439 Vega:OTTHUMG00000166454 UniprotKB:Q9NZC4
NG_029177.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.274e-1 (AD)  9.529e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7936502chr11:34638260 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPRR2E0.454
TACSTD20.436
IVL0.434
SCEL0.434
SPINK50.432
CRNN0.43
ALDH3B20.412
KRT6A0.412
CEACAM50.408
SERPINB130.401

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPEF2-0.286
OR2H2-0.278
CXorf67-0.266
KLK14-0.264
FGFR4-0.259
CRYBB2-0.252
HS3ST3B1-0.251
CATSPER3-0.25
AGRP-0.244
CELSR1-0.243

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of EHF mRNA"20453058
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of EHF mRNA"15215175
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of EHF mRNA25088246
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of EHF mRNA23630614
C015001arsenitearsenite results in decreased expression of EHF mRNA23974009
C015001arsenitearsenite results in increased methylation of EHF promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of EHF mRNA"17331233
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of EHF mRNA"24160326
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of EHF mRNA26377693
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of EHF mRNA20660070
C006780bisphenol Abisphenol A results in decreased expression of EHF mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of EHF gene28505145
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EHF mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of EHF mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of EHF mRNA20971185
D003703DemecolcineDemecolcine results in increased expression of EHF mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of EHF mRNA27392435
D002945CisplatinCisplatin results in increased expression of EHF mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of EHF mRNA26485663
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of EHF mRNA23649840
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of EHF mRNA]15016801
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EHF mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of EHF mRNA23649840
C039281furanfuran results in decreased methylation of EHF gene22079235
D019833GenisteinGenistein results in decreased expression of EHF mRNA26865667
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of EHF mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of EHF mRNA27169980
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EHF mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of EHF mRNA24231268
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EHF mRNA20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of EHF mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of EHF mRNA20886546
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of EHF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EHF mRNA"25554681
C022838nickel chloridenickel chloride results in increased expression of EHF mRNA24612858
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of EHF mRNA20971185
D017239PaclitaxelPaclitaxel results in decreased expression of EHF mRNA19682730
C006253pirinixic acidpirinixic acid results in increased expression of EHF mRNA17426115|2081375
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of EHF mRNA20660070
D011374ProgesteroneProgesterone results in decreased expression of EHF mRNA22238285
C089730rosiglitazonerosiglitazone results in increased expression of EHF mRNA16982809
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of EHF mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of EHF mRNA25895662
D012906SmokeSmoke results in decreased expression of EHF mRNA21095227
C009277sodium arsenatesodium arsenate results in increased expression of EHF mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of EHF mRNA27257137
D053260SootSoot results in increased expression of EHF mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EHF mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EHF mRNA21570461|2405805
C009495titanium dioxidetitanium dioxide affects the expression of EHF mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of EHF mRNA20133372
D014241TrichloroethyleneTrichloroethylene results in increased methylation of EHF gene27618143
C057693troglitazonetroglitazone results in increased expression of EHF mRNA28973697
D014520UrethaneUrethane results in increased expression of EHF mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of EHF mRNA28001369
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of EHF gene25560391
C551177vemurafenib[(+)-JQ1 compound co-treated with vemurafenib] results in increased expression of EHF mRNA27169980
C029297vinylidene chloridevinylidene chloride results in decreased expression of EHF mRNA26682919
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of EHF mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17027647  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA17027647  
GO:0003677DNA binding-IDA10644770  
GO:0003677DNA binding-TAS10527851  
GO:0003700DNA-binding transcription factor activity-IDA10644770  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0007275multicellular organism development-TAS10644770  
GO:0008283cell proliferation-TAS10644770  
GO:0030154cell differentiation-IBA21873635  
GO:0030855epithelial cell differentiation-IEP10644770  
GO:0045893positive regulation of transcription, DNA-templated-IDA10644770  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA17027647  
GO:0050673epithelial cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IC10644770  
GO:0005654nucleoplasm-IDA-  
GO:0005794Golgi apparatus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal